Search Results - "Martinic, Marianne"

ACT‐1004‐1239, a first‐in‐class CXCR7 antagonist with both immunomodulatory and promyelinating effects for the treatment of inflammatory demyelinating diseases by Pouzol, Laetitia, Baumlin, Nadège, Sassi, Anna, Tunis, Mélanie, Marrie, Julia, Vezzali, Enrico, Farine, Hervé, Mentzel, Ulrich, Martinic, Marianne M.

“…Current strategies for the treatment of demyelinating diseases such as multiple sclerosis (MS) are based on anti‐inflammatory or immunomodulatory drugs. Those…”
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Resolution of a chronic viral infection after interleukin-10 receptor blockade by Ejrnaes, Mette, Filippi, Christophe M, Martinic, Marianne M, Ling, Eleanor M, Togher, Lisa M, Crotty, Shane, von Herrath, Matthias G

“…A defining characteristic of persistent viral infections is the loss and functional inactivation of antiviral effector T cells, which prevents viral clearance…”
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Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity by Guerau-de-Arellano, Mireia, Martinic, Marianne, Benoist, Christophe, Mathis, Diane

“…There has long been conceptual and experimental support for, but also challenges to, the notion that the initial period of the immune system's development is…”
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Combination treatment of a novel CXCR3 antagonist ACT-777991 with an anti-CD3 antibody synergistically increases persistent remission in experimental models of type 1 diabetes by Christen, Urs, Pouzol, Laetitia, Tunis, Mélanie, Sassi, Anna, Tondello, Camilla, Bayer, Monika, Hintermann, Edith, Strasser, Daniel S, Schuldes, Sabrina, Mentzel, Ulrich, Martinic, Marianne M

“…Abstract Treatment of patients with recent-onset type 1 diabetes with an anti-CD3 antibody leads to the transient stabilization of C-peptide levels in…”
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ACKR3 Antagonism Enhances the Repair of Demyelinated Lesions Through Both Immunomodulatory and Remyelinating Effects by Pouzol, Laetitia, Sassi, Anna, Tunis, Mélanie, Zurbach, Anaïs, Baumlin, Nadège, Gnerre, Carmela, Strasser, Daniel S., Marrie, Julia, Vezzali, Enrico, Martinic, Marianne M.

“…Addressing inflammation, demyelination, and associated neurodegeneration in inflammatory demyelinating diseases like multiple sclerosis (MS) remains…”
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Cenerimod, a selective S1P1 receptor modulator, improves organ-specific disease outcomes in animal models of Sjögren’s syndrome by Gerossier, Estelle, Nayar, Saba, Froidevaux, Sylvie, Smith, Charlotte G., Runser, Celine, Iannizzotto, Valentina, Vezzali, Enrico, Pierlot, Gabin, Mentzel, Ulrich, Murphy, Mark J., Martinic, Marianne M., Barone, Francesca

“…Abstract Background Sjögren’s syndrome is a systemic autoimmune disease characterized by immune cells predominantly infiltrating the exocrine glands and…”
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CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis by Pouzol, Laetitia, Sassi, Anna, Baumlin, Nadège, Tunis, Mélanie, Strasser, Daniel S., Lehembre, François, Martinic, Marianne M.

“…Loss of control in the trafficking of immune cells to the inflamed lung tissue contributes to the pathogenesis of life-threatening acute lung injury (ALI) and…”
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Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies by Meyer, Emmanuel A., Äänismaa, Päivi, Ertel, Eric A., Hühn, Eva, Strasser, Daniel S., Rey, Markus, Murphy, Mark J., Martinic, Marianne M., Pouzol, Laetitia, Froidevaux, Sylvie, Keller, Marcel P., Caroff, Eva

“…The CXCR3 chemokine receptor is a G protein-coupled receptor mainly expressed on immune cells from the lymphoid lineage, including activated T cells. Binding…”
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The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8 + Thymocyte Selection by Martinic, Marianne M, Caminschi, Irina, O'Keeffe, Meredith, Thinnes, Therese C, Grumont, Raelene, Gerondakis, Steve, McKay, Dianne B, Nemazee, David, Gavin, Amanda L

