Search Results - "Martins, R.N"

A novel study on association between untreated hearing loss and cognitive functions of older adults: Baseline non‐verbal cognitive assessment results by Jayakody, D.M.P., Friedland, P.L., Eikelboom, R.H., Martins, R.N., Sohrabi, H.R.

“…Background Age‐related hearing loss (ARHL) is highly prevalent in older adults, and more than two‐thirds above age of 70 years suffer from ARHL. Recent studies…”
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The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2, ε3 and ε4 knock-in mice by Jenner, A.M, Lim, W.L.F, Ng, M.P.E, Wenk, M.R, Shui, G, Sharman, M.J, Gandy, S.E, Martins, R.N

“…Abstract Despite apolipoprotein E's important role in cholesterol transport and metabolism in the brain as well as its influence on Alzheimer's disease, the…”
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Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity by Taddei, K, Laws, S.M, Verdile, G, Munns, S, D’Costa, K, Harvey, A.R, Martins, I.J, Hill, F, Levy, E, Shaw, J.E, Martins, R.N

“…Abstract Amyloid-β (Aβ) peptides play a central role in the pathogenesis of Alzheimer's disease. There is accumulating evidence that supports the notion that…”
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Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor by Ling, Xie, Martins, R N, Racchi, M, Craft, S, Helmerhorst, E

“…Amyloid beta (Abeta) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Abeta peptides can inhibit the effect…”
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Baseline data from the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing by Ellis, K.A, Rowe, C, Masters, C.L, Martins, R.N, Hudson, P, Milner, A, Bevege, L, Ames, D

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IN54-TH-01 Biomarkers for Alzheimer's disease from large cohort studies by Milner, A, Ellis, K.A, Bush, A.I, Masters, C.L, De Fazio, D, Foster, J, Hudson, P, Lautenschlager, N.T, Lenzo, N, Martins, R.N, Pike, K, Rowe, C.C, Savage, G, Szoeke, C, Taddei, K, Villemagne, V.L, Woodward, M, Darby, D, Ames, D

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Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment by Cheng, L, Doecke, J D, Sharples, R A, Villemagne, V L, Fowler, C J, Rembach, A, Martins, R N, Rowe, C C, Macaulay, S L, Masters, C L, Hill, A F

“…There is no consensus for a blood-based test for the early diagnosis of Alzheimer’s disease (AD). Expression profiling of small non-coding RNA’s, microRNA…”
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Quantitative MR Imaging R2 Relaxometry in Elderly Participants Reporting Memory Loss by House, M.J, St. Pierre, T.G, Foster, J.K, Martins, R.N, Clarnette, R

“…In Alzheimer disease (AD), elevated brain iron concentrations in gray matter suggest a disruption in iron homeostasis, while demyelination processes in white…”
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Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels by Masters, C.L., Multhaup, G., Simms, G., Pottgiesser, J., Martins, R.N., Beyreuther, K.

“…The protein component of Alzheimer's disease amyloid [neurofibrillary tangles (NFT), amyloid plaque core and congophilic angiopathy] is an aggregated…”
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The amyloid precursor protein of Alzheimer's disease is released by human platelets by BUSH, A. I, MARTINS, R. N, BEYREUTHER, K, MASTERS, C. L, MOIR, R, FULLER, S, MIWARD, E, CURRIE, J, AMES, D, WEIDEMANN, A, FISCHER, P, MULTHAUP, G

“…Western blots of normal human platelets, employing a monoclonal antibody raised against the full-length amyloid precursor protein of Alzheimer's disease…”
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Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer’s disease? by Brown, B M, Peiffer, J J, Martins, R N

“…Western countries are experiencing aging populations and increased longevity; thus, the incidence of dementia and Alzheimer’s disease (AD) in these countries…”
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An anemia of Alzheimer's disease by Faux, N G, Rembach, A, Wiley, J, Ellis, K A, Ames, D, Fowler, C J, Martins, R N, Pertile, K K, Rumble, R L, Trounson, B, Masters, C L, Bush, A I

“…Lower hemoglobin is associated with cognitive impairment and Alzheimer's disease (AD). Since brain iron homeostasis is perturbed in AD, we investigated whether…”
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The descriptive and molecular epidemiology of HHV-8 among population groups of the Amazon region of Brazil by Ishak, R., Martins, R.N., Machado, L.F.A., Vallinoto, A.C.R., Lobato, L., Sata, T., Ishak, M.O.G.

