Search Results - "Martin Köhler"

Hydrophobic Moieties Bestow Fast-Folding and Hyperstability on Collagen Triple Helices by Egli, Jasmine, Siebler, Christiane, Köhler, Martin, Zenobi, Renato, Wennemers, Helma

“…Trans amide bonds and fast cis–trans isomerization of Xaa-Pro bonds are crucial for the stability and folding rate of collagen, the most abundant protein in…”
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Microfluidic Platform for Multimodal Analysis of Enzyme Secretion in Nanoliter Droplet Arrays by Haidas, Dominik, Bachler, Simon, Köhler, Martin, Blank, Lars M, Zenobi, Renato, Dittrich, Petra S

“…High-throughput screening of cell-secreted proteins is essential for various biotechnological applications. In this article, we show a microfluidic approach to…”
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A Lateral Salt Bridge for the Specific Assembly of an ABC-Type Collagen Heterotrimer by Hentzen, Nina B, Islami, Valdrin, Köhler, Martin, Zenobi, Renato, Wennemers, Helma

“…Nature uses salt bridges to control the folding and stability of many proteins, including collagen, the key structural protein in mammals. Here, we present an…”
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Advances in simulating atmospheric variability with the ECMWF model: From synoptic to decadal time‐scales by Bechtold, Peter, Köhler, Martin, Jung, Thomas, Doblas‐Reyes, Francisco, Leutbecher, Martin, Rodwell, Mark J., Vitart, Frederic, Balsamo, Gianpaolo

“…Advances in simulating atmospheric variability with the ECMWF model are presented that stem from revisions of the convection and diffusion parametrizations…”
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B-Raf activation loop phosphorylation revisited by Köhler, Martin, Brummer, Tilman

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Protein carbamylation is a hallmark of aging by Gorisse, Laëtitia, Pietrement, Christine, Vuiblet, Vincent, Schmelzer, Christian E. H., Köhler, Martin, Duca, Laurent, Debelle, Laurent, Fornès, Paul, Jaisson, Stéphane, Gillery, Philippe

“…Aging is a progressive process determined by genetic and acquired factors. Among the latter are the chemical reactions referred to as nonenzymatic…”
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Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells by Moede, Tilo, Leibiger, Barbara, Vaca Sanchez, Pilar, Daré, Elisabetta, Köhler, Martin, Muhandiramlage, Thusitha P., Leibiger, Ingo B., Berggren, Per-Olof

“…The secretion of glucagon by pancreatic alpha cells is regulated by a number of external and intrinsic factors. While the electrophysiological processes…”
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Donor Islet Endothelial Cells Participate in Formation of Functional Vessels Within Pancreatic Islet Grafts by Nyqvist, Daniel, Köhler, Martin, Wahlstedt, Helene, Berggren, Per-Olof

“…Donor Islet Endothelial Cells Participate in Formation of Functional Vessels Within Pancreatic Islet Grafts Daniel Nyqvist 1 , Martin Köhler 1 , Helene…”
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Temperature-controlled electrospray ionization mass spectrometry as a tool to study collagen homo- and heterotrimers by Köhler, Martin, Marchand, Adrien, Hentzen, Nina B, Egli, Jasmine, Begley, Alina I, Wennemers, Helma, Zenobi, Renato

“…Collagen model peptides are useful for understanding the assembly and structure of collagen triple helices. The design of self-assembling heterotrimeric…”
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3D‐Printed Biohybrid Microstructures Enable Transplantation and Vascularization of Microtissues in the Anterior Chamber of the Eye by Kavand, Hanie, Visa, Montse, Köhler, Martin, Wijngaart, Wouter, Berggren, Per‐Olof, Herland, Anna

“…Hybridizing biological cells with man‐made sensors enable the detection of a wide range of weak physiological responses with high specificity. The anterior…”
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Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody by Perez, Camilo, Köhler, Martin, Janser, Daniel, Pardon, Els, Steyaert, Jan, Zenobi, Renato, Locher, Kaspar P.

