Search Results - "Martinez, Fernando D"

Early-Life Origins of Chronic Obstructive Pulmonary Disease by Martinez, Fernando D

“…The conventional thinking about COPD is that exposures in adult life, such as smoking, lead to a low FEV 1 :FVC ratio, the physiological hallmark of COPD. In…”
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Early Origins of Asthma. Role of Microbial Dysbiosis and Metabolic Dysfunction by Martinez, Fernando D, Guerra, Stefano

“…Streptococcus colonization at 2 months of age was significantly associated with chronic wheeze at 5 years of age. Because colonization with Streptococcus was…”
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Asthma-associated differences in microbial composition of induced sputum by Marri, Pradeep Reddy, PhD, Stern, Debra A., MS, Wright, Anne L., PhD, Billheimer, Dean, PhD, Martinez, Fernando D., MD

“…Background It is increasingly evident that microbial colonization of the respiratory tract might have a role in the pathogenesis of asthma. Objective We sought…”
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Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease by Lange, Peter, Celli, Bartolome, Agustí, Alvar, Boje Jensen, Gorm, Divo, Miguel, Faner, Rosa, Guerra, Stefano, Marott, Jacob Louis, Martinez, Fernando D, Martinez-Camblor, Pablo, Meek, Paula, Owen, Caroline A, Petersen, Hans, Pinto-Plata, Victor, Schnohr, Peter, Sood, Akshay, Soriano, Joan B, Tesfaigzi, Yohannes, Vestbo, Jørgen

“…It had been thought that most people with chronic obstructive pulmonary disease had normal lung function in mid-adult life and then lost it rapidly. In this…”
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Persistent Insomnia is Associated with Mortality Risk by Parthasarathy, Sairam, MD, Vasquez, Monica M., MPH, Halonen, Marilyn, PhD, Bootzin, Richard, PhD, Quan, Stuart F., MD, Martinez, Fernando D., MD, Guerra, Stefano, MD, PhD

“…Abstract Background Insomnia has been associated with mortality risk, but whether this association is different in subjects with persistent vs intermittent…”
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Recent progress on cheminformatics approaches to epigenetic drug discovery by Sessions, Zoe, Sánchez-Cruz, Norberto, Prieto-Martínez, Fernando D., Alves, Vinicius M., Santos, Hudson P., Muratov, Eugene, Tropsha, Alexander, Medina-Franco, José L.

“…•The interest in developing epigenetic drugs is substantially increasing.•We reviewed the recent epigenetics structure-activity relationships.•Epi-informatics…”
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Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study by Stern, Debra A, Morgan, Wayne J, Prof, Wright, Anne L, PhD, Guerra, Stefano, MD, Martinez, Fernando D, Prof

“…Summary Background Together with smoking, the lung function attained in early adulthood is one of the strongest predictors of chronic obstructive pulmonary…”
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Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study by Stern, Debra A, MS, Morgan, Wayne J, Prof, Halonen, Marilyn, Prof, Wright, Anne L, Prof, Martinez, Fernando D, Prof

“…Summary Background Incidence of asthma increases during early adulthood. We aimed to estimate the contributions of sex and early life factors to asthma…”
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Pneumonia in childhood and impaired lung function in adults: a longitudinal study by Chan, Johnny Y C, Stern, Debra A, Guerra, Stefano, Wright, Anne L, Morgan, Wayne J, Martinez, Fernando D

“…Diminished lung function and increased prevalence of asthma have been reported in children with a history of early lower respiratory illnesses (LRIs),…”
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A Distinct Low Lung Function Trajectory from Childhood to the Fourth Decade of Life by Berry, Cristine E, Billheimer, Dean, Jenkins, Isaac C, Lu, Zhenqiang J, Stern, Debra A, Gerald, Lynn B, Carr, Tara F, Guerra, Stefano, Morgan, Wayne J, Wright, Anne L, Martinez, Fernando D

