Search Results - "Martins, Ralph"

The role of type 2 diabetes in neurodegeneration by Verdile, Giuseppe, Fuller, Stephanie J, Martins, Ralph N

“…Abstract A growing body of evidence links type-2 diabetes (T2D) with dementia and neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most…”
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Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease by Chatterjee, Pratishtha, Pedrini, Steve, Stoops, Erik, Goozee, Kathryn, Villemagne, Victor L., Asih, Prita R., Verberk, Inge M. W., Dave, Preeti, Taddei, Kevin, Sohrabi, Hamid R., Zetterberg, Henrik, Blennow, Kaj, Teunissen, Charlotte E., Vanderstichele, Hugo M., Martins, Ralph N.

“…Glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, can be measured in blood samples, and has been associated with Alzheimer’s disease…”
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Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer’s disease pathogenesis by Dhiman, Kunal, Blennow, Kaj, Zetterberg, Henrik, Martins, Ralph N., Gupta, Veer Bala

“…Alzheimer’s disease (AD) is a multifactorial age-related brain disease. Numerous pathological events run forth in the brain leading to AD. There is an initial…”
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Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study by Burnham, Samantha C, PhD, Bourgeat, Pierrick, PhD, Doré, Vincent, PhD, Savage, Greg, Prof, Brown, Belinda, PhD, Laws, Simon, PhD, Maruff, Paul, Prof, Salvado, Olivier, PhD, Ames, David, Prof, Martins, Ralph N, Prof, Masters, Colin L, Prof, Rowe, Christopher C, Prof, Villemagne, Victor L, Dr

“…Summary Background Brain amyloid β (Aβ) deposition and neurodegeneration have been documented in about 50–60% of cognitively healthy elderly individuals (aged…”
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High‐density lipoprotein‐related cholesterol metabolism in Alzheimer’s disease by Pedrini, Steve, Chatterjee, Pratishtha, Hone, Eugene, Martins, Ralph N.

“…High‐density lipoproteins (HDL) are a heterogeneous class of molecules whose main function is to remove excess cholesterol through a mechanism called reverse…”
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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease by Newsholme, Philip, Fraser, Paul E., Wijesekara, Nadeeja, Rowles, Joanne, Sabale, Miheer, Medic, Sandra, Cruzat, Vinicius F., Keane, Kevin N., Verdile, Giuseppe, Martins, Ralph N.

“…Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent…”
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Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques by Li, Yan, Schindler, Suzanne E., Bollinger, James G., Ovod, Vitaliy, Mawuenyega, Kwasi G., Weiner, Michael W., Shaw, Leslie M., Masters, Colin L., Fowler, Christopher J., Trojanowski, John Q., Korecka, Magdalena, Martins, Ralph N., Janelidze, Shorena, Hansson, Oskar, Bateman, Randall J.

“…To determine the diagnostic accuracy of a plasma Aβ42/Aβ40 assay in classifying amyloid PET status across global research studies using samples collected by…”
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Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease by Chatterjee, Pratishtha, Pedrini, Steve, Ashton, Nicholas J., Tegg, Michelle, Goozee, Kathryn, Singh, Abhay K., Karikari, Thomas K., Simrén, Joel, Vanmechelen, Eugeen, Armstrong, Nicola J., Hone, Eugene, Asih, Prita R., Taddei, Kevin, Doré, Vincent, Villemagne, Victor L., Sohrabi, Hamid R., Zetterberg, Henrik, Masters, Colin L., Blennow, Kaj, Martins, Ralph N.

“…Introduction This study involved a parallel comparison of the diagnostic and longitudinal monitoring potential of plasma glial fibrillary acidic protein…”
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PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer's Disease Brain by Bharadwaj, Prashant, Martins, Ralph N

“…Increased amyloid-β (Aβ) accumulation associated with abnormal autophagy-lysosomal activity and nutrient kinase dysregulation are common features in…”
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Plasma high‐density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume by Pedrini, Steve, Doecke, James D., Hone, Eugene, Wang, Penghao, Thota, Rohith, Bush, Ashley I., Rowe, Christopher C., Dore, Vincent, Villemagne, Victor L., Ames, David, Rainey‐Smith, Stephanie, Verdile, Giuseppe, Sohrabi, Hamid R., Raida, Manfred R., Taddei, Kevin, Gandy, Sam, Masters, Colin L., Chatterjee, Pratishtha, Martins, Ralph N.

“…Cholesterol levels have been repeatedly linked to Alzheimer's Disease (AD), suggesting that high levels could be detrimental, but this effect is likely…”
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Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults by Rainey-Smith, Stephanie R., Brown, Belinda M., Sohrabi, Hamid R., Shah, Tejal, Goozee, Kathryn G., Gupta, Veer B., Martins, Ralph N.

