Search Results - "Martinowitz, Uri"

Long-acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial by Santagostino, Elena, Martinowitz, Uri, Lissitchkov, Toshko, Pan-Petesch, Brigitte, Hanabusa, Hideji, Oldenburg, Johannes, Boggio, Lisa, Negrier, Claude, Pabinger, Ingrid, von Depka Prondzinski, Mario, Altisent, Carmen, Castaman, Giancarlo, Yamamoto, Koji, Álvarez-Roman, Maria-Teresa, Voigt, Christine, Blackman, Nicole, Jacobs, Iris

“…A global phase 3 study evaluated the pharmacokinetics, efficacy, and safety of recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP)…”
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Four Decades of Carrier Detection and Prenatal Diagnosis in Hemophilia A: Historical Overview, State of the Art and Future Directions by Dardik, Rima, Janczar, Szymon, Lalezari, Shadan, Avishai, Einat, Levy-Mendelovich, Sarina, Barg, Assaf Arie, Martinowitz, Uri, Babol-Pokora, Katarzyna, Mlynarski, Wojciech, Kenet, Gili

“…Hemophilia A (HA), a rare recessive X-linked bleeding disorder, is caused by either deficiency or dysfunction of coagulation factor VIII (FVIII) resulting from…”
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The impact of thrombin generation and rotation thromboelastometry on assessment of severity of factor XI deficiency by Livnat, Tami, Shenkman, Boris, Martinowitz, Uri, Zivelin, Ariella, Dardik, Rima, Tamarin, Ilia, Mansharov, Rachel, Budnik, Ivan, Salomon, Ophira

“…Abstract The phenotype of bleeding in patients with severe FXI deficiency is unpredictable and unlike other bleeding disorders, it is not directly correlated…”
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Differential Roles of Fibrinogen and von Willebrand Factor on Clot Formation and Platelet Adhesion in Reconstituted and Immune Thrombocytopenia by Misgav, Mudi, Shenkman, Boris, Budnik, Ivan, Einav, Yulia, Martinowitz, Uri

“…Bleeding tendencies in immune thrombocytopenia (ITP) do not always correlate with the number of platelets, suggesting platelet function variation. We used a…”
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The association between unemployment and treatment among adults with hemophilia by Qvigstad, Christian, Sørensen, Lars Q., Tjønnfjord, Geir E., Holme, Pål André, Pabinger, Ingrid, Hermans, Cedric, Roseline d’Oiron, Klamroth, Robert, Oldenburg, Johannes, Marquardt, Natascha, Staritz, Peter, Katsarou, Olga, Martinowitz, Uri, Lubetsky, Aharon, Kenet, Gili, Tagliaferri, Annarita, Mancuso, Maria Elisa, Schutgens, Roger, HolmE, Pål André, Windyga, Jerzy, Zupan, Irena, Yuste, Victor Jimenez, Nunez, Ramiro, de Moerloose, Philippe, Berntorp, Erik, Astermark, Jan, Tait, Campbell, Dolan, Gerry

“…People with hemophilia often experience pain and suffer from comorbidities related to their bleeding disorder. Consequently, unemployment due to disability is…”
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Continuous infusion of coagulation factors: current opinion by Batorova, Angelika, Martinowitz, Uri

“…PURPOSE OF REVIEWTo review the most recent reports on continuous infusion of coagulation factors, focusing on the current issues relating to this mode of…”
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Survival of hepatitis C-infected haemophilia patients is predicted by presence of cirrhosis but not by anti-viral treatment by Maor, Yaakov, Schapiro, Jonathan M, Bashari, Dalia, Martinowitz, Uri

“…AbstractBackground/Purpose. Hepatitis C (HCV) is a major cause of morbidity and mortality in haemophilia patients who received clotting factor concentrates…”
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The Use of Fibrin Tissue Adhesive to Reduce Blood Loss and the Need for Blood Transfusion After Total Knee Arthroplasty. A Prospective, Randomized, Multicenter Study by LEVY, OFER, MARTINOWITZ, URI, ORAN, ARIEL, TAUBER, CHANAN, HOROSZOWSKI, HENRI

“…BackgroundTotal knee arthroplasty is associated with major postoperative blood loss of approximately 800 to 1200 milliliters, and blood transfusion is…”
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Correction of Hemophilia as a Proof of Concept for Treatment of Monogenic Diseases by Fetal Spleen Transplantation by Aronovich, Anna, Tchorsh, Dalit, Katchman, Helena, Eventov-Friedman, Smadar, Shezen, Elias, Martinowitz, Uri, Blazar, Bruce R., Cohen, Sivan, Tal, Orna, Reisner, Yair