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APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease by Lim, Y Y, Villemagne, V L, Laws, S M, Pietrzak, R H, Snyder, P J, Ames, D, Ellis, K A, Harrington, K, Rembach, A, Martins, R N, Rowe, C C, Masters, C L, Maruff, P

“…Accumulation of β-amyloid (Aβ) in the brain is associated with memory decline in healthy individuals as a prelude to Alzheimer’s disease (AD). Genetic factors…”
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Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition by CHETELAT, G, VILLEMAGNE, V. L, VILLAIN, N, JONES, G, ELLIS, K. A, AMES, D, MARTINS, R. N, MASTERS, C. L, ROWE, C. C

“…Given the recent and growing interest in the concepts of prodromal and presymptomatic Alzheimer disease, it is crucial to determine whether the presence of…”
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Dietary patterns and cognitive decline in an Australian study of ageing by Gardener, S L, Rainey-Smith, S R, Barnes, M B, Sohrabi, H R, Weinborn, M, Lim, Y Y, Harrington, K, Taddei, K, Gu, Y, Rembach, A, Szoeke, C, Ellis, K A, Masters, C L, Macaulay, S L, Rowe, C C, Ames, D, Keogh, J B, Scarmeas, N, Martins, R N

“…The aim of this paper was to investigate the association of three well-recognised dietary patterns with cognitive change over a 3-year period. Five hundred and…”
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Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing by Brown, B M, Peiffer, J J, Taddei, K, Lui, J K, Laws, S M, Gupta, V B, Taddei, T, Ward, V K, Rodrigues, M A, Burnham, S, Rainey-Smith, S R, Villemagne, V L, Bush, A, Ellis, K A, Masters, C L, Ames, D, Macaulay, S L, Szoeke, C, Rowe, C C, Martins, R N

“…Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to…”
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Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer’s disease by Verdile, G, Laws, S M, Henley, D, Ames, D, Bush, A I, Ellis, K A, Faux, N G, Gupta, V B, Li, Q-X, Masters, C L, Pike, K E, Rowe, C C, Szoeke, C, Taddei, K, Villemagne, V L, Martins, R N

“…Testosterone and gonadotropins have been associated with cognitive decline in men and the modulation of β amyloid (Aβ) metabolism. The relatively few studies…”
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Mannose-binding lectin 2 (Mbl2) gene polymorphisms are related to protein plasma levels, but not to heart disease and infection by Chlamydia by Queiroz, M A F, Gomes, S T M, Almeida, N C C, Souza, M I M, Costa, S R C F, Hermes, R B, Lima, S S, Zaninotto, M M, Fossa, M A A, Maneschy, M A, Martins-Feitosa, R N, Azevedo, V N, Machado, L F A, Ishak, M O G, Ishak, R, Vallinoto, A C R

“…The presence of the single nucleotide polymorphisms in exon 1 of the mannose-binding lectin 2 (MBL2) gene was evaluated in a sample of 159 patients undergoing…”
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A blood-based predictor for neocortical Aβ burden in Alzheimer’s disease: results from the AIBL study by Burnham, S C, Faux, N G, Wilson, W, Laws, S M, Ames, D, Bedo, J, Bush, A I, Doecke, J D, Ellis, K A, Head, R, Jones, G, Kiiveri, H, Martins, R N, Rembach, A, Rowe, C C, Salvado, O, Macaulay, S L, Masters, C L, Villemagne, V L

“…Dementia is a global epidemic with Alzheimer’s disease (AD) being the leading cause. Early identification of patients at risk of developing AD is now becoming…”
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