Cytomorphological criteria, subclassifications of endocervical glandular cell abnormalities, and histopathological outcome: A frequency study

The objective of this study was to evaluate the frequency and the significance of cytomorphological criteria defined in studies as being predictive of neoplasia in cervical smears of women with a cytological diagnosis of atypical glandular cells (AGC) or adenocarcinoma in situ (AIS). Women (n = 103)...

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Published in:	Diagnostic cytopathology Vol. 38; no. 11; pp. 806 - 810
Main Authors:	Nora, Letisa Comparin Dalla, Ázara, Cinara Zago Silveira, de Sousa Pace, Evelinne Leonel, Martins, Cássio Melo, Zeferino, Luiz Carlos, do Amaral Westin, Maria Cristina, Derchain, Sophie Françoise, Rabelo-Santos, Silvia Helena
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-11-2010
Subjects:	adenocarcinoma in situ atypical glandular cells Cervical Intraepithelial Neoplasia - classification Cervical Intraepithelial Neoplasia - pathology cervical smear Cervix Uteri - pathology cytomorphological criteria Female Humans neoplasia Uterine Cervical Neoplasms - classification Uterine Cervical Neoplasms - pathology Vaginal Smears
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Summary:	The objective of this study was to evaluate the frequency and the significance of cytomorphological criteria defined in studies as being predictive of neoplasia in cervical smears of women with a cytological diagnosis of atypical glandular cells (AGC) or adenocarcinoma in situ (AIS). Women (n = 103) with cytological findings suggestive of AGC or AIS, whose diagnoses were later established by histopathology, were included in the study. The criteria analyzed and classified as present or absent in cervical smears previously classified as AGC‐NOS (not otherwise specified), AGC‐FN (favor neoplasia), or AIS were as follows: irregular nuclear membranes; scanty cytoplasm; dyskeratotic cells; increased nuclear/cytoplasmic ratio; nucleoli; overlapping; papillary clusters, feathering; loss of polarity; nuclear enlargement; coarsely granular chromatin; and pseudostratified strips. Histopathology resulted in neoplastic diagnoses in 55 cases (53.3%) and nonneoplastic diagnoses in 48 cases (46.6%). Coarsely granular chromatin was observed in 62.5% of cases with a diagnosis of neoplasia. Feathering was present in 80% of cases of histopathological AIS. Loss of polarity and coarsely granular chromatin were significantly associated with neoplastic diagnosis considering all subcategories of glandular abnormalities diagnosis. In AGC‐SOE subclassification, coarsely granular chromatin was significantly associated with neoplastic diagnosis. The presence of nucleoli was significantly associated with neoplastic diagnosis in cervical smears qualified as AGC‐FN and AIS. Nuclear enlargement, increased nuclear/cytoplasmic ratio, coarsely granular chromatin and overlapping cells were found in all the subclassifications of glandular cell abnormalities irrespective of the histopathological results. Chromatin aspects, polarity, and presence of nucleoli can predict neoplasia. Diagn. Cytopathol. 2010;38:806‐810. © 2010 Wiley‐Liss, Inc.
Bibliography:	istex:F9D17F77C90B2929E03492DF970190DAF6F1BEB5 ark:/67375/WNG-KH8SR6JV-S ArticleID:DC21295 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	8755-1039 1097-0339
DOI:	10.1002/dc.21295