Search Results - "Martin Tolstrup"

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial by Rasmussen, Thomas A, Dr, Tolstrup, Martin, PhD, Brinkmann, Christel R, PhD, Olesen, Rikke, PhD, Erikstrup, Christian, MD, Solomon, Ajantha, Winckelmann, Anni, Palmer, Sarah, PhD, Dinarello, Charles, Prof, Buzon, Maria, PhD, Lichterfeld, Mathias, MD, Lewin, Sharon R, Prof, Østergaard, Lars, Prof, Søgaard, Ole S, MD

“…Summary Background Activating the expression of latent virus is an approach that might form part of an HIV cure. We assessed the ability of the histone…”
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The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo by Søgaard, Ole S, Graversen, Mette E, Leth, Steffen, Olesen, Rikke, Brinkmann, Christel R, Nissen, Sara K, Kjaer, Anne Sofie, Schleimann, Mariane H, Denton, Paul W, Hey-Cunningham, William J, Koelsch, Kersten K, Pantaleo, Giuseppe, Krogsgaard, Kim, Sommerfelt, Maja, Fromentin, Remi, Chomont, Nicolas, Rasmussen, Thomas A, Østergaard, Lars, Tolstrup, Martin

“…Pharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a…”
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Inflammation and Platelet Activation After COVID-19 Vaccines - Possible Mechanisms Behind Vaccine-Induced Immune Thrombocytopenia and Thrombosis by Ostrowski, Sisse R, Søgaard, Ole S, Tolstrup, Martin, Stærke, Nina B, Lundgren, Jens, Østergaard, Lars, Hvas, Anne-Mette

“…Introduction of vaccines against COVID-19 has provided the most promising chance to control the world-wide COVID-19 pandemic. However, the adenovirus-vector…”
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The Use of Toll-Like Receptor Agonists in HIV-1 Cure Strategies by Martinsen, Janne Tegder, Gunst, Jesper Damsgaard, Højen, Jesper Falkesgaard, Tolstrup, Martin, Søgaard, Ole Schmeltz

“…Toll-like receptors (TLRs) are a family of pattern recognition receptors and part of the first line of defense against invading microbes. In humans, we know of…”
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Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence Survey Among 17 971 Healthcare and Administrative Personnel at Hospitals, Prehospital Services, and Specialist Practitioners in the Central Denmark Region by Jespersen, Sanne, Mikkelsen, Susan, Greve, Thomas, Kaspersen, Kathrine Agergård, Tolstrup, Martin, Boldsen, Jens Kjærgaard, Redder, Jacob Dvinge, Nielsen, Kent, Abildgaard, Anders Mønsted, Kolstad, Henrik Albert, Østergaard, Lars, Thomsen, Marianne Kragh, Møller, Holger Jon, Erikstrup, Christian

“…Abstract Background The objective of this study was to perform a seroprevalence survey on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among…”
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Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections by Stærke, Nina Breinholt, Reekie, Joanne, Nielsen, Henrik, Benfield, Thomas, Wiese, Lothar, Knudsen, Lene Surland, Iversen, Mette Brouw, Iversen, Kasper, Fogh, Kamille, Bodilsen, Jacob, Juhl, Maria Ruwald, Lindvig, Susan Olaf, Øvrehus, Anne, Madsen, Lone Wulff, Klastrup, Vibeke, Andersen, Sidsel Dahl, Juhl, Anna Karina, Andreasen, Signe Rode, Ostrowski, Sisse Rye, Erikstrup, Christian, Fischer, Thea K., Tolstrup, Martin, Østergaard, Lars, Johansen, Isik Somuncu, Lundgren, Jens, Søgaard, Ole Schmeltz

