Search Results - "Martinelli, Joseph R"

Cu-Catalyzed Aerobic Oxidative N–N Coupling of Carbazoles and Diarylamines Including Selective Cross-Coupling by Ryan, Michael C, Martinelli, Joseph R, Stahl, Shannon S

“…A Cu-catalyzed method has been identified for aerobic oxidative dimerization of carbazoles and diarylamines to the corresponding N–N coupled bicarbazoles and…”
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Experimental Limiting Oxygen Concentrations for Nine Organic Solvents at Temperatures and Pressures Relevant to Aerobic Oxidations in the Pharmaceutical Industry by Osterberg, Paul M, Niemeier, Jeffry K, Welch, Christopher J, Hawkins, Joel M, Martinelli, Joseph R, Johnson, Thomas E, Root, Thatcher W, Stahl, Shannon S

“…Applications of aerobic oxidation methods in pharmaceutical manufacturing are limited in part because mixtures of oxygen gas and organic solvents often create…”
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Palladium-Catalyzed Aminocarbonylation of Aryl Chlorides at Atmospheric Pressure: The Dual Role of Sodium Phenoxide by Martinelli, Joseph R, Clark, Thomas P, Watson, Donald A, Munday, Rachel H, Buchwald, Stephen L

“…No pressure, no worries: A general, functional‐group‐tolerant, mild system for the Pd‐catalyzed carbonylation of aryl chlorides to the corresponding amides has…”
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Catalysts for Suzuki−Miyaura Coupling Processes:  Scope and Studies of the Effect of Ligand Structure by Barder, Timothy E, Walker, Shawn D, Martinelli, Joseph R, Buchwald, Stephen L

“…Suzuki−Miyaura coupling reactions of aryl and heteroaryl halides with aryl-, heteroaryl- and vinylboronic acids proceed in very good to excellent yield with…”
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Process Development of CuI/ABNO/NMI-Catalyzed Aerobic Alcohol Oxidation by Steves, Janelle E, Preger, Yuliya, Martinelli, Joseph R, Welch, Christopher J, Root, Thatcher W, Hawkins, Joel M, Stahl, Shannon S

“…An improved Cu/nitroxyl catalyst system for aerobic alcohol oxidation has been developed for the oxidation of functionalized primary and secondary alcohols to…”
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Palladium-Catalyzed Carbonylation Reactions of Aryl Bromides at Atmospheric Pressure: A General System Based on Xantphos by Martinelli, Joseph R, Watson, Donald A, Freckmann, Dominique M. M, Barder, Timothy E, Buchwald, Stephen L

“…A method for the Pd-catalyzed carbonylation of aryl bromides has been developed using Xantphos as the ligand. This method is effective for the direct synthesis…”
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Accelerating Reactions with Microreactors at Elevated Temperatures and Pressures: Profiling Aminocarbonylation Reactions by Murphy, Edward R., Martinelli, Joseph R., Zaborenko, Nikolay, Buchwald, Stephen L., Jensen, Klavs F.

“…Squeeze play: Pressurized microreactor systems greatly expand the range of reaction conditions and accelerate gas–liquid mass transfer. Heck aminocarbonylation…”
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The History of Flow Chemistry at Eli Lilly and Company by Johnson, Martin D., Braden, Timothy, Calvin, Joel R., Campbell Brewer, Alison, Cole, Kevin P., Frank, Scott, Kerr, Mark, Kjell, Doug, Kopach, Michael E., Martinelli, Joseph R., May, Scott. A., Rincon, Juan, White, Timothy D., Yates, Matthew H.

“…Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would…”
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Convenient Method for the Preparation of Weinreb Amides via Pd-Catalyzed Aminocarbonylation of Aryl Bromides at Atmospheric Pressure by Martinelli, Joseph R, Freckmann, Dominique M. M, Buchwald, Stephen L

“…The direct transformation of aryl bromides into the corresponding Weinreb amides via Pd-catalyzed aminocarbonylation at atmospheric pressure is reported…”
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A Rationally Designed Universal Catalyst for Suzuki-Miyaura Coupling Processes by Walker, Shawn D., Barder, Timothy E., Martinelli, Joseph R., Buchwald, Stephen L.

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Palladium-Catalyzed Carbonylation of Aryl Tosylates and Mesylates by Munday, Rachel H, Martinelli, Joseph R, Buchwald, Stephen L

“…A general protocol for the palladium-catalyzed carbonylation of aryl tosylates and mesylates to form esters has been developed using a catalyst system derived…”
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Free-Radical Deoxygenative Amination of Alcohols via Copper Metallaphotoredox Catalysis by Tsymbal, Artem V., Pipal, Robert W., Edwards, Grant A., Martinelli, Joseph R., Cabré, Albert, MacMillan, David W. C.