“…Curcumin therapy in animals has produced positive cognitive and behavioural outcomes; results of human trials, however, have been inconsistent. In this study,…”
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Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline by Shah, Tejal M., Weinborn, Michael, Verdile, Giuseppe, Sohrabi, Hamid R., Martins, Ralph N.

“…Successfully assisting older adults to maintain or improve cognitive function, particularly when they are dealing with neurodegenerative disorders such as…”
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Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease by Huynh, Kevin, Lim, Wei Ling Florence, Giles, Corey, Jayawardana, Kaushala S., Salim, Agus, Mellett, Natalie A., Smith, Adam Alexander T., Olshansky, Gavriel, Drew, Brian G., Chatterjee, Pratishtha, Martins, Ian, Laws, Simon M., Bush, Ashley I., Rowe, Christopher C., Villemagne, Victor L., Ames, David, Masters, Colin L., Arnold, Matthias, Nho, Kwangsik, Saykin, Andrew J., Baillie, Rebecca, Han, Xianlin, Kaddurah-Daouk, Rima, Martins, Ralph N., Meikle, Peter J.

“…Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many…”
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Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease by Chatterjee, Pratishtha, Fernando, Malika, Fernando, Binosha, Dias, Cintia B., Shah, Tejal, Silva, Renuka, Williams, Shehan, Pedrini, Steve, Hillebrandt, Heidi, Goozee, Kathryn, Barin, Edward, Sohrabi, Hamid R., Garg, Manohar, Cunnane, Stephen, Martins, Ralph N.

“…•Brain glucose hypometabolism is a major early hallmark of AD.•CO is a rich source of MCT, and ketone bodies arise from MCT metabolism.•Ketone bodies serve as…”
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Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study by Villemagne, Victor L, Dr, Burnham, Samantha, PhD, Bourgeat, Pierrick, PhD, Brown, Belinda, PhD, Ellis, Kathryn A, PhD, Salvado, Olivier, PhD, Szoeke, Cassandra, MBBS, Macaulay, S Lance, PhD, Martins, Ralph, Prof, Maruff, Paul, PhD, Ames, David, Prof, Rowe, Christopher C, Prof, Masters, Colin L, Prof

“…Summary Background Similar to most chronic diseases, Alzheimer's disease (AD) develops slowly from a preclinical phase into a fully expressed clinical…”
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Autophagy Modulation as a Treatment of Amyloid Diseases by Mputhia, Zoe, Hone, Eugene, Tripathi, Timir, Sargeant, Tim, Martins, Ralph, Bharadwaj, Prashant

“…Amyloids are fibrous proteins aggregated into toxic forms that are implicated in several chronic disorders. More than 30 diseases show deposition of fibrous…”
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Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review by Jayakody, Dona M P, Friedland, Peter L, Martins, Ralph N, Sohrabi, Hamid R

“…Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world's population. The peripheral and…”
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Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes by Miklossy, Judith, Qing, Hong, Radenovic, Aleksandra, Kis, Andras, Vileno, Bertrand, Làszló, Forró, Miller, Lisa, Martins, Ralph N, Waeber, Gerard, Mooser, Vincent, Bosman, Fred, Khalili, Kamel, Darbinian, Nune, McGeer, Patrick L

“…Abstract Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (Aβ) and…”
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Plasma Aβ42/40 ratio, p‐tau181, GFAP, and NfL across the Alzheimer's disease continuum: A cross‐sectional and longitudinal study in the AIBL cohort by Chatterjee, Pratishtha, Pedrini, Steve, Doecke, James D., Thota, Rohith, Villemagne, Victor L., Doré, Vincent, Singh, Abhay K., Wang, Penghao, Rainey‐Smith, Stephanie, Fowler, Christopher, Taddei, Kevin, Sohrabi, Hamid R., Molloy, Mark P., Ames, David, Maruff, Paul, Rowe, Christopher C., Masters, Colin L., Martins, Ralph N.

“…Introduction Plasma amyloid beta (Aβ)1‐42/Aβ1‐40 ratio, phosphorylated‐tau181 (p‐tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL)…”
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Development and validation of the Montreal cognitive assessment for people with hearing impairment (MoCA-H) by Dawes, Piers, Reeves, David, Yeung, Wai Kent, Holland, Fiona, Charalambous, Anna Pavlina, Côté, Mathieu, David, Renaud, Helmer, Catherine, Laforce, Robert, Martins, Ralph N, Politis, Antonis, Pye, Annie, Russell, Gregor, Sheikh, Saima, Sirois, Marie-Josée, Sohrabi, Hamid R, Thodi, Chyrssoula, Gallant, Kathleen, Nasreddine, Ziad, Leroi, Iracema

“…Hearing impairment is common among older adults and affects cognitive assessments for identification of dementia which rely on good hearing function. We…”
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