Search Results - "Martin Hernando, José I."

Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors by Ontoria, Jesus M, Rydberg, Edwin H, Di Marco, Stefania, Tomei, Licia, Attenni, Barbara, Malancona, Savina, Martin Hernando, José I, Gennari, Nadia, Koch, Uwe, Narjes, Frank, Rowley, Michael, Summa, Vincenzo, Carroll, Steve S, Olsen, David B, De Francesco, Raffaele, Altamura, Sergio, Migliaccio, Giovanni, Carfì, Andrea

“…The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian…”
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Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates by Malancona, Savina, Donghi, Monica, Ferrara, Marco, Martin Hernando, Josè I., Pompei, Marco, Pesci, Silvia, Ontoria, Jesus M., Koch, Uwe, Rowley, Michael, Summa, Vincenzo

“…Chronic hepatitis C virus (HCV) infections are a significant medical problem worldwide. The NS5B Polymerase of HCV plays a central role in virus replication…”
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Improved modular synthesis of thieno[3,2- b]pyrroles and thieno[2,3- b]pyrroles by Malancona, Savina, Hernando, Josè I. Martin, Attenni, Barbara, Ontoria, Jesus M., Narjes, Frank

“…A convenient synthesis of densely functionalized thieno[3,2- b]pyrroles and thieno[2,3-b]pyrroles is described. A convenient modular synthesis for the…”
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Total synthesis of (±)-stemonamide and (±)-isostemonamide by Kende, Andrew S, Martin Hernando, Jose I, Milbank, Jared B.J

“…Two different approaches to the alkaloids stemonamide and isostemonamide using N-acyliminium chemistry are described. The approach using an aldol…”
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First Total Synthesis of (±)-Stemonamide and (±)-Isostemonamide by Kende, Andrew S, Martin Hernando, Jose I, Milbank, Jared B. J

“…The total synthesis of the tetracyclic alkaloids stemonamide (1) and isostemonamide (2) is presented. The key step is the reaction between a silyloxyfuran and…”
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Identification of thieno[3,2- b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase by Ontoria, Jesus M., Martìn Hernando, Jose I., Malancona, Savina, Attenni, Barbara, Stansfield, Ian, Conte, Immacolata, Ercolani, Caterina, Habermann, Jörg, Ponzi, Simona, Di Filippo, Marcello, Koch, Uwe, Rowley, Michael, Narjes, Frank

“…Thieno[3,2- b]pyrroles are a novel class of allosteric inhibitors of HCV NS5B RNA-dependent RNA polymerase which show potent affinity for the NS5B enzyme…”
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A practical access into conveniently functionalized, homochiral C-ring system of taxuyunnanine C by Candela Lena, José I., del R. Rico Ferreira, Maria, Martı́n Hernando, José I., Arseniyadis, Siméon

“…The preparation of a homochiral 7-nor taxoid C-ring framework, to be used in an A+C approach for the synthesis of low oxygenation pattern taxoids with an…”
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Identification and Biological Evaluation of a Series of 1 H -Benzo[ de ]isoquinoline-1,3(2 H )-diones as Hepatitis C Virus NS5B Polymerase Inhibitors by Ontoria, Jesus M., Rydberg, Edwin H., Di Marco, Stefania, Tomei, Licia, Attenni, Barbara, Malancona, Savina, Martin Hernando, José I., Gennari, Nadia, Koch, Uwe, Narjes, Frank, Rowley, Michael, Summa, Vincenzo, Carroll, Steve S., Olsen, David B., De Francesco, Raffaele, Altamura, Sergio, Migliaccio, Giovanni, Carfì, Andrea

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The aldol–annulation–fragmentation strategy toward the taxoid diterpene framework revisited. Instructive failures in the chemistry of medium ring containing systems by Hamon, Sylvain, del Rosario Rico Ferreira, María, Quílez del Moral, José, Martín Hernando, José I., Candela Lena, José I., Birlirakis, Nicolas, Toupet, Loı¨c, Arseniyadis, Siméon

“…Central intermediate 5 for the taxoid diterpene framework, prepared by the aldol–annulation sequence, permitted the construction of A-secotaxane frameworks…”
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