“…SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk of…”
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Effects of 24-week Toll-like receptor 9 agonist treatment in HIV type 1+ individuals by Vibholm, Line K, Konrad, Christina V, Schleimann, Mariane H, Frattari, Giacomo, Winckelmann, Anni, Klastrup, Vibeke, Jensen, Nanna M, Jensen, Sanne S, Schmidt, Manuel, Wittig, Burghardt, Zuwala, Kaja, Mack, Katharina, Olesen, Rikke, Hua, Stephane, Lichterfeld, Mathias, Østergaard, Lars, Denton, Paul W, Tolstrup, Martin, Søgaard, Ole S

“…DESIGN:This was an exploratory, single-arm clinical trial that tested the immune enhancement effects of 24-weeks of Toll-like receptor 9 (TLR9) agonist…”
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Strategies for enhancing CAR T cell expansion and persistence in HIV infection by Rothemejer, Frederik Holm, Lauritsen, Nanna Pi, Søgaard, Ole Schmeltz, Tolstrup, Martin

“…Chimeric Antigen Receptor (CAR) T cell therapies are tremendously successful in hematological malignancies and show great promise as treatment and curative…”
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Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity by Rosás-Umbert, Miriam, Gunst, Jesper D., Pahus, Marie H., Olesen, Rikke, Schleimann, Mariane, Denton, Paul W., Ramos, Victor, Ward, Adam, Kinloch, Natalie N., Copertino, Dennis C., Escribà, Tuixent, Llano, Anuska, Brumme, Zabrina L., Brad Jones, R., Mothe, Beatriz, Brander, Christian, Fox, Julie, Nussenzweig, Michel C., Fidler, Sarah, Caskey, Marina, Tolstrup, Martin, Søgaard, Ole S.

“…In simian-human immunodeficiency virus (SHIV)-infected non-human primates, broadly neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell…”
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The Potential of Long-Acting, Tissue-Targeted Synthetic Nanotherapy for Delivery of Antiviral Therapy Against HIV Infection by Halling Folkmar Andersen, Anna, Tolstrup, Martin

“…Oral administration of a combination of two or three antiretroviral drugs (cART) has transformed HIV from a life-threatening disease to a manageable infection…”
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SARS-CoV-2 persistence is associated with antigen-specific CD8 T-cell responses by Vibholm, Line K., Nielsen, Stine S.F., Pahus, Marie H., Frattari, Giacomo S., Olesen, Rikke, Andersen, Rebecca, Monrad, Ida, Andersen, Anna H.F., Thomsen, Michelle M., Konrad, Christina V., Andersen, Sidsel D., Højen, Jesper F., Gunst, Jesper D., Østergaard, Lars, Søgaard, Ole S., Schleimann, Mariane H., Tolstrup, Martin

“…Upon SARS-CoV-2 infection, most individuals develop neutralizing antibodies and T-cell immunity. However, some individuals reportedly remain SARS-CoV-2 PCR…”
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Broad activation of latent HIV-1 in vivo by Barton, Kirston, Hiener, Bonnie, Winckelmann, Anni, Rasmussen, Thomas Aagaard, Shao, Wei, Byth, Karen, Lanfear, Robert, Solomon, Ajantha, McMahon, James, Harrington, Sean, Buzon, Maria, Lichterfeld, Mathias, Denton, Paul W., Olesen, Rikke, Østergaard, Lars, Tolstrup, Martin, Lewin, Sharon R., Søgaard, Ole Schmeltz, Palmer, Sarah

“…The ‘shock and kill’ approach to cure human immunodeficiency virus (HIV) includes transcriptional induction of latent HIV-1 proviruses using latency-reversing…”
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HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days--Implications for HIV Remission by Pinkevych, Mykola, Cromer, Deborah, Tolstrup, Martin, Grimm, Andrew J, Cooper, David A, Lewin, Sharon R, Søgaard, Ole S, Rasmussen, Thomas A, Kent, Stephen J, Kelleher, Anthony D, Davenport, Miles P

