Search Results - "Marton, M. J."

Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast by Natarajan, Krishnamurthy, Meyer, Michael R., Jackson, Belinda M., Slade, David, Roberts, Christopher, Hinnebusch, Alan G., Marton, Matthew J.

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Experimental annotation of the human genome using microarray technology by Boguski, M. S, Shoemaker, D. D, Schadt, E. E, Armour, C. D, He, Y. D, Garrett-Engele, P, McDonagh, P. D, Loerch, P. M, Leonardson, A, Lum, P. Y, Cavet, G, Wu, L. F, Altschuler, S. J, Edwards, S, King, J, Tsang, J. S, Schimmack, G, Schelter, J. M, Koch, J, Ziman, M, Marton, M. J, Li, B, Cundiff, P, Ward, T, Castle, J, Krolewski, M, Meyer, M. R, Mao, M, Burchard, J, Kidd, M. J, Dai, H, Phillips, J. W, Linsley, P. S, Stoughton, R, Scherer, S

“…The most important product of the sequencing of a genome is a complete, accurate catalogue of genes and their products, primarily messenger RNA transcripts and…”
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Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles by Roberts, Christopher J., Nelson, Bryce, Marton, Matthew J., Stoughton, Roland, Meyer, Michael R., Bennett, Holly A., He, Yudong D., Dai, Hongyue, Walker, Wynn L., Hughes, Timothy R., Tyers, Mike, Boone, Charles, Friend, Stephen H.

“…Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response. Genetic manipulations allowed analysis of changes in…”
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Widespread aneuploidy revealed by DNA microarray expression profiling by Marton, Matthew J, Hughes, Timothy R, Roberts, Christopher J, Dai, Hongyue, Jones, Allan R, Meyer, Michael R, Slade, David, Burchard, Julja, Dow, Sally, Ward, Teresa R, Kidd, Matthew J, Friend, Stephen H

“…Expression profiling using DNA microarrays holds great promise for a variety of research applications, including the systematic characterization of genes…”
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GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2 by MARTON, M. J, CROUCH, D, HINNEBUSCH, A. L

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Gene expression analysis in serial liver fine needle aspirates by Lejnine, S., Marton, M. J., Wang, I.-M., Howell, B. J., Webber, A. L., Maxwell, J. W., Shire, N., Malkov, V., Lunceford, J., Zeremski, M., Sun, A., Ruddy, M., Talal, A. H.

“…Summary No method with low morbidity presently exists for obtaining serial hepatic gene expression measurements in humans. While hepatic fine needle aspiration…”
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Functional Discovery via a Compendium of Expression Profiles by Hughes, Timothy R, Marton, Matthew J, Jones, Allan R, Roberts, Christopher J, Stoughton, Roland, Armour, Christopher D, Bennett, Holly A, Coffey, Ernest, Dai, Hongyue, He, Yudong D, Kidd, Matthew J, King, Amy M, Meyer, Michael R, Slade, David, Lum, Pek Y, Stepaniants, Sergey B, Shoemaker, Daniel D, Gachotte, Daniel, Chakraburtty, Kalpana, Simon, Julian, Bard, Martin, Friend, Stephen H

“…Ascertaining the impact of uncharacterized perturbations on the cell is a fundamental problem in biology. Here, we describe how a single assay can be used to…”
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The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA by Marton, M J, Baim, S B, Ornelles, D A, Shenk, T

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Drug target validation and identification of secondary drug target effects using DNA microarrays by Friend, Stephen H, Marton, Matthew J, DeRisi, Joseph L, Bennett, Holly A, Iyer, Vishwanath R, Meyer, Michael R, Roberts, Christopher J, Stoughton, Roland, Burchard, Julja, Slade, David, Dai, Hongyue, Bassett, Douglas E, Hartwell, Leland H, Brown, Patrick O

“…We describe here a method for drug target validation and identification of secondary drug target effects based on genome-wide gene expression patterns. The…”
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Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins by Harris, K, Lamson, R E, Nelson, B, Hughes, T R, Marton, M J, Roberts, C J, Boone, C, Pryciak, P M

“…Signal transduction pathways with shared components must be insulated from each other to avoid the inappropriate activation of multiple pathways by a single…”
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GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF‐2 alpha kinase GCN2 in amino acid‐starved cells by Vazquez de Aldana, C.R., Marton, M.J., Hinnebusch, A.G.