“…Low maximally attained lung function increases the risk of chronic obstructive pulmonary disease irrespective of the subsequent rate of lung function decline…”
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The Role of the Lung Microbiome in Health and Disease: A National Heart, Lung, and Blood Institute Workshop Report by HUANG, Yvonne J, CHARLSON, Emily S, COLLMAN, Ronald G, COLOMBINI-HATCH, Sandra, MARTINEZ, Fernando D, SENIOR, Robert M

“…Study of the human lung microbiome in the context of pulmonary health and disease is an area of emerging research interest that is being driven by several…”
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Club Cell Secretory Protein Deficiency Leads to Altered Lung Function by Zhai, Jing, Insel, Michael, Addison, Kenneth J, Stern, Debra A, Pederson, William, Dy, Alane, Rojas-Quintero, Joselyn, Owen, Caroline A, Sherrill, Duane L, Morgan, Wayne, Wright, Anne L, Halonen, Marilyn, Martinez, Fernando D, Kraft, Monica, Guerra, Stefano, Ledford, Julie G

“…CC16 (club cell secretory protein-16), a member of the secretoglobin family, is one of the most abundant proteins in normal airway secretions and has been…”
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In Silico Exploration of the Trypanothione Reductase (TryR) of L. mexicana by Barrera-Téllez, Francisco J., Prieto-Martínez, Fernando D., Hernández-Campos, Alicia, Martínez-Mayorga, Karina, Castillo-Bocanegra, Rafael

“…Human leishmaniasis is a neglected tropical disease which affects nearly 1.5 million people every year, with Mexico being an important endemic region. One of…”
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New insights into the natural history of asthma: Primary prevention on the horizon by Martinez, Fernando D., MD

“…Recent studies of the natural history of asthma have shifted attention toward viral respiratory tract illness in early life as a major risk factor associated…”
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American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report by Woodruff, Prescott G, van den Berge, Maarten, Boucher, Richard C, Brightling, Christopher, Burchard, Esteban G, Christenson, Stephanie A, Han, MeiLan K, Holtzman, Michael J, Kraft, Monica, Lynch, David A, Martinez, Fernando D, Reddel, Helen K, Sin, Don D, Washko, George R, Wenzel, Sally E, Punturieri, Antonello, Freemer, Michelle M, Wise, Robert A

“…Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic obstructive lung diseases with an associated high burden of disease…”
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Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease by Santibáñez-Morán, Marisa G, López-López, Edgar, Prieto-Martínez, Fernando D, Sánchez-Cruz, Norberto, Medina-Franco, José L

“…The pandemic caused by SARS-CoV-2 (COVID-19 disease) has claimed more than 500 000 lives worldwide, and more than nine million people are infected…”
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Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo by Bosco, Anthony, PhD, Ehteshami, Samira, BS, Panyala, Sujatha, MS, Martinez, Fernando D., MD

“…Background Exacerbations are responsible for a substantial burden of morbidity and health care use in children with asthma. Most asthma exacerbations are…”
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Safety of Long-Acting Beta-Agonists — An Urgent Need to Clear the Air by Martinez, Fernando D

“…Dr. Fernando Martinez describes the evidence that indicates that regular treatment with long-acting beta-agonists is associated with increased risks of severe…”
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Asthma outcomes: Exacerbations by Fuhlbrigge, Anne, MD, MS, Peden, David, MD, MS, Apter, Andrea J., MD, MSc, MA, Boushey, Homer A., MD, Camargo, Carlos A., MD, DrPH, Gern, James, MD, Heymann, Peter W., MD, Martinez, Fernando D., MD, Mauger, David, PhD, Teague, William G., MD, Blaisdell, Carol, MD, MEd

“…Background The goals of asthma treatment include preventing recurrent exacerbations. Yet there is no consensus about the terminology for describing or defining…”
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Activity Landscape and Molecular Modeling to Explore the SAR of Dual Epigenetic Inhibitors: A Focus on G9a and DNMT1 by López-López, Edgar, Prieto-Martínez, Fernando D, Medina-Franco, José L

“…In this work we discuss the insights from activity landscape, docking and molecular dynamics towards the understanding of the structure-activity relationships…”
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