Search Results - "Martins, C. B."
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Recent Advances in Co-Former Screening and Formation Prediction of Multicomponent Solid Forms of Low Molecular Weight Drugs
Published in Pharmaceutics (22-08-2023)“…Multicomponent solid forms of low molecular weight drugs, such as co-crystals, salts, and co-amorphous systems, are a result of the combination of an active…”
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New forms of old drugs: improving without changing
Published in Journal of pharmacy and pharmacology (01-06-2015)“…Objectives In a short approach, we want to present the improvements that have recently been done in the world of new solid forms of known active pharmaceutical…”
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Cellular dynamics as a marker of normal-to-cancer transition in human cells
Published in Scientific reports (29-11-2023)“…Normal-to-cancer (NTC) transition is known to be closely associated to cell´s biomechanical properties which are dependent on the dynamics of the intracellular…”
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Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide
Published in Chemical science (Cambridge) (25-10-2023)“…Polyamorphism has been a controversial and highly debated solid-state phenomenon in both material and pharmaceutical communities. Although some evidence of…”
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Insight into the Structure and Properties of Novel Imidazole-Based Salts of Salicylic Acid
Published in Molecules (Basel, Switzerland) (15-11-2019)“…The preparation of new active pharmaceutical ingredient (API) multicomponent crystal forms, especially co-crystals and salts, is being considered as a reliable…”
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The Lisbon Supramolecular Green Story: Mechanochemistry towards New Forms of Pharmaceuticals
Published in Molecules (Basel, Switzerland) (11-06-2020)“…This short review presents and highlights the work performed by the Lisbon Group on the mechanochemical synthesis of active pharmaceutical ingredients (APIs)…”
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Packing Interactions and Physicochemical Properties of Novel Multicomponent Crystal Forms of the Anti-Inflammatory Azelaic Acid Studied by X‑ray and Solid-State NMR
Published in Crystal growth & design (06-01-2016)“…The reactivity of the active pharmaceutical ingredient azelaic acid (AA) with carboxylic acid, alcohol, amine, and amide based co-formers was screened. Five…”
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Usnic acid potassium salt: an alternative for the control of Biomphalaria glabrata (Say, 1818)
Published in PloS one (06-11-2014)“…In Brazil, the snail Biomphalaria glabrata is the most important vector of schistosomiasis due to its wide geographical distribution, high infection rate and…”
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Curcumin as a promising antifungal of clinical interest
Published in Journal of antimicrobial chemotherapy (01-02-2009)“…Objectives The antifungal activity of curcumin was evaluated against 23 fungi strains and its in vitro inhibitory effect on the adhesion of Candida species to…”
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MechanoAPI‐ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis
Published in ChemSusChem (10-04-2017)“…An alternative, efficient, and green synthetic strategy for the preparation of pharmaceutical ionic liquids using mechanochemistry (MechanoAPI‐ILs) is…”
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Cladonia verticillaris (lichen) indicates negative impacts derived from the combustion of biodiesel blends: an alert for the environmental management for biofuels use
Published in Environmental monitoring and assessment (01-12-2021)“…The use of biodiesel blends with petroleum diesel in vehicular engines demands the evaluation of the possible impacts and effects of the gases emitted from…”
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Volatile Organic Compounds of Conspecific-Damaged Eucalyptus benthamii Influence Responses of Mated Females of Thaumastocoris peregrinus
Published in Journal of chemical ecology (01-05-2013)“…Plants respond to herbivory by synthesizing and releasing novel blends of volatile organic compounds (VOCs). Natural enemies are attracted to these VOCs, but…”
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Carbamazepine Dihydroxybenzoic Acid Cocrystals: Exploring Packing Interactions and Reaction Kinetics
Published in Crystal growth & design (01-12-2021)“…Herein, we present the mechanochemical formation of three new cocrystals containing the active pharmaceutical ingredient carbamazepine and dihydroxybenzoic…”
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Understanding Polymorphic Control of Pharmaceuticals Using Imidazolium-Based Ionic Liquid Mixtures as Crystallization Directing Agents
Published in Crystal growth & design (01-02-2017)“…Imidazolium-based room temperature ionic liquids (RTILs) were tested to assess their ability to control molecular polymorphic behavior. Mixtures of RTILs with…”
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Enhancing Adamantylamine Solubility through Salt Formation: Novel Products Studied by X‑ray Diffraction and Solid-State NMR
Published in Crystal growth & design (06-03-2019)“…The reactivity of the neuroleptic drug adamantylamine toward aliphatic carboxylic acids, sulfone derivatives, and aromatic amino acids was screened for the…”
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Formation Mechanism of a Nano‐Ring of Bismuth Cations and Mono‐Lacunary Keggin‐Type Phosphomolybdate
Published in Chemistry : a European journal (11-05-2022)“…A new hetero‐bimetallic polyoxometalate (POM) nano‐ring was synthesized in a one‐pot procedure. The structure consists of tetrameric units containing four…”
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Mechanochemical N‑Chlorination Reaction of Hydantoin: In Situ Real-Time Kinetic Study by Powder X‑ray Diffraction and Raman Spectroscopy
Published in ACS sustainable chemistry & engineering (20-09-2021)“…Mechanochemistry has become a valuable tool for the synthesis of new molecules, especially in the field of organic chemistry. In the present work, we…”
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A novel approach for the treatment of pelvic abscess: transrectal endoscopic drainage facilitated by transanal endoscopic microsurgery access
Published in Surgical endoscopy (01-09-2012)“…Background Postoperative pelvic abscesses in patients submitted to colorectal surgery are challenging. The surgical approach may be too risky, and image-guided…”
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Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid
Published in TheScientificWorld (2015)“…Leishmaniasis is considered by the World Health Organization as one of the infectious parasitic diseases endemic of great relevance and a global public health…”
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Does Clinical Treatment with Phenylbutazone and Meloxicam in the Pre‐ovulatory Period Influence the Ovulation Rate in Mares?
Published in Reproduction in domestic animals (01-10-2015)“…The presence of anovulatory haemorrhagic follicles during the oestrous cycle of mares causes financial impacts, slowing conception and increasing the number of…”
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