Search Results - "Martins, Manoela D"
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Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma
Published in Journal of cell science (01-01-2019)“…Tumors are composed of heterogeneous phenotypes, each having different sensitivities to the microenvironment. One microenvironment characteristic - matrix…”
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Prognostic value of CRTC1‐MAML2 translocation in salivary mucoepidermoid carcinoma: Systematic review and meta‐analysis
Published in Journal of oral pathology & medicine (01-05-2020)“…The presence of the CRTC1‐MAML2 translocation has been described in mucoepidermoid carcinoma (MEC) as a predictor of better survival rates. However, the real…”
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Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence
Published in Stem cell research (01-05-2017)“…Adenoid cystic carcinoma (ACC) is an uncommon malignancy of the salivary glands that is characterized by local recurrence and distant metastasis due to its…”
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Teledentistry: A Tool to Promote Continuing Education Actions on Oral Medicine for Primary Healthcare Professionals
Published in Telemedicine journal and e-health (01-04-2017)“…Difficulties in diagnosis of oral mucosal lesions are a significant cause of delayed oral cancer diagnosis, and this difficulty may be due to gaps in…”
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Immunohistochemical Study of TGF-β1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma: Correlations Between Clinicopathologic Factors and Overall Survival
Published in Applied immunohistochemistry & molecular morphology (01-10-2017)“…The aim of the present study was to analyze transforming growth factor β1 (TGF-β1) expression in cases of leukoplakia and oral squamous cell carcinoma (OSCC)…”
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TrkB-Targeted Therapy for Mucoepidermoid Carcinoma
Published in Biomedicines (24-11-2020)“…The brain-derived neurotrophic factor (BDNF)/tyrosine receptor kinase B (TrkB) pathway was previously associated with key oncogenic outcomes in a number of…”
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Cell contractility drives mechanical memory of oral squamous cell carcinoma
Published in Molecular biology of the cell (01-08-2023)“…Matrix stiffening is ubiquitous in solid tumors and can direct epithelial-mesenchymal transition (EMT) and cancer cell migration. Stiffened niche can even…”
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Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence
Published in Cancer letters (01-10-2019)“…Head and neck cancer (HNSCC) are one of the most common solid malignancies of the world, being responsible for over 350,000 deaths every year. Much of the…”
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Oral desmoplastic melanoma mimicking inflammatory hyperplasia
Published in Gerodontology (01-06-2012)“…doi: 10.1111/j.1741‐2358.2011.00482.x Oral desmoplastic melanoma mimicking inflammatory hyperplasia Introduction: Desmoplastic melanoma (DM) arising in the…”
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Hypoacetylation of acetyl‐histone H3 (H3K9ac) as marker of poor prognosis in oral cancer
Published in Histopathology (01-08-2017)“…Aims Epigenetics refers to changes in cell characteristics that occur independently of modifications to the DNA sequence. Oral carcinogenesis is influenced by…”
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Titanium Activates the DNA Damage Response Pathway in Oral Epithelial Cells: A Pilot Study
Published in The International journal of oral and maxillofacial implants (01-11-2017)“…To evaluate the effect of titanium (Ti) particles on oral epithelial cell homeostasis and the potential of dental implants to release Ti debris upon insertion…”
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Propolis: A useful agent on psychiatric and neurological disorders? A focus on CAPE and pinocembrin components
Published in Medicinal research reviews (01-03-2021)“…Propolis consists of a honeybee product, with a complex mix of substances that have been widely used in traditional medicine. Among several compounds present…”
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Patient-derived xenograft (PDX) tumors increase growth rate with time
Published in Oncotarget (16-02-2016)“…Patient-derived xenograft (PDX) models are frequently used for translational cancer research, and are assumed to behave consistently as the tumor ages…”
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Social networking website increases efficacy and engagement in a distance learning course about oral lesions
Published in Journal of dental education (01-02-2024)“…Distance learning appears to be an attractive approach to continuing education courses, but one barrier is maintaining learner engagement throughout the…”
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Head and neck cancer patient-derived xenograft models – A systematic review
Published in Critical reviews in oncology/hematology (01-11-2020)“…[Display omitted] •This is the first systematic review that summarizes the use of HNC-PDX.•In general, the studies were flawed in terms of detailing the…”
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Continuing education activities improve dentists’ self‐efficacy to manage oral mucosal lesions and oral cancer
Published in European journal of dental education (01-02-2021)“…Objectives This cross‐sectional study aims to evaluate whether Continuing Education Activities (CEA) influence dentists’ behaviour in relation to oral lesions…”
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Photobiomodulation therapy drives massive epigenetic histone modifications, stem cells mobilization and accelerated epithelial healing
Published in Journal of biophotonics (01-02-2021)“…Emerging evidence indicates the clinical benefits of photobiomodulation therapy (PBMT) in the management of skin and mucosal wounds. Here, we decided to…”
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Targeting histone deacetylase and NFκB signaling as a novel therapy for Mucoepidermoid Carcinomas
Published in Scientific reports (01-02-2018)“…Malignancies from the salivary glands are rare and represent 11% of all cancers from the oropharyngeal anatomical area. Mucoepidermoid Carcinomas (MEC) is the…”
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Expression of matrix metalloproteinases 2 and 9 in odontogenic myxoma in vivo and in vitro
Published in Journal of Oral Science (2008)“…Odontogenic myxoma is a benign neoplasm, which presents local invasiveness and tendency for recurrence. Matrix metalloproteinases (MMPs) 2 and 9 are involved…”
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