“…PglK is an ABC transporter that flips a lipid-linked oligosaccharide (LLO) that serves as a donor in protein N-glycosylation. Previous structures revealed two…”
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Current developments in immunotherapy in the treatment of multiple myeloma by Köhler, Martin, Greil, Christine, Hudecek, Michael, Lonial, Sagar, Raje, Noopur, Wäsch, Ralph, Engelhardt, Monika

“…Multiple myeloma (MM) is the second most common hematologic malignancy and represents approximately 10% of all hematological neoplasms. Standard therapy…”
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Comparison of river basin hydrometeorology in ERA-Interim and ERA-40 reanalyses with observations by Betts, Alan K., Köhler, Martin, Zhang, Yuanchong

“…The changes between the ERA‐40 and ERA‐Interim in the seasonal cycle of primarily temperature, precipitation and evaporation, the surface radiation budget, and…”
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Debate: Accommodating the prudence principle in EPSAS design by Brixner, Helge C., Köhler, Martin

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Blocking Ca2+ Channel β3 Subunit Reverses Diabetes by Lee, Kayoung, Kim, Jaeyoon, Köhler, Martin, Yu, Jia, Shi, Yue, Yang, Shao-Nian, Ryu, Sung Ho, Berggren, Per-Olof

“…Voltage-gated Ca2+ channels (Cav) are essential for pancreatic beta cell function as they mediate Ca2+ influx, which leads to insulin exocytosis. The β3…”
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Survey on Methods for Analysis and Conservation of Hydrated Lime Particles Sampled in Flue Gas Cleaning Systems by Köhler, Martin, Ohle, Andrea, Bernhardt, Daniel, Gebauer, Kathrin, Beckmann, Michael, Kaiser, Marie, Spiegel, Wolfgang

“…In terms of analyzing and modeling conditioned dry absorption, an unbiased view on the injected hydrated lime particles is needed. Multiple investigations on…”
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Modelling of Acid Mine Drainage in Open Pit Lakes Using Sentinel-2 Time-Series: A Case Study from Lusatia, Germany by Delira Hanelli, Andreas Barth, Gerald Volkmer, Martin Köhler

“…Strong acid mine drainage (AMD) processes in the flooded, formerly open pits in the Lusatia area present an enormous environmental challenge for the…”
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Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry by Köhler, Martin, Neff, Christoph, Perez, Camilo, Brunner, Cyrill, Pardon, Els, Steyaert, Jan, Schneider, Gisbert, Locher, Kaspar P, Zenobi, Renato

“…The application of nanobodies as binding partners for structure stabilization in protein X-ray crystallography is taking an increasingly important role in…”
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Islet Transplantation to the Anterior Chamber of the Eye—A Future Treatment Option for Insulin-Deficient Type-2 Diabetics? A Case Report from a Nonhuman Type-2 Diabetic Primate by Tun, Sai Bo Bo, Chua, Minni, Hasan, Riasat, Köhler, Martin, Zheng, Xiaofeng, Ali, Yusuf, Abdulreda, Midhat H., Juntti-Berggren, Lisa, Barathi, Veluchamy A., Berggren, Per-Olof

“…Replacement of the insulin-secreting beta cells through transplantation of pancreatic islets to the liver is a promising treatment for type-1 diabetes…”
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SCIENTIFIC CHALLENGES OF CONVECTIVE-SCALE NUMERICAL WEATHER PREDICTION by Yano, Jun-Ichi, Ziemiański, Michał Z., Cullen, Mike, Termonia, Piet, Onvlee, Jeanette, Bengtsson, Lisa, Carrassi, Alberto, Davy, Richard, Deluca, Anna, Gray, Suzanne L., Homar, Víctor, Köhler, Martin, Krichak, Simon, Michaelides, Silas, Phillips, Vaughan T. J., Soares, Pedro M. M., Wyszogrodzki, Andrzej A.

“…After extensive efforts over the course of a decade, convective-scale weather forecasts with horizontal grid spacings of 1–5 km are now operational at national…”
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