Search Results - "Martina, P."

An environment-dependent transcriptional network specifies human microglia identity by Gosselin, David, Skola, Dylan, Coufal, Nicole G., Holtman, Inge R., Schlachetzki, Johannes C. M., Sajti, Eniko, Jaeger, Baptiste N., O’Connor, Carolyn, Fitzpatrick, Conor, Pasillas, Martina P., Pena, Monique, Adair, Amy, Gonda, David D., Levy, Michael L., Ransohoff, Richard M., Gage, Fred H., Glass, Christopher K.

“…Microglia play essential roles in central nervous system (CNS) homeostasis and influence diverse aspects of neuronal function. However, the transcriptional…”
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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Heterogeneity of HSCs in a Mouse Model of NASH by Rosenthal, Sara Brin, Liu, Xiao, Ganguly, Souradipta, Dhar, Debanjan, Pasillas, Martina P., Ricciardelli, Eugenia, Li, Rick Z., Troutman, Ty D., Kisseleva, Tatiana, Glass, Christopher K., Brenner, David A.

“…Background and Aims In clinical and experimental NASH, the origin of the scar‐forming myofibroblast is the HSC. We used foz/foz mice on a Western diet to…”
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It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin by Liebl, Martina P, Hoppe, Thorsten

“…Selective degradation of proteins requires a fine-tuned coordination of the two major proteolytic pathways, the ubiquitin-proteasome system (UPS) and…”
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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity by Sakai, Mashito, Troutman, Ty D., Seidman, Jason S., Ouyang, Zhengyu, Spann, Nathanael J., Abe, Yohei, Ego, Kaori M., Bruni, Cassi M., Deng, Zihou, Schlachetzki, Johannes C.M., Nott, Alexi, Bennett, Hunter, Chang, Jonathan, Vu, BaoChau T., Pasillas, Martina P., Link, Verena M., Texari, Lorane, Heinz, Sven, Thompson, Bonne M., McDonald, Jeffrey G., Geissmann, Frederic, Glass, Christopher K.

“…Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular…”
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Brain cell type-specific enhancer-promoter interactome maps and disease - risk association by Nott, Alexi, Holtman, Inge R, Coufal, Nicole G, Schlachetzki, Johannes C M, Yu, Miao, Hu, Rong, Han, Claudia Z, Pena, Monique, Xiao, Jiayang, Wu, Yin, Keulen, Zahara, Pasillas, Martina P, O'Connor, Carolyn, Nickl, Christian K, Schafer, Simon T, Shen, Zeyang, Rissman, Robert A, Brewer, James B, Gosselin, David, Gonda, David D, Levy, Michael L, Rosenfeld, Michael G, McVicker, Graham, Gage, Fred H, Ren, Bing, Glass, Christopher K

“…Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic…”
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The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice by Janssen, Carola I F, Jansen, Diane, Mutsaers, Martina P C, Dederen, Pieter J W C, Geenen, Bram, Mulder, Monique T, Kiliaan, Amanda J

“…Apolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as…”
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Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling by Minden, Marcus Dühren-von, Übelhart, Rudolf, Schneider, Dunja, Wossning, Thomas, Bach, Martina P., Buchner, Maike, Hofmann, Daniel, Surova, Elena, Follo, Marie, Köhler, Fabian, Wardemann, Hedda, Zirlik, Katja, Veelken, Hendrik, Jumaa, Hassan

“…B-cell receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL) is found not to be dependent on exogenous antigens; instead, signalling may involve the…”
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Medicine and supplement use in infants, children, and adolescents depends on sex, age, and socioeconomic status: results of a German longitudinal population-based cohort study (LIFE Child) by Herzig, Markus, Bertsche, Astrid, Kiess, Wieland, Bertsche, Thilo, Neininger, Martina P.

