Search Results - "Martin, Stephen F."

Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds by Sunderhaus, James D., Martin, Stephen F.

“…The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic…”
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Recent applications of imines as key intermediates in the synthesis of alkaloids and novel nitrogen heterocycles by Martin, Stephen F.

“…One of the major challenges in contemporary synthetic organic chemistry is the design and development of new tactics and strategies and their application to…”
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Differentially Substituted Phosphines via Decarbonylation of Acylphosphines by Yu, Rongrong, Chen, Xingyu, Martin, Stephen F, Wang, Zhiqian

“…A new route to phosphines was developed by a method that features a “pre-join and transform” process that proceeds via acylphosphine intermediates that may be…”
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Bifunctional Catalyst Promotes Highly Enantioselective Bromolactonizations To Generate Stereogenic C–Br Bonds by Paull, Daniel H, Fang, Chao, Donald, James R, Pansick, Andrew D, Martin, Stephen F

“…A novel bifunctional catalyst derived from BINOL has been developed that promotes the highly enantioselective bromolactonizations of a number of structurally…”
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Enantioselective Total Synthesis of (−)-Citrinadin A and Revision of Its Stereochemical Structure by Bian, Zhiguo, Marvin, Christopher C, Martin, Stephen F

“…The first enantioselective total synthesis of (−)-citrinadin A has been accomplished in 20 steps from commercially available materials via an approach that…”
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Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease by Yi, Bitna, Sahn, James J., Ardestani, Pooneh Memar, Evans, Andrew K., Scott, Luisa L., Chan, Jessica Z., Iyer, Sangeetha, Crisp, Ashley, Zuniga, Gabriella, Pierce, Jonathan T., Martin, Stephen F., Shamloo, Mehrdad

“…Accumulating evidence suggests that modulating the sigma 2 receptor (Sig2R) can provide beneficial effects for neurodegenerative diseases. Herein, we report…”
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Correlating structure and energetics in protein-ligand interactions: paradigms and paradoxes by Martin, Stephen F, Clements, John H

“…Predicting protein-binding affinities of small molecules, even closely related ones, is a formidable challenge in biomolecular recognition and medicinal…”
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Synthesis of (+)-Disparlure via Enantioselective Iodolactonization by Klosowski, Daniel W, Martin, Stephen F

“…The BINOL-amidine organic catalyst 1 was previously shown to promote highly efficient enantioselective halolactonization reactions of olefinic acids. As part…”
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Total Synthesis of Cribrostatin 6 by Knueppel, Daniel, Martin, Stephen F

“…Fast and furious: Cribrostatin 6, an antimicrobial and antineoplastic agent, was the target of a total synthesis where the longest linear sequence was only…”
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Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice by Sahn, James J, Mejia, Galo L, Ray, Pradipta R, Martin, Stephen F, Price, Theodore J

“…Neuropathic pain is an important medical problem with few effective treatments. The sigma 1 receptor (σ1R) is known to be a potential target for neuropathic…”
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Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification by Sahn, James J, Granger, Brett A, Martin, Stephen F

“…A strategy for generating diverse collections of small molecules has been developed that features a multicomponent assembly process (MCAP) to efficiently…”
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σ2R/TMEM97 in retinal ganglion cell degeneration by Wang, Hua, Peng, Zhiyou, Li, Yiwen, Sahn, James J., Hodges, Timothy R., Chou, Tsung-Han, Liu, Qiong, Zhou, Xuezhi, Jiao, Shuliang, Porciatti, Vittorio, Liebl, Daniel J., Martin, Stephen F., Wen, Rong

“…The sigma 2 receptor (σ 2 R) was recently identified as an endoplasmic reticulum (ER) membrane protein known as transmembrane protein 97 (TMEM97). Studies have…”
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Enantioselective Halolactonization Reactions using BINOL-Derived Bifunctional Catalysts: Methodology, Diversification, and Applications by Klosowski, Daniel W, Hethcox, J. Caleb, Paull, Daniel H, Fang, Chao, Donald, James R, Shugrue, Christopher R, Pansick, Andrew D, Martin, Stephen F

“…A general protocol is described for inducing enantioselective halolactonizations of unsaturated carboxylic acids using novel bifunctional organic catalysts…”
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Enantioselective Iodolactonization of Disubstituted Olefinic Acids Using a Bifunctional Catalyst by Fang, Chao, Paull, Daniel H, Hethcox, J. Caleb, Shugrue, Christopher R, Martin, Stephen F

“…The enantioselective iodolactonizations of a series of diversely substituted olefinic carboxylic acids are promoted by a BINOL-derived, bifunctional catalyst…”
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Carbonylative Cross-Coupling of ortho-Disubstituted Aryl Iodides. Convenient Synthesis of Sterically Hindered Aryl Ketones by O’Keefe, B. Michael, Simmons, Nicholas, Martin, Stephen F

“…A mild and general protocol for the carbonylative cross-coupling of sterically hindered ortho-disubstituted aryl iodides is reported. Carbonylative…”
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Synthesis of (±)-Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total Synthesis by Granger, Brett A, Jewett, Ivan T, Butler, Jeffrey D, Hua, Bruce, Knezevic, Claire E, Parkinson, Elizabeth I, Hergenrother, Paul J, Martin, Stephen F

“…Actinophyllic acid is a biologically active indole alkaloid with a unique structural framework that incorporates five contiguous stereocenters. A total…”
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Synthesis of diverse heterocyclic scaffolds via tandem additions to imine derivatives and ring-forming reactions by Sunderhaus, James D., Dockendorff, Chris, Martin, Stephen F.

“…A novel strategy has been developed for the efficient syntheses of diverse arrays of heterocyclic compounds. The key elements of the approach comprise a…”
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Evolution of the Vinylogous Mannich Reaction as a Key Construction for Alkaloid Synthesis by Martin, Stephen F

“…The vinylogous Mannich reaction is rapidly emerging as an important process for the construction of derivatives of δ-aminocarbonyl compounds. Because the…”
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Multicomponent Assembly Strategies for the Synthesis of Diverse Tetrahydroisoquinoline Scaffolds by Granger, Brett A, Kaneda, Kyosuke, Martin, Stephen F

“…Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a…”
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General Strategy for the Syntheses of Corynanthe, Tacaman, and Oxindole Alkaloids by Deiters, Alexander, Pettersson, Martin, Martin, Stephen F

“…We report herein the total synthesis of the corynanthe alkaloid dihydrocorynantheol and the formal syntheses of the indole alkaloids tacamonine,…”
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