Search Results - "Martin Soberón, Maria Cruz"

Immunotherapy maintenance therapy for advanced urothelial carcinoma (aUC): a comprehensive review by Carril-Ajuria, Lucia, Martin-Soberón, Maria Cruz, de Velasco, Guillermo, Agarwal, Neeraj, Castellano, Daniel

“…Immunotherapy has revolutionized the systemic treatment of solid tumors, including advanced urothelial carcinoma (aUC), providing durable responses with a…”
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Trotabresib (CC-90010) in combination with adjuvant temozolomide or concomitant temozolomide plus radiotherapy in patients with newly diagnosed glioblastoma by Vieito, Maria, Simonelli, Matteo, de Vos, Filip, Moreno, Victor, Geurts, Marjolein, Lorenzi, Elena, Macchini, Marina, van den Bent, Martin J, Del Conte, Gianluca, de Jonge, Maja, Martín-Soberón, Maria Cruz, Amoroso, Barbara, Sanchez-Perez, Tania, Zuraek, Marlene, Hanna, Bishoy, Aronchik, Ida, Filvaroff, Ellen, Chang, Henry, Mendez, Cristina, Arias Parro, Marina, Wei, Xin, Nikolova, Zariana, Sepulveda, Juan Manuel

“…Standard-of-care treatment for newly diagnosed glioblastoma (ndGBM), consisting of surgery followed by radiotherapy (RT) and temozolomide (TMZ), has improved…”
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Immune checkpoint inhibitors plus tyrosine kinase inhibitors combination in the first-line setting of metastatic clear cell renal cell carcinoma: A meta-analysis of randomized clinical trials by Martin Soberón, Maria Cruz, Carretero-González, Alberto, de Velasco, Guillermo, Carril, Lucia, Castellano, Daniel

“…Abstract only 704 Background: ICIs + TKIs have shown to improve outcomes in treatment-naïve metastatic clear-cell renal cell carcinoma (ccRCC). We aimed to…”
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Dynamic profiling in patients with metastatic clear cell renal cell carcinoma (mRCC) undergoing first-line treatment with cabozantinib: A sub-exploratory analysis from CABOPRE trial by Álvarez, Pablo, Dueñas, Marta, Alonso Gordoa, Teresa, Rodriguez-Moreno, Juan Francisco, Carretero-González, Alberto, Ruiz-Granados, Álvaro, Martin Soberón, Maria Cruz, Sotelo, Marta, Esteban Villarrubia, Jorge, Paramio, Jesus, Castellano, Daniel, de Velasco, Guillermo

“…474 Background: RCC is a heterogeneous disease with variable responses to systemic therapy. Tumor microenvironment (TME) and mi-RNA expression has been…”
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Impact of age in advanced renal cell carcinoma treated with immune checkpoint inhibitors by Carretero-González, Alberto, Lora, David, Carril Ajuria, Lucía, Martin Soberón, Maria Cruz, Castellano, Daniel, de Velasco, Guillermo

“…Abstract only 702 Background: Immune checkpoint inhibitors (ICIs) are beneficial in a subset of metastatic renal cell carcinoma (mRCC) patients. Elderly…”
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Atezolizumab + intravesical BCG (Bacillus Calmette-Guerin) in high-risk non-muscle invasive bladder cancer (NMIBC) patients: Institutional clinical and translational study (BladderGATE) by Castellano, Daniel, de Velasco, Guillermo, Martin Soberón, Maria Cruz, Carretero-González, Alberto, Dueñas, Marta, Paramio, Jesus, De La Rosa, Federico, Sanz, Juan Luis, Guerrero, Félix

“…Abstract only TPS598 Background: Intravesical Bacillus Calmette-Guerin (BCG) induction + BCG maintenance after transurethral resection (TURBT) is the current…”
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Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (mCRPC): A post-hoc analysis of two randomized clinical trials by de Velasco, Guillermo, Lora, David, Carretero-Gonzalez, Alberto, Martin Soberón, Maria Cruz, Sepulveda Sanchez, Juan Manuel Manuel, Lorente, David, Castellano, Daniel E.

