Search Results - "Martins, Cláudia"

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications by Martins, Cláudia, Sousa, Flávia, Araújo, Francisca, Sarmento, Bruno

“…Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research…”
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Multi-ligand functionalized blood-to-tumor sequential targeting strategies in the field of glioblastoma nanomedicine by Martins, Cláudia, Sarmento, Bruno

“…Glioblastoma (GBM) is an unmet clinical need characterized by a standard of care (SOC) 5-year survival rate of only 5%, and a treatment mostly palliative…”
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Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology by Moura, Rui Pedro, Martins, Cláudia, Pinto, Soraia, Sousa, Flávia, Sarmento, Bruno

“…The blood-brain barrier (BBB) is a highly limiting barrier that prevents the brain from contacting with several circulating molecules, including harmful…”
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Bioinspired Hydrogel Electrospun Fibers for Spinal Cord Regeneration by Chen, Chunmao, Tang, Jincheng, Gu, Yong, Liu, Lili, Liu, Xingzhi, Deng, Lianfu, Martins, Cláudia, Sarmento, Bruno, Cui, Wenguo, Chen, Liang

“…Fully simulating the components and microstructures of soft tissue is a challenge for its functional regeneration. A new aligned hydrogel microfiber scaffold…”
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Experimental and Clinical Treatment of Chagas Disease: A Review by Sales Junior, Policarpo Ademar, Molina, Israel, Fonseca Murta, Silvane Maria, Sánchez-Montalvá, Adrián, Salvador, Fernando, Corrêa-Oliveira, Rodrigo, Carneiro, Cláudia Martins

“…Chagas disease (CD) is caused by the protozoan parasite that infects a broad range of triatomines and mammalian species, including man. It afflicts 8 million…”
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Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma? by Macedo-Pereira, Ana, Martins, Cláudia, Lima, Jorge, Sarmento, Bruno

“…Glioblastoma (GBM) is an adult's most aggressive brain tumor. The advances in molecular pathology and cell signaling pathways have deepened researchers'…”
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Nanomedicine approaches for treating glioblastoma by Martins, Cláudia, Pacheco, Catarina, Faria, Paulo, Sarmento, Bruno

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Chemical modification of drug molecules as strategy to reduce interactions with mucus by Araújo, Francisca, Martins, Cláudia, Azevedo, Cláudia, Sarmento, Bruno

“…Many drug molecules possess inadequate physical-chemical characteristics that prevent to surpass the viscous mucus layer present in the surface of mucosal…”
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PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor by Fernandes, Carlos, Martins, Cláudia, Fonseca, André, Nunes, Rute, Matos, Maria João, Silva, Renata, Garrido, Jorge, Sarmento, Bruno, Remião, Fernando, Otero-Espinar, Francisco J, Uriarte, Eugenio, Borges, Fernanda

“…Despite research efforts to discover new drugs for Parkinson treatment, the majority of candidates fail in preclinical and clinical trials due to inadequate…”
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Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments by Castro, Flávia, Martins, Cláudia, Silveira, Maria José, Moura, Rui Pedro, Pereira, Catarina Leite, Sarmento, Bruno

“…Although nanocarriers offer many advantages as drug delivery systems, their poor stability in circulation, premature drug release and nonspecific uptake in…”
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Was Culture a Commodity ‘all’ Victorians Could Afford? – Notes on the First British Public Museums by Martins, Cláudia

“…The etymology of 'mouseion' gave rise to the word ‘museum’ and initially referred to the temple of the Muses. It is noteworthy to recall that the first museum…”
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Clofazimine functionalized polymeric nanoparticles for brain delivery in the tuberculosis treatment by de Castro, Renata Ribeiro, do Carmo, Flavia Almada, Martins, Cláudia, Simon, Alice, de Sousa, Valeria Pereira, Rodrigues, Carlos Rangel, Cabral, Lucio Mendes, Sarmento, Bruno

“…[Display omitted] •Clofazimine-loaded PLGA-PEG nanoparticles (NP-CFZ) were produced by nanoprecipitation.•NP-CFZ were functionalized with a peptide…”
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Metabolomics to Study Human Aging: A Review by Martins, Claudia, Magalhães, Sandra, Almeida, Idália, Neto, Vanessa, Rebelo, Sandra, Nunes, Alexandra

“…In the last years, with the increase in the average life expectancy, the world's population is progressively aging, which entails social, health and economic…”
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Competitive Adsorption of Phenolic Acids, Secoiridoids, and Flavonoids in Quercetin Molecularly Imprinted Polymers and Application for Fractionation of Olive Leaf Extracts by Almeida, Ayssata, Martins, Cláudia, Dias, Rolando C. S., Costa, Mário Rui P. F. N.

“…The competitive adsorption of phenolic acids, secoiridoids, and flavonoids in a molecularly imprinted polymer (MIP) functionalized with 4-vinylpiridine (4VP)…”
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Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy by Martins, Cláudia, Araújo, Francisca, Gomes, Maria João, Fernandes, Carlos, Nunes, Rute, Li, Wei, Santos, Hélder A., Borges, Fernanda, Sarmento, Bruno

“…[Display omitted] The human immunodeficiency virus (HIV) uses the brain as reservoir, which turns it as a promising target to fight this pathology…”
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Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood–Brain Barrier by Fernandes, Carlos, Pinto, Miguel, Martins, Cláudia, Gomes, Maria João, Sarmento, Bruno, Oliveira, Paulo J, Remião, Fernando, Borges, Fernanda

“…The uptake and transport of dietary antioxidants remains the most important setback for their application in therapy. To overcome the limitations, a…”
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Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders by Moura, Rui Pedro, Carvalho, Eva Daniela, Martins, Cláudia, des Rieux, Anne, Pêgo, Ana Paula, Sarmento, Bruno

“…Demyelinating disorders, with a particular focus on multiple sclerosis (MS), have a multitude of detrimental cognitive and physical effects on the patients…”
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Promoting coexistence with jaguars and pumas in the Caatinga: two approaches to reach school children by Dinis, Afonso, Rainho, Ana, de Campos, Cláudia B., Martins, Cláudia S. G.

“…Coexistence education is essential in resolving human-wildlife conflicts. Two educational interventions were assessed among school children to understand the…”
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Stimuli‐Responsive Multifunctional Nanomedicine for Enhanced Glioblastoma Chemotherapy Augments Multistage Blood‐to‐Brain Trafficking and Tumor Targeting by Martins, Cláudia, Araújo, Marco, Malfanti, Alessio, Pacheco, Catarina, Smith, Stuart J., Ucakar, Bernard, Rahman, Ruman, Aylott, Jonathan W., Préat, Véronique, Sarmento, Bruno

“…Minimal therapeutic advances have been achieved over the past two decades for glioblastoma (GBM), which remains an unmet clinical need. Here, hypothesis‐driven…”
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Statistical learning and spelling: Evidence from Brazilian prephonological spellers by Treiman, Rebecca, Cardoso-Martins, Cláudia, Pollo, Tatiana Cury, Kessler, Brett

“…We analyzed the spelling attempts of Brazilian children (age 3 years, 3 months to 6 years, 0 months) who were prephonological spellers, in that they wrote…”
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