“…Children and adolescents are exposed to medicines and supplements, but only a few studies have evaluated the actual intake in routine care. Thus, we performed…”
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How do children with focal epilepsies perceive the moment they realize that they are about to have a seizure? A pilot study by Jeschke, Sarah, Charisius, Mathilda, Lange, Sarah, Bertsche, Thilo, Makiello, Phoebe, Neininger, Martina P., Bertsche, Astrid

“…•Some children with focal epilepsies perceive in advance they will have a seizure.•Most children who perceive they will have a seizure undertake measures to…”
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TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4 by Gratuze, Maud, Schlachetzki, Johannes C.M., D’Oliveira Albanus, Ricardo, Jain, Nimansha, Novotny, Brenna, Brase, Logan, Rodriguez, Lea, Mansel, Clayton, Kipnis, Michal, O’Brien, Sydney, Pasillas, Martina P., Lee, Choonghee, Manis, Melissa, Colonna, Marco, Harari, Oscar, Glass, Christopher K., Ulrich, Jason D., Holtzman, David M.

“…In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer’s disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4…”
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Robust LC3B lipidation analysis by precisely adjusting autophagic flux by Liebl, Martina P., Meister, Sarah C., Frey, Lisa, Hendrich, Kristina, Klemmer, Anja, Wohlfart, Bettina, Untucht, Christopher, Nuber, Judith, Pohl, Christian, Lakics, Viktor

“…Autophagic flux can be quantified based on the accumulation of lipidated LC3B in the presence of late-stage autophagy inhibitors. This method has been widely…”
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Two clerodane diterpenes isolated from Polyalthia longifolia leaves: comparative structural features, anti-histaminic and anti-Helicobacter pylori activities by Edmond, Martina P., Mostafa, Nada M., El-Shazly, Mohamed, Singab, Abdel Nasser B.

“…Phytochemical studies of methylene chloride soluble fraction from the 70% aqueous-alcoholic extract of Polyalthia longifolia (leaves) resulted in the isolation…”
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Medication errors in inquiries to the Poison Information Center Erfurt - a systematic analysis by Gollmann, Mandy, Neininger, Martina P., Deters, Michael, Prasa, Dagmar, Bertsche, Thilo

“…Poison Information Centers (PICs) fulfil the legal mandate to provide advice and answer inquiries from healthcare professionals and medical nonprofessionals on…”
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Interviews with children and adolescents with epilepsy or asthma about the situation of their healthy siblings by Charisius, Mathilda, Jeschke, Sarah, Lange, Sarah, Bertsche, Thilo, Ballmann, Manfred, Neininger, Martina P., Bertsche, Astrid

“…Aim Chronic conditions can influence the situation of healthy siblings of affected children. We investigated the opinion of the affected child about the…”
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The impact of a child's inborn error of metabolism: the parents' perspectives on restrictions, discrimination, family planning, and emergency management by Harings, Tanjana, Neininger, Martina P, Eisenhofer, Simone, Thiele, Alena G, Kiess, Wieland, Bertsche, Astrid, Bertsche, Thilo, Beblo, Skadi

“…To investigate the impact of children's inborn error of metabolism (IEMs) on the children's and their parents' lives from the parents' perspective. We focused…”
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NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis by Wang, Gang G, Kamps, Mark P, Cai, Ling, Pasillas, Martina P

“…Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that…”
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Final‐year pharmacy and medical students do not recognise “red flags” in childhood fever by Harsanyi, Jakob, Bertsche, Thilo, Kiess, Wieland, Bertsche, Astrid, Neininger, Martina P.

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Complementary and alternative medicine (CAM) is frequently used by parents for the treatment of functional constipation in children by Nelson, Jana, Mayer, Steffi, Neininger, Martina P., Bertsche, Astrid, Lacher, Martin, Gosemann, Jan‐Hendrik

“…Objectives Complementary and alternative medicine (CAM) has gained increasing attention as a supportive treatment for chronic diseases such as epilepsy,…”
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Nanosulfonated silica incorporated SPEEK/SPVdF-HFP polymer blend membrane for PEM fuel cell application by Martina, P., Gayathri, R., Pugalenthi, M. Raja, Cao, Guozhong, Liu, Chaofeng, Prabhu, M. Ramesh

“…Sulfonated silica particles are admixed with sulfonated poly (ether ether ketone) (SPEEK)/sulfonated poly (vinylidene fluoride-co-hexafluoropropylene)…”
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