“…Previous clinical attempts to correct genetic deficiencies such as hemophilia or Gaucher disease by transplantation of allogeneic spleen were associated with…”
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Continuous infusion of recombinant factor VIIa for surgery in patients with deficiency of factor VII by Schulman, Sam, Tjønnfjord, Geir E, Wallensten, Richard, Martinowitz, Uri, Kenet, Gill

“…The administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in…”
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Enhancement of pig embryonic implants in factor VIII KO mice: a novel role for the coagulation cascade in organ size control by Aronovich, Anna, Tchorsh, Dalit, Shezen, Elias, Rosen, Chava, Klionsky, Yael, Cohen, Sivan, Tal, Orna, Martinowitz, Uri, Katchman, Helena, Eventov-Friedman, Smadar, Amariglio, Ninette, Jacob-Hirsch, Jasmine, Rechavi, Gideon, Reisner, Yair

“…Very little is known about the mechanisms that contribute to organ size differences between species. In the present study, we used a mouse model of embryonic…”
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Phase I/II, open-label, multicenter, safety, efficacy and PK study of a recombinant coagulation factor IX albumin fusion protein (rIX-FP) in subjects with hemophilia B by Martinowitz, Uri, Lubetsky, Aaron

“…Abstract Recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) is a novel recombinant albumin fusion protein designed to extend the…”
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Effects of increasing doses of activated recombinant factor VII on haemostatic parameters in swine by Pusateri, Anthony E, Ryan, Kathy L, Delgado, Angel V, Martinez, Raul S, Uscilowicz, John M, Cortez, Douglas S, Martinowitz, Uri

“…This study examined dose-response relationships between activated recombinant factor VII (rFVIIa) and (1) in vivo haemostasis and (2) in vitro measures of…”
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Safety and efficacy of continuous infusion of a combined factor VIII-von Willebrand factor (vWF) concentrate (Haemate-P) in patients with von Willebrand disease by Lubetsky, A, Schulman, S, Varon, D, Martinowitz, U, Kenet, G, Gitel, S, Inbal, A

“…We studied the safety and efficacy of treatment with continuous infusion of a von Willebrand factor (vWF) concentrate Haemate-P in patients with von Willebrand…”
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Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force by MARTINOWITZ, U., MICHAELSON, M.

“…Background: Recombinant activated factor VII (rFVIIa) has been approved by the U.S. Food and Drug Administration (FDA) for almost a decade for hemophilic…”
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Stability of factor VIII concentrates after reconstitution by Schulman, S, Gitel, S, Martinowitz, U

“…Adjusted-dose continuous infusion of factor VIII (F VIII) has recently been shown to reduce the doses of the factor in patients undergoing surgery by 50-75%…”
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Recombinant Activated Factor VII for Adjunctive Hemorrhage Control in Trauma by Martinowitz, Uri, Kenet, Gili, Segal, Eran, Luboshitz, Jacob, Lubetsky, Aharon, Ingerslev, Jorgen, Lynn, Mauricio

“…BACKGROUNDRecombinant activated factor VII (rFVIIa) was approved for treatment of hemorrhages in patients with hemophilia who develop inhibitors to factors…”
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Role of clinical and laboratory parameters for treatment choice in patients with inherited FVII deficiency undergoing surgical procedures: evidence from the STER registry by Di Minno, Matteo N. D., Napolitano, Mariasanta, Dolce, Alberto, Mariani, Guglielmo, Auerswald, Guenter, Batorova, Angelica, Bernardi, Francesco, Di Minno, Giovanni, Giansilly‐Balizot, Muriel, Ingerslev, Jorgen, Martinowitz, Uri, Morfini, Massimo, Pinotti, Mirko, Shapiro, Amy, Siragusa, Sergio, Schved, Jean Francois, Sørensen, Benny

“…Summary Perioperative bleeding is a major concern in patients with factor VII (FVII) deficiency. Evaluating data of 95 FVII‐deficient patients undergoing 110…”
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Long-Term Use of Coagulation Factor IX (Recombinant) Albumin Fusion Protein (rIX-FP) in Previously Treated Patients with Hemophilia B in the Prolong-9FP Program by Lubetsky, Aaron, Martinowitz, Uri, Lissitchkov, Toshko, Voigt, Christine, Wolko, Denise, Jacobs, Iris C., Santagostino, Elena

“…A fusion protein genetically linking recombinant human coagulation FIX with recombinant human albumin (rIX-FP) has been developed with an improved PK profile,…”
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Single-Dose Recombinant Activated Factor VII Therapy in Hemophilia Patients With Inhibitors by Kenet, Gili, Martinowitz, Uri

“…Recombinant activated factor VII (rFVIIa; NovoSeven® , Novo Nordisk, Bagsværd, Denmark) is well established as an effective hemostatic agent for the management…”
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