“…HIV infection can be effectively controlled by anti-retroviral therapy (ART) in most patients. However therapy must be continued for life, because interruption…”
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Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster by Lende, Stine Sofie Frank, Barnkob, Nanna Møller, Hansen, Randi Westh, Bansia, Harsh, Vestergaard, Mike, Rothemejer, Frederik Holm, Worsaae, Anne, Brown, Deijona, Pedersen, Maria Lange, Rahimic, Anna Halling Folkmar, Juhl, Anna Karina, Gjetting, Torben, Østergaard, Lars, Georges, Amédée Des, Vuillard, Laurent-Michel, Schleimann, Mariane Høgsbjerg, Koefoed, Klaus, Tolstrup, Martin

“…Despite development of effective SARS-CoV-2 vaccines, a sub-group of vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases…”
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Nanobody‐mediated complement activation to kill HIV‐infected cells by Pedersen, Maria Lange, Pedersen, Dennis Vestergaard, Winkler, Mikael Becher Lykkegaard, Olesen, Heidi Gytz, Søgaard, Ole Schmeltz, Østergaard, Lars, Laursen, Nick Stub, Rahimic, Anna Halling Folkmar, Tolstrup, Martin

“…The complement system which is part of the innate immune response against invading pathogens represents a powerful mechanism for killing of infected cells…”
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Comparable human reconstitution following Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice by Andersen, Anna Halling Folkmar, Nielsen, Stine Sofie Frank, Olesen, Rikke, Harslund, Jakob Le Fèvre, Søgaard, Ole Schmeltz, Østergaard, Lars, Denton, Paul W, Tolstrup, Martin

“…Humanized mouse models are used extensively in research involving human pathogens and diseases. However, most of these models require preconditioning…”
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Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues by Denton, Paul W, Søgaard, Ole S, Tolstrup, Martin

“…HIV reservoirs persist in infected individuals despite combination antiretroviral therapy and can be identified in secondary lymphoid tissues, in intestinal…”
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SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity by Nielsen, Stine SF, Vibholm, Line K, Monrad, Ida, Olesen, Rikke, Frattari, Giacomo S, Pahus, Marie H, Højen, Jesper F, Gunst, Jesper D, Erikstrup, Christian, Holleufer, Andreas, Hartmann, Rune, Østergaard, Lars, Søgaard, Ole S, Schleimann, Mariane H, Tolstrup, Martin

“…The SARS-CoV-2 pandemic currently prevails worldwide. To understand the immunological signature of SARS-CoV-2 infections and aid the search and evaluation of…”
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A novel SARS-CoV-2 Beta RBD DNA vaccine directly targeted to antigen-presenting cells induces strong humoral and T cell responses by Kuczkowska, Katarzyna, Bjerkan, Louise, Stubsrud, Elisabeth, Husbyn, Hannah Cuthbertson, Chellappa, Stalin, Hauge, Anette, Skarshaug, Renate, Torgersen, Maria Lyngaas, Heim, Joel Benjamin, Jørgensen, Marthe Jøntvedt, Wold, Christian Winther, Schleimann, Mariane Høgsbjerg, Tolstrup, Martin, Granum, Stine, Fredriksen, Agnete Brunsvik, Pedersen, Mikkel Wandahl, Norheim, Gunnstein

“…Throughout the COVID-19 pandemic, several variants of concern (VoC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have evolved, affecting…”
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Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial by Leth, Steffen, Dr, Schleimann, Mariane H, PhD, Nissen, Sara K, MS, Højen, Jesper F, MD, Olesen, Rikke, PhD, Graversen, Mette E, MD, Jørgensen, Sofie, BSs, Kjær, Anne Sofie, MD, Denton, Paul W, PhD, Mørk, Alejandra, PhD, Sommerfelt, Maja A, PhD, Krogsgaard, Kim, DMSc, Østergaard, Lars, Prof, Rasmussen, Thomas A, PhD, Tolstrup, Martin, PhD, Søgaard, Ole Schmeltz, Dr

“…Summary Background Immune priming before reversal of latency might be a component of a functional HIV cure. To assess this concept, we assessed if therapeutic…”
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