Acute kidney injury in visceral leishmaniasis: a cohort of 10 patients admitted to a specialized intensive care unit in northeast of Brazil

To describe co-infections, clinical manifestations, comorbidities and outcome of patients with visceral leishmaniasis and AKI. This is a case study with ten patients with confirmed diagnosis of VL admitted to the reference ICU of Northeast of Brazil during 6 years, with renal injury. Clinical and la...

Full description

Saved in:

Bibliographic Details
Published in:	Asian Pacific journal of tropical disease Vol. 3; no. 1; pp. 41 - 46
Main Authors:	Daher, Elizabeth F., Sampaio, Aline Menezes, Martiniano, Lorena Vasconcelos M., Vieira, Ana Patrícia Freitas, Silva, Geraldo B.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-02-2013 Asian Pacific Tropical Medicine Press
Subjects:	Clinical Researches HIV Intensive care unit Kala-azar Kidney disease Leprosy Visceral leishmaniasis Kidney disease Leprosy Kala-azar HIV Visceral leishmaniasis Intensive care unit
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To describe co-infections, clinical manifestations, comorbidities and outcome of patients with visceral leishmaniasis and AKI. This is a case study with ten patients with confirmed diagnosis of VL admitted to the reference ICU of Northeast of Brazil during 6 years, with renal injury. Clinical and laboratory parameters were evaluated in admission, period of hospitalization and outcome. This study found 10 patients with VL in a group of 253 patients admitted to the ICU with AKI. The main signs and symptoms presented at admission were weight loss, fever, splenomegaly, jaundice, anorexia, asthenia, bleeding and vomits. The main co-infections were: AIDS, tuberculosis and leprosy. Patients were classified in RIFLE criteria. RIFLE-F patients were younger and had a longer time between onset of symptoms and hospital admission. Death was observed in 60% of cases. The causes of death were septic shock, respiratory insufficiency and multiple organ dysfunction. AKI is an important complication in VL. The progression of the disease and their complications can achieve high level of severity, even in the absence of comorbidities or co-infections. The high mortality in this group alerts to the importance of adequate management of these patients.
ISSN:	2222-1808 2222-1808
DOI:	10.1016/S2222-1808(13)60009-2