Search Results - "Martins Laurindo, Francisco Rafael"

Early and sustained exposure to high-sucrose diet triggers hippocampal ER stress in young rats by Pinto, Bruno Araújo Serra, Melo, Thamys Marinho, Flister, Karla Frida Torres, França, Lucas Martins, Kajihara, Daniela, Tanaka, Leonardo Yuji, Laurindo, Francisco Rafael Martins, Paes, Antonio Marcus de Andrade

“…Early-life environmental insults have been shown to promote long-term development of chronic non-communicable diseases, including metabolic disturbances and…”
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Analysing the impact of modifiable risk factors on cardiovascular disease mortality in Brazil by Gaspar, Renato Simões, Rezende, Leandro F M, Laurindo, Francisco Rafael Martins

“…We have examined the impact of changes in modifiable risk factors on CVD mortality in 26 Brazilian states from 2005 to 2017. Data were acquired from the Global…”
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Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas by De Bessa, Tiphany Coralie, Pagano, Alessandra, Moretti, Ana Iochabel Soares, Oliveira, Percillia Victoria Santos, Mendonça, Samir Andrade, Kovacic, Herve, Laurindo, Francisco Rafael Martins

“…Protein disulfide isomerases including PDIA1 are implicated in cancer progression, but underlying mechanisms are unclear. PDIA1 is known to support vascular…”
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Protein disulfide isomerase plasma levels in healthy humans reveal proteomic signatures involved in contrasting endothelial phenotypes by Oliveira, Percíllia Victória Santos de, Garcia-Rosa, Sheila, Sachetto, Ana Teresa Azevedo, Moretti, Ana Iochabel Soares, Debbas, Victor, De Bessa, Tiphany Coralie, Silva, Nathalia Tenguan, Pereira, Alexandre da Costa, Martins-de-Souza, Daniel, Santoro, Marcelo Larami, Laurindo, Francisco Rafael Martins

“…Redox-related plasma proteins are candidate reporters of protein signatures associated with endothelial structure/function. Thiol-proteins from protein…”
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Hippocampal Endoplasmic Reticulum Stress Hastens Motor and Cognitive Decline in Adult Male Rats Sustainedly Exposed to High-Sucrose Diet by Pinto, Bruno Araújo Serra, Melo, Thamys Marinho, Flister, Karla Frida Torres, França, Lucas Martins, Moreira, Vanessa Ribeiro, Kajihara, Daniela, Mendes, Nelmar Oliveira, Pereira, Silma Regina, Laurindo, Francisco Rafael Martins, Paes, Antonio Marcus Andrade

“…Metabolic dysfunctions, such as hyperglycemia and insulin resistance, have been associated to cognitive impairment and dementia regardless of advanced age,…”
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Internationalization is Necessary, But is it Enough? by Oliveira, Gláucia Maria Moraes de, Lorenzo, Andrea De, Colombo, Fernanda Marciano Consolim, Sternick, Eduardo Back, Brandão, Andréa Araujo, Kaiser, Sergio Emanuel, Quadros, Alexandre Schaan de, Kalil, Renato Abdala Karam, Scaramello, Christianne Brêtas Vieira, Laurindo, Francisco Rafael Martins, Hajjar, Ludhmila Abrahão

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Translational Medicine and Implementation Science: How to Transform What We Know Into What We Do by Luz, Protásio Lemos da, Laurindo, Francisco Rafael Martins

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Impaired vascular smooth muscle cell force-generating capacity and phenotypic deregulation in Marfan Syndrome mice by Nolasco, Patrícia, Fernandes, Carolina Gonçalves, Ribeiro-Silva, João Carlos, Oliveira, Percillia V.S., Sacrini, Mariana, de Brito, Isis Vasconcelos, De Bessa, Tiphany Coralie, Pereira, Lygia V., Tanaka, Leonardo Y., Alencar, Adriano, Laurindo, Francisco Rafael Martins