“…Nucleotide-binding and oligomerization domain (NOD)-like receptors NOD1 and NOD2 are cytosolic innate immune receptors that recognize microbial peptidoglycans…”
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A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy by Coppieters, Ken, Martinic, Marianne M, Kiosses, William B, Amirian, Natalie, von Herrath, Matthias

“…Type 1 diabetes (T1D) is characterized by the immune-mediated destruction of beta cells in the pancreas. Little is known about the in vivo dynamic interactions…”
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Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis by Pouzol, Laetitia, Piali, Luca, Bernard, Claude Ca, Martinic, Marianne M, Steiner, Beat, Clozel, Martine

“…Despite the recent approval of new oral therapies for the treatment of multiple sclerosis (MS), a significant percentage of patients are still not free from…”
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Transection of Major Histocompatibility Complex Class I-Induced Neurites by Cytotoxic T Lymphocytes by Medana, Isabelle, Martinic, Marianne A., Wekerle, Hartmut, Neumann, Harald

“…Damage to neurites with transection of axons and spheroid formation is commonly noted in the central nervous system during viral and autoimmune diseases such…”
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Real-time imaging of the pancreas during development of diabetes by Martinic, Marianne M, von Herrath, Matthias G

“…Type 1 diabetes (T1D) is the most common autoimmune disease affecting almost 20 million people worldwide. T1D is thought to be caused by autoaggressive T cells…”
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Preclinical to clinical translation of cenerimod, a novel S1P 1 receptor modulator, in systemic lupus erythematosus by Strasser, Daniel S, Froidevaux, Sylvie, Sippel, Virginie, Gerossier, Estelle, Grieder, Ursula, Pierlot, Gabin M, Kieninger-Graefitsch, Andrea, Vezzali, Enrico, Stalder, Anna K, Renault, Bérengère, Ryge, Jesper, Hart, Aaron, Mentzel, Ulrich, Groenen, Peter M A, Keller, Marcel P, Trendelenburg, Marten, Martinic, Marianne M, Murphy, Mark J

“…Objectives: SLE is an autoimmune disease characterised by aberrant lymphocyte activation and autoantibody production. This study provides an in-depth…”
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Novel strategies to eliminate persistent viral infections by Martinic, Marianne M, von Herrath, Matthias G

“…Infection with viruses that have the capacity to modulate or evade the immune response can result in persistence, which can lead to a variety of chronic…”
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MHC class I‐restricted killing of neurons by virus‐specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway by Medana, Isabelle M., Gallimore, Awen, Oxenius, Annette, Martinic, Marianne M.A., Wekerle, Hartmut, Neumann, Harald

“…Induction of MHC class I genes in neurons of the central nervous system requires signals by pro‐inflammatory cytokines, in particular IFN‐γ, and the blockade…”
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LO-016 The multifaceted immunomodulatory properties of cenerimod, a selective S1P1 receptor modulator, target three key aspects of SLE pathogenesis by Hoyler, Thomas F, Strasser, Daniel S, Ouali Berkani, Cahuzac, Clelia, Cornelisse, Peter, Murphy, Mark J, Martinic, Marianne M

“…BackgroundSystemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by aberrant lymphocyte activation and autoantibodies. Formation and…”
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CpG-Containing Oligonucleotides Are Efficient Adjuvants for Induction of Protective Antiviral Immune Responses with T-Cell Peptide Vaccines by Oxenius, A, Martinic, M M, Hengartner, H, Klenerman, P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Expression level of a pancreatic neo-antigen in beta cells determines degree of diabetes pathogenesis by Martinic, Marianne M, Huber, Christoph, Coppieters, Ken, Oldham, Janine E, Gavin, Amanda L, von Herrath, Matthias G

“…Abstract It is not fully understood how the expression level of autoantigens in beta cells impacts autoimmune diabetes (T1D) development. Earlier studies using…”
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Control of graft‐versus‐host disease by regulatory T cells: Which level of antigen specificity? by Martinic, Marianne M., von Herrath, Matthias G.

“…Regulatory T cells (Tregs) are essential to suppress harmful self‐reactive T cell responses. A paper in this issue of the European Journal of Immunology…”
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