“…Alcohols are among the most abundant chemical feedstocks, yet they remain vastly underutilized as coupling partners in transition metal catalysis. Herein, we…”
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Mechanistic insights into copper-catalyzed aerobic oxidative coupling of N-N bonds by Ryan, Michael C, Kim, Yeon Jung, Gerken, James B, Wang, Fei, Aristov, Michael M, Martinelli, Joseph R, Stahl, Shannon S

“…Catalytic N-N coupling is a valuable transformation for chemical synthesis and energy conversion. Here, mechanistic studies are presented for two related…”
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Development and Scale-Up of a Continuous Aerobic Oxidative Chan–Lam Coupling by Campbell Brewer, Alison, Hoffman, Philip C, Martinelli, Joseph R, Kobierski, Michael E, Mullane, Nessa, Robbins, David

“…Despite the benefits of high atom economy and low cost, aerobic oxidations have found limited use in the synthesis of active pharmaceutical ingredients (APIs)…”
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Kinetic study of Pd-catalyzed hydrogenation of N-benzyl-4-fluoroaniline by Hwang, Hyun Tae, Martinelli, Joseph R., Gounder, Rajamani, Varma, Arvind

“…•The highest conversion with high selectivity to debenzylation was observed for Pd/C.•Debenzylation is promoted by acid buffer while basic buffer suppresses…”
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Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations by Merritt, Jeremy M, Borkar, Indrakant, Buser, Jonas Y, Brewer, Alison Campbell, Campos, Odilon, Fleming, Jeffrey, Hansen, Caoimhe, Humenik, Ashley, Jeffery, Stephen, Kokitkar, Prashant B, Kolis, Stanley P, Forst, Mindy B, Lambertus, Gordon R, Martinelli, Joseph R, McCartan, Ciaran, Moursy, Hossam, Murphy, Donal, Murray, Michael M, O’Donnell, Kevin, O’Sullivan, Rita, Richardson, Gary A, Xia, Han

“…The hazard assessment of a telescoped Miyaura borylation and Suzuki coupling reaction employing bis­(pinacolato)­diboron (BisPin), used in the developmental…”
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Model Guided Development of a Simple Catalytic Method for the Synthesis of Unsymmetrical Stilbenes by Sequential Heck Reactions of Aryl Bromides with Ethylene by Barlow, Helen, Buser, Jonas Y., Glauninger, Hendrik, Luciani, Carla V., Martinelli, Joseph R., Oram, Niall, Thompson‐Van Hook, Nichole, Richardson, Jeffery

“…Stilbenes are important and useful structural moieties, but methods for their preparation typically possess numerous inefficiencies. Presented here is a…”
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Continuous Liquid Vapor Reactions Part 2: Asymmetric Hydroformylation with Rhodium-Bisdiazaphos Catalysts in a Vertical Pipes-in-Series Reactor by Abrams, M. Leigh, Buser, Jonas Y, Calvin, Joel R, Johnson, Martin D, Jones, Bradley R, Lambertus, Gordon, Landis, Clark R, Martinelli, Joseph R, May, Scott A, McFarland, Adam D, Stout, James R

“…Asymmetric hydroformylation (AHF) of 2-vinyl-6-methoxy­naphthalene demonstrates important design characteristics of a vertical pipes-in-series plug flow…”
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Scalable Synthesis of Enantiopure Bis-3,4-diazaphospholane Ligands for Asymmetric Catalysis by Jones, Bradley R, Abrams, M. Leigh, Landis, Clark R, May, Scott A, Campbell, Alison N, Martinelli, Joseph R, Calvin, Joel R

“…An optimized route to enantiopure tetra-carboxylic acid and tetra-carboxamide bis­(diaza­phospholane) ligands that obviates chromatographic purification is…”
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Synthesis of BACE Inhibitor LY2886721. Part II. Isoxazolidines as Precursors to Chiral Aminothiazines, Selective Peptide Coupling, and a Controlled Reactive Crystallization by Hansen, Marvin M, Jarmer, Daniel J, Arslantas, Enver, DeBaillie, Amy C, Frederick, Andrea L, Harding, Molly, Hoard, David W, Hollister, Adrienne, Huber, Dominique, Kolis, Stanley P, Kuehne-Willmore, Jennifer E, Kull, Thomas, Laurila, Michael E, Linder, Ryan J, Martin, Thomas J, Martinelli, Joseph R, McCulley, Michael J, Richey, Rachel N, Starkey, Derek R, Ward, Jeffrey A, Zaborenko, Nikolay, Zweifel, Theo

“…An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a…”
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