“…Mechanisms whereby fibrillin-1 mutations determine thoracic aorta aneurysms/dissections (TAAD) in Marfan Syndrome (MFS) are unclear. Most aortic aneurysms…”
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Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice by Flister, Karla Frida Torres, Pinto, Bruno Araújo Serra, França, Lucas Martins, Coêlho, Caio Fernando Ferreira, dos Santos, Pâmela Costa, Vale, Caroline Castro, Kajihara, Daniela, Debbas, Victor, Laurindo, Francisco Rafael Martins, Paes, Antonio Marcus de Andrade

“…Childhood consumption of added sugars, such as sucrose, has been associated to increased risk of metabolic syndrome (MetS) and nonalcoholic fatty liver disease…”
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Isoflavone and the heme oxygenase system in ischemic acute kidney injury in rats by Watanabe, Mirian, de Moura Neiva, Luciana Barros, da Costa Santos, Célio Xavier, Rafael Martins Laurindo, Francisco, de Fátima Fernandes Vattimo, Maria

“…Ischemic acute kidney injury (AKI) is mediated by reactive oxygen species and inflammatory infiltration, among others. The present study was performed to…”
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Endothelial Nox2 Limits Systemic Inflammation and Hypotension in Endotoxemia by Controlling Expression of Toll-Like Receptor 4 by Trevelin, Silvia Cellone, Sag, Can Martin, Zhang, Min, Alves-Filho, José Carlos, Cunha, Thiago Mattar, Santos, Célio Xavier dos, Sawyer, Greta, Murray, Thomas, Brewer, Alison, Laurindo, Francisco Rafael Martins, Protti, Andrea, Lopes, Lucia Rossetti, Ivetic, Aleksandar, Cunha, Fernando Queiroz, Shah, Ajay M.

“…Leukocyte Nox2 is recognized to have a fundamental microbicidal function in sepsis but the specific role of Nox2 in endothelial cells (EC) remains poorly…”
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Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy by Nunes, João Paulo Silva, Andrieux, Pauline, Brochet, Pauline, Almeida, Rafael Ribeiro, Kitano, Eduardo, Honda, André Kenji, Iwai, Leo Kei, Andrade-Silva, Débora, Goudenège, David, Alcântara Silva, Karla Deysiree, Vieira, Raquel de Souza, Levy, Débora, Bydlowski, Sergio Paulo, Gallardo, Frédéric, Torres, Magali, Bocchi, Edimar Alcides, Mano, Miguel, Santos, Ronaldo Honorato Barros, Bacal, Fernando, Pomerantzeff, Pablo, Laurindo, Francisco Rafael Martins, Teixeira, Priscila Camillo, Nakaya, Helder I, Kalil, Jorge, Procaccio, Vincent, Chevillard, Christophe, Cunha-Neto, Edecio

“…Infection by the protozoan causes Chagas disease cardiomyopathy (CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million…”
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Urate hydroperoxide oxidizes endothelial cell surface protein disulfide isomerase-A1 and impairs adherence by Mineiro, Marcela Franco, Patricio, Eliziane de Souza, Peixoto, Álbert Souza, Araujo, Thaís Larissa Silva, da Silva, Railmara Pereira, Moretti, Ana Iochabel Soares, Lima, Filipe Silva, Laurindo, Francisco Rafael Martins, Meotti, Flavia Carla

“…Extracellular surface protein disulfide isomerase-A1 (PDI) is involved in platelet aggregation, thrombus formation and vascular remodeling. PDI performs redox…”
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Tartrate-resistant acid phosphatase activity and glutathione levels are modulated during hFOB 1.19 osteoblastic differentiation by de Souza Malaspina, Tatiana Salles, dos Santos, Célio Xavier, Campanelli, Ana Paula, Laurindo, Francisco Rafael Martins, Sogayar, Mari Cleide, Granjeiro, José Mauro