“…Abstract only 6617 Background: Retrospective database studies have suggested that statins and vitamin D have a positive impact on prostate cancer survival and…”
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Efficacy of first-line combination therapy in metastatic renal cell carcinoma (mRCC) patients (pts) with poor performance status (PS) by Carril, Lucia, Colomba, Emeline, Romero-Ferreiro, Carmen, Cerbone, Luigi, Ratta, Raffaele, Barthélémy, Philippe, Vindry, Clarisse, Cherifi, Francois, Boughalem, Elouen, Linassier, Claude, Fornarini, Giuseppe, Gross-Goupil, Marine, Saldana, Carolina, Martin Soberón, Maria Cruz, de Velasco, Guillermo, Pernaut, Cristina, Alves Costa Silva, Carolina, Flippot, Ronan, Escudier, Bernard, Albiges, Laurence

“…Abstract only 320 Background: Immune checkpoint combination therapy (ICI-combo) is the new standard of care for mRCC in first-line setting. However, pts with…”
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Inflammatory markers to predict prognosis in renal cell carcinoma (RCC) patients treated with immune checkpoint inhibitors (ICIs) by Carril, Lucia, Gomez De Liano Lista, Alfonso, Pozas, Javier, Alonso Gordoa, Teresa, Bernardini, Alejandra, Carretero-González, Alberto, Martin Soberón, Maria Cruz, Sepulveda Sanchez, Juan Manuel Manuel, Paramio, Jesus, Castellano, Daniel, De Velasco, Guillermo

“…Abstract only 757 Background: Immune checkpoint inhibitors have increased survival in mRCC across all risk groups. In this new treatment paradigm, inflammatory…”
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Elderly glioblastoma patients: Survival analysis according adjuvant therapy and tumor molecular analysis by Vaz, Maria Angeles, Ceballos Lenza, Isaac, Berron, Sonia Del Barco, Martin Soberón, Maria Cruz, Gallego Rubio, Oscar, Gironés Sarrió, Regina, Quintanar Verduguez, Maria Teresa, Sarabia, Rosario, Benavides, Manuel, Ivars Rubio, Alejandra, Fernandez, Isaura, Gutierrez Toribio, María, Tuñón Alvarez, Maria Teresa, Cunquero Tomas, Alberto Jacobo, Moya Horno, Irene, Sepulveda Sánchez, José Manuel, Peralta Muñoz, Sergio, De Las Peñas Bataller, Ramon

“…Abstract only e14046 Background: Glioblastoma (GBM) grade IV represents the most frequent and aggressive primary brain tumor. Despite complete surgical…”
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Study of tumor infiltrating immune CELLS and vasculature in human gliomas: Differences in IDH1/2 mutant versus IDH1/2WT tumors by Martin Soberón, Maria Cruz, Sepulveda Sanchez, Juan Manuel Manuel, Gargini, Ricardo, Segura, Berta, Gutierrez, Jacquelin, Ruano, Yolanda, Cantero, Diana, Hernandez-Lain, Aurelio, Sanchez-Gomez, Pilar, Perez-Núñez, Angel, Jimenez Roldan, Luis, Marín, Patricia, Castellano, Daniel E., De Velasco, Guillermo, Cejalvo, Teresa

“…Abstract only 2030 Background: Gliomas harboring mutations in IDH1/2 show a higher overall survival time than “wild type” (wt) tumors. Although the clinical…”
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Immune Profiling of Gliomas Reveals a Connection with IDH1/2 Mutations, Tau Function and the Vascular Phenotype by Cejalvo, Teresa, Gargini, Ricardo, Segura-Collar, Berta, Mata-Martínez, Pablo, Herranz, Beatriz, Cantero, Diana, Ruano, Yolanda, García-Pérez, Daniel, Pérez-Núñez, Ángel, Ramos, Ana, Hernández-Laín, Aurelio, Martín-Soberón, María Cruz, Sánchez-Gómez, Pilar, Sepúlveda-Sánchez, Juan M.