“…GCN2 is a protein kinase that phosphorylates the alpha‐subunit of translation initiation factor 2 (eIF‐2) and thereby stimulates translation of GCN4 mRNA in…”
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Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer by Linsley, Peter S, Hughes, Timothy R, Mao, Mao, Jones, Allan R, Burchard, Julja, Marton, Matthew J, Shannon, Karen W, Lefkowitz, Steven M, Ziman, Michael, Schelter, Janell M, Meyer, Michael R, Kobayashi, Sumire, Davis, Colleen, Dai, Hongyue, He, Yudong D, Stephaniants, Sergey B, Cavet, Guy, Walker, Wynn L, West, Anne, Coffey, Ernest, Shoemaker, Daniel D, Stoughton, Roland, Blanchard, Alan P, Friend, Stephen H

“…We describe a flexible system for gene expression profiling using arrays of tens of thousands of oligonucleotides synthesized in situ by an ink-jet printing…”
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Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2 by Marton, M J, Vazquez de Aldana, C R, Qiu, H, Chakraburtty, K, Hinnebusch, A G

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Interaction between the Retinoid X Receptor and Transcription Factor IIB Is Ligand-dependent in Vivo by Leong, Gary M., Wang, Ken S., Marton, Matthew J., Blanco, Jorge C.G., Wang, I-Ming, Rolfes, Ronda J., Ozato, Keiko, Segars, James H.

“…The retinoid X receptor (RXR) influences gene activation through heterodimeric and homodimeric association with DNA and associates with TATA binding protein,…”
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Kaonic atoms experiment at the DAΦNE collider by SIDDHARTA/SIDDHARTA-2 by Skurzok, Magdalena, Amirkhani, Abdollah, Baniahmad, A., Bazzi, M., Bosnar, D., Bragadireanu, M., Carminati, M., Cargnelli, M., Clozza, A., Curceanu, Catalina, De Paolis, L., Del Grande, Rafael, Fabbietti, Laura, Fiorini, C., Guaraldo, C., Iliescu, Mariana, Iwasaki, M., Levi Sandri, P., Marton, Johann, Miliucci, Marco, Moskal, Pawel, Niedźwiecki, Szymon, Okada, Susumu, Pietreanu, D., Piscicchia, Kristian, Scordo, Alessandro, Silarski, MIchal, Sirghi, Diana, Sirghi, F., Spallone, Antonio, Tüchler, M., Vazquez Doce, Oton, Widmann, Eberhard, Zmeskal, Johann

“…The excellent quality kaon beam provided by the DA \Phi Φ NE collider of LNF-INFN (Italy) together with SIDDHARTA/SIDDHARTA-2 new experimental techniques, as…”
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A Gene-Expression Signature as a Predictor of Survival in Breast Cancer by van de Vijver, Marc J, He, Yudong D, van 't Veer, Laura J, Dai, Hongyue, Hart, Augustinus A.M, Voskuil, Dorien W, Schreiber, George J, Peterse, Johannes L, Roberts, Chris, Marton, Matthew J, Parrish, Mark, Atsma, Douwe, Witteveen, Anke, Glas, Annuska, Delahaye, Leonie, van der Velde, Tony, Bartelink, Harry, Rodenhuis, Sjoerd, Rutgers, Emiel T, Friend, Stephen H, Bernards, René

“…The patterns of expression of 70 genes in almost 300 breast-cancer specimens revealed two genetic signatures: one correlated with a good prognosis, and the…”
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Gene expression profiling predicts clinical outcome of breast cancer by Friend, Stephen H, van 't Veer, Laura J, Dai, Hongyue, van de Vijver, Marc J, He, Yudong D, Hart, Augustinus A. M, Mao, Mao, Peterse, Hans L, van der Kooy, Karin, Marton, Matthew J, Witteveen, Anke T, Schreiber, George J, Kerkhoven, Ron M, Roberts, Chris, Linsley, Peter S, Bernards, René

“…Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for…”
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Effects of Atmospheric Ozone on Microarray Data Quality by Fare, Thomas L, Coffey, Ernest M, Dai, Hongyue, He, Yudong D, Kessler, Deborah A, Kilian, Kristopher A, Koch, John E, LeProust, Eric, Marton, Matthew J, Meyer, Michael R, Stoughton, Roland B, Tokiwa, George Y, Wang, Yanqun

“…A data anomaly was observed that affected the uniformity and reproducibility of fluorescent signal across DNA microarrays. Results from experimental sets…”
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Evidence that GCN1 and GCN20, Translational Regulators of GCN4, Function on Elongating Ribosomes in Activation of eIF2α Kinase GCN2 by Marton, Matthew J., Vazquez de Aldana, Carlos R., Qiu, Hongfang, Chakraburtty, Kalpana, Hinnebusch, Alan G.

“…In the yeast Saccharomyces cerevisiae, phosphorylation of translation initiation factor eIF2 by protein kinase GCN2 leads to increased translation of the…”
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Identification of genes over-expressed in small cell lung carcinoma using suppression subtractive hybridization and cDNA microarray expression analysis by Bangur, C S, Switzer, A, Fan, L, Marton, MJ, Meyer, M R, Wang, T

“…To identify genes that are differentially over-expressed in Small Cell Lung Carcinoma (SCLC) we have used a combination of suppression subtractive…”
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