“…Tartrate-resistant acid phosphatase (TRAP) is a well-known marker of osteoclasts and bone resorption. Here we have investigated whether osteoblast-like cells…”
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Chemotherapy acutely impairs neurovascular and hemodynamic responses in women with breast cancer by Sales, Allan Robson Kluser, Negrão, Marcelo Vailati, Testa, Laura, Ferreira-Santos, Larissa, Groehs, Raphaela Villar Ramalho, Carvalho, Bruna, Toschi-Dias, Edgar, Rocha, Natalia Galito, Laurindo, Francisco Rafael Martins, Debbas, Victor, Rondon, Maria Urbana P B, Mano, Max Sena, Hajjar, Ludhmila Abrahao, Hoff, Paulo Marcelo Gehm, Filho, Roberto Kalil, Negrão, Carlos Eduardo

“…The purpose of the present study was to test the hypothesis that doxorubicin (DX) and cyclophosphamide (CY) adjuvant chemotherapy (CHT) acutely impairs…”
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Hepatic gene expression profile associated with non-alcoholic steatohepatitis protection by S-nitroso- N-acetylcysteine in ob/ob mice by Souza de Oliveira, Claudia Pinto Marques, Stefano, José Tadeu, de Lima, Vicência Mara Rodrigues, de Sá, Sandra Valéria, Simplicio, Fernanda Ibanez, de Mello, Evandro Sobrosa, Corrêa-Giannella, Maria Lúcia, Ferreira Alves, Venâncio Avancini, Martins Laurindo, Francisco Rafael, de Oliveira, Marcelo Ganzarolli, Giannella-Neto, Daniel, Carrilho, Flair José

“…To understand the molecular mechanisms underlying non-alcoholic steatohepatitis (NASH) prevention by S-nitroso- N-acetylcysteine (SNAC), an NO donor that…”
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Unfolded Protein Response: Cause or Consequence of Lipid and Lipoprotein Metabolism Disturbances? by Pinto, Bruno Araújo Serra, França, Lucas Martins, Laurindo, Francisco Rafael Martins, Paes, Antonio Marcus de Andrade

“…The liver plays a capital role in the control of whole body energy homeostasis through the metabolization of dietary carbohydrates and lipids. However, under…”
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Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state by Trevelin, Silvia Cellone, dos Santos, Célio Xavier, Ferreira, Raphael Gomes, de Sá Lima, Larissa, Silva, Rangel Leal, Scavone, Cristoforo, Curi, Rui, Alves-Filho, José Carlos, Cunha, Thiago Mattar, Roxo-Júnior, Pérsio, Cervi, Maria-Célia, Laurindo, Francisco Rafael Martins, Hothersall, John Stephen, Cobb, Andrew M., Zhang, Min, Ivetic, Aleksandar, Shah, Ajay M., Lopes, Lucia Rossetti, Cunha, Fernando Queiroz

“…The reactive-oxygen-species-(ROS)-generating-enzyme Nox2 is essential for leukocyte anti-microbial activity. However its role in cellular redox homeostasis…”
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Exercise improves endothelial function: A local analysis of production of nitric oxide and reactive oxygen species by Tanaka, Leonardo Yuji, Bechara, Luiz Roberto Grassmann, dos Santos, Adriana Marques, Jordão, Camila Paixão, de Sousa, Luís Gustavo Oliveira, Bartholomeu, Teresa, Ventura, Laura Inês, Laurindo, Francisco Rafael Martins, Ramires, Paulo Rizzo

“…This study aimed at investigating the acute effects of aerobic exercise on endothelium-dependent vasomotor function of rat aorta, as well as mechanisms…”
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Mechanisms underlying hypertriglyceridemia in rats with monosodium l-glutamate-induced obesity: Evidence of XBP-1/PDI/MTP axis activation by França, Lucas Martins, Freitas, Larissa Nara Costa, Chagas, Vinicyus Teles, Coêlho, Caio Fernando Ferreira, Barroso, Wermerson Assunção, Costa, Graciomar Conceição, Silva, Lucilene Amorim, Debbas, Victor, Laurindo, Francisco Rafael Martins, Paes, Antonio Marcus de Andrade

“…•MSG-obese rats exhibit metabolic and morphologic features of metabolic syndrome.•VLDL synthesis and secretion is twofold in MSG-obese rats.•ER stress sensors…”
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