“…Background: Gliomas remain refractory to all attempted treatments, including those using immune checkpoint inhibitors. The characterization of the tumor…”
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Phase II Trial of Palbociclib in Recurrent Retinoblastoma-Positive Anaplastic Oligodendroglioma: A Study from the Spanish Group for Research in Neuro-Oncology (GEINO) by Sepúlveda-Sánchez, Juan Manuel, Gil-Gil, Miguel, Alonso-García, Miriam, Vaz Salgado, María Ángeles, Vicente, Elena, Mesía Barroso, Carlos, Rodríguez Sánchez, Ángel, Durán, Gema, De Las Peñas, Ramón, Muñoz-Langa, José, Velasco, Guillermo, Hernández-Laín, Aurelio, Hilario, Amaya, Navarro Martín, Miguel, Benavides, Manuel, Oleaga, Laura, Cantero Montenegro, Diana, Ruano, Yolanda, Sánchez-Gómez, Pilar, Martín-Soberón, María Cruz, Morales-Llombart, Robert, Pachón, Vanessa, Pineda, Estela

“…Background The cell cycle checkpoint G1/S, dependent on cyclin-dependent kinase (CDK) 4 amplification/overexpression and retinoblastoma phosphorylation, is…”
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Genomic Landscape of Vinflunine Response in Metastatic Urothelial Cancer by Bernardini, Alejandra, Dueñas, Marta, Martín-Soberon, María Cruz, Rubio, Carolina, Suarez-Cabrera, Cristian, Ruiz-Palomares, Raquel, Munera-Maravilla, Ester, Lázaro, Sara, Lodewijk, Iris, Rueda, Daniel, Gómez-Sánchez, David, Alonso-Gordoa, Teresa, Puente, Javier, Pinto, Álvaro, González-Peramato, Pilar, Aguado, Carlos, Herrera, Mercedes, López, Flora, Martinez, Victor M G, Morales, Lucía, Castellano, Daniel, Paramio, Jesús M, de Velasco, Guillermo

“…Metastatic urothelial carcinoma (mUC) remains an incurable disease with limited treatment options after platinum-based chemotherapy and immune checkpoint…”
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CTNI-21. TROTABRESIB (CC-90010) IN COMBINATION WITH CONCOMITANT TEMOZOLOMIDE PLUS RADIOTHERAPY AND ADJUVANT TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA: UPDATED RESULTS FROM A PHASE 1B/2 STUDY by Vieito, Maria, Sepulveda, Juan Manuel, Moreno, Victor, de Vos, Filip, Geurts, Marjolein, Lorenzi, Elena, Macchini, Marina, van den Bent, Martin, Del Conte, Gianluca, Martín-Soberón, Maria Cruz, Brandal, Petter, Garcia, Maria Martinez, Amoroso, Barbara, Sanchez-Perez, Tania, Zuraek, Marlene, Hanna, Bishoy, Filvaroff, Ellen, Chang, Henry, Parro, Marina Arias, Wei, Xin, Liu, Yu, Nikolova, Zariana, Simonelli, Matteo

“…Trotabresib, a novel bromodomain and extraterminal protein inhibitor, has demonstrated antitumor activity and blood–brain barrier penetration in patients with…”
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Molecular Targeted Therapy in Oncology Focusing on DNA Repair Mechanisms by Garzón-Hernández, Carlos, Ramírez-Merino, Natalia, Soberon, María Cruz Martín

“…DNA repair mechanisms are essential for maintaining cellular homeostasis. Malfunction of these repair mechanisms leads to cellular DNA mutations, carcinogenic…”
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