Search Results - "Martin, Rowena E"

Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes by Bushell, Ellen, Gomes, Ana Rita, Sanderson, Theo, Anar, Burcu, Girling, Gareth, Herd, Colin, Metcalf, Tom, Modrzynska, Katarzyna, Schwach, Frank, Martin, Rowena E., Mather, Michael W., McFadden, Geoffrey I., Parts, Leopold, Rutledge, Gavin G., Vaidya, Akhil B., Wengelnik, Kai, Rayner, Julian C., Billker, Oliver

“…The genomes of malaria parasites contain many genes of unknown function. To assist drug development through the identification of essential genes and pathways,…”
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Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies by Veiga, M. Isabel, Dhingra, Satish K., Henrich, Philipp P., Straimer, Judith, Gnädig, Nina, Uhlemann, Anne-Catrin, Martin, Rowena E., Lehane, Adele M., Fidock, David A.

“…Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies (ACTs), is threatened by the spread of drug resistance in Plasmodium…”
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The natural function of the malaria parasite’s chloroquine resistance transporter by Shafik, Sarah H., Cobbold, Simon A., Barkat, Kawthar, Richards, Sashika N., Lancaster, Nicole S., Llinás, Manuel, Hogg, Simon J., Summers, Robert L., McConville, Malcolm J., Martin, Rowena E.

“…The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor to multidrug resistance and is also essential for the survival of the…”
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Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter by Martin, Rowena E, Marchetti, Rosa V, Cowan, Anna I, Howitt, Susan M, Bröer, Stefan, Kirk, Kiaran

“…The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria parasites has been a disaster for world health. Resistance is conferred by…”
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Identifying the major lactate transporter of Toxoplasma gondii tachyzoites by Zeng, Joy M., Hapuarachchi, Sanduni V., Shafik, Sarah H., Martin, Rowena E., Kirk, Kiaran, van Dooren, Giel G., Lehane, Adele M.

“…Toxoplasma gondii and Plasmodium falciparum parasites both extrude l -lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, Pf…”
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The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens by Hapuarachchi, Sanduni V, Cobbold, Simon A, Shafik, Sarah H, Dennis, Adelaide S M, McConville, Malcolm J, Martin, Rowena E, Kirk, Kiaran, Lehane, Adele M

“…In this study the 'Malaria Box' chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH…”
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Characterization of a Dopamine Transporter and Its Splice Variant Reveals Novel Features of Dopaminergic Regulation in the Honey Bee by Zhang, Vicky, Kucharski, Robert, Landers, Courtney, Richards, Sashika N., Bröer, Stefan, Martin, Rowena E., Maleszka, Ryszard

“…Dopamine is an important neuromodulator involved in reward-processing, movement control, motivational responses, and other aspects of behavior in most animals…”
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Inferring a complete genotype-phenotype map from a small number of measured phenotypes by Sailer, Zachary R, Shafik, Sarah H, Summers, Robert L, Joule, Alex, Patterson-Robert, Alice, Martin, Rowena E, Harms, Michael J, Mac Gabhann, Feilim, Morozov, Alexandre V

“…Understanding evolution requires detailed knowledge of genotype-phenotype maps; however, it can be a herculean task to measure every phenotype in a…”
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The transportome of the malaria parasite by Martin, Rowena E.

“…ABSTRACT Membrane transport proteins, also known as transporters, control the movement of ions, nutrients, metabolites, and waste products across the membranes…”
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Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite’s chloroquine resistance transporter by Summers, Robert L, Dave, Anurag, Dolstra, Tegan J, Bellanca, Sebastiano, Marchetti, Rosa V, Nash, Megan N, Richards, Sashika N, Goh, Valerie, Schenk, Robyn L, Stein, Wilfred D, Kirk, Kiaran, Sanchez, Cecilia P, Lanzer, Michael, Martin, Rowena E

“…Mutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium…”
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Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter by Richards, Sashika N, Nash, Megan N, Baker, Eileen S, Webster, Michael W, Lehane, Adele M, Shafik, Sarah H, Martin, Rowena E

“…Mutations in the Plasmodium falciparum 'chloroquine resistance transporter' (PfCRT) confer resistance to chloroquine (CQ) and related antimalarials by enabling…”
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Quinoline Antimalarials Containing a Dibemethin Group Are Active against Chloroquinone-Resistant Plasmodium falciparum and Inhibit Chloroquine Transport via the P. falciparum Chloroquine-Resistance Transporter (PfCRT) by Zishiri, Vincent K, Joshi, Mukesh C, Hunter, Roger, Chibale, Kelly, Smith, Peter J, Summers, Robert L, Martin, Rowena E, Egan, Timothy J

“…A series of 4-amino-7-chloroquinolines with dibenzylmethylamine (dibemethin) side chains were shown to inhibit synthetic hemozoin formation. These compounds…”
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Optimization of 4‑Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure–Activity Relationships, in Vivo Studies, and Preliminary Toxicity Profiling by Gemma, Sandra, Camodeca, Caterina, Sanna Coccone, Salvatore, Joshi, Bhupendra P, Bernetti, Matteo, Moretti, Vittoria, Brogi, Simone, Bonache de Marcos, Maria Cruz, Savini, Luisa, Taramelli, Donatella, Basilico, Nicoletta, Parapini, Silvia, Rottmann, Matthias, Brun, Reto, Lamponi, Stefania, Caccia, Silvio, Guiso, Giovanna, Summers, Robert L, E. Martin, Rowena, Saponara, Simona, Gorelli, Beatrice, Novellino, Ettore, Campiani, Giuseppe, Butini, Stefania

“…Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of…”
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Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance by Bray, Patrick G., Martin, Rowena E., Tilley, Leann, Ward, Stephen A., Kirk, Kiaran, Fidock, David A.

“…Summary Recent studies have highlighted the importance of a parasite protein referred to as the chloroquine resistance transporter (PfCRT) in the molecular…”
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Saquinavir Inhibits the Malaria Parasite's Chloroquine Resistance Transporter by Martin, Rowena E, Butterworth, Alice S, Gardiner, Donald