Search Results - "Martins, André F"
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Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn2+ Ions
Published in Journal of the American Chemical Society (19-12-2018)“…It has been demonstrated that divalent zinc ions packaged with insulin in β-cell granules can be detected by MRI during glucose-stimulated insulin secretion…”
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2
Basic MR relaxation mechanisms and contrast agent design
Published in Journal of magnetic resonance imaging (01-09-2015)“…The diagnostic capabilities of magnetic resonance imaging (MRI) have undergone continuous and substantial evolution by virtue of hardware and software…”
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3
Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI
Published in Inorganic chemistry (15-02-2021)“…A Mn(II)-based zinc-sensitive MRI contrast agent, MnPyC3A–BPEN, was prepared, characterized, and applied in imaging experiments to detect glucose-stimulated…”
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Amplifying the Sensitivity of Zinc(II) Responsive MRI Contrast Agents by Altering Water Exchange Rates
Published in Journal of the American Chemical Society (11-11-2015)“…Given the known water exchange rate limitations of a previously reported Zn(II)-sensitive MRI contrast agent, GdDOTA-diBPEN, new structural targets were…”
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5
Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor
Published in Molecular pharmaceutics (06-08-2018)“…Superoxide overproduction is known to occur in multiple disease states requiring critical care; yet, noninvasive detection of superoxide in deep tissue remains…”
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Lanthanide-Based T 2ex and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents
Published in Angewandte Chemie International Edition (22-12-2017)“…The CEST and T /T relaxation properties of a series of Eu and Dy DOTA-tetraamide complexes with four appended primary amine groups are measured as a function…”
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Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents
Published in Inorganic chemistry (21-03-2016)“…EuDOTA-tetraamide complexes as paraCEST agents offer an attractive platform for designing biological sensors and responsive agents. The early versions of these…”
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Lanthanide‐Based T2ex and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents
Published in Angewandte Chemie International Edition (22-12-2017)“…The CEST and T1/T2 relaxation properties of a series of Eu3+ and Dy3+ DOTA‐tetraamide complexes with four appended primary amine groups are measured as a…”
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9
Enantiomeric Recognition of d- and l‑Lactate by CEST with the Aid of a Paramagnetic Shift Reagent
Published in Journal of the American Chemical Society (06-12-2017)“…A previous report demonstrated that EuDO3A could be used as an NMR shift reagent for imaging extracellular lactate produced by cancer cells using CEST imaging…”
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10
Unexpected Changes in the Population of Coordination Isomers for the Lanthanide Ion Complexes of DOTMA–Tetraglycinate
Published in Inorganic chemistry (19-09-2016)“…Lanthanide complexes with DOTA–tetraglycinate (DOTA-(gly)4) heavily favor the square antiprismatic (SAP) coordination isomer in aqueous solution, a structural…”
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11
Efficient Methods for Natural Language Processing: A Survey
Published in Transactions of the Association for Computational Linguistics (12-07-2023)“…Recent work in natural language processing (NLP) has yielded appealing results from scaling model parameters and training data; however, using only scale to…”
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Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors
Published in Molecular cancer (15-12-2023)“…Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor…”
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Bridging the Gap: A Survey on Integrating (Human) Feedback for Natural Language Generation
Published in Transactions of the Association for Computational Linguistics (19-12-2023)“…Natural language generation has witnessed significant advancements due to the training of large language models on vast internet-scale datasets. Despite these…”
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14
A Protein-Based Biosensor for Detecting Calcium by Magnetic Resonance Imaging
Published in ACS sensors (24-09-2021)“…Calcium-responsive contrast agents for magnetic resonance imaging (MRI) offer a promising approach for noninvasive brain-wide monitoring of neural activity at…”
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15
Zinc as an Imaging Biomarker of Prostate Cancer
Published in Israel journal of chemistry (01-09-2017)“…Zinc has long been the focus of many biological investigations because of its essential role in biology including a catalytic role in many enzymes, a…”
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New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties
Published in Dalton transactions : an international journal of inorganic chemistry (07-05-2013)“…There is a growing interest in the development of new medical diagnostic tools with higher sensibility and less damage for the patient body, namely on imaging…”
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Impact of dietary zinc on stimulated zinc secretion MRI in the healthy and malignant mouse prostate
Published in Npj imaging (06-11-2024)“…Previous studies have shown that the zinc-responsive MRI probe, GdL1, can distinguish healthy versus malignant prostate tissues based upon differences in zinc…”
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18
Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS
Published in iScience (19-04-2024)“…The extracellular superoxide dismutases (ecSODs) secreted by Microplitis bicoloratus reduce the reactive oxygen species (ROS) stimulated by the Microplitis…”
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Enhancing r 1 Relaxivity in GdDOTA-Monoamide Complexes through Polar Group-Mediated Ordering of Second-Sphere Water Molecules
Published in Inorganic chemistry (04-03-2024)“…This study was designed to test whether the single appended phosphonate group in GdDOTA-1AmP is sufficient for catalyzing the exchange of proton from the…”
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Enhancing r1 Relaxivity in GdDOTA-Monoamide Complexes through Polar Group-Mediated Ordering of Second-Sphere Water Molecules
Published in Inorganic chemistry (04-03-2024)“…This study was designed to test whether the single appended phosphonate group in GdDOTA-1AmP is sufficient for catalyzing the exchange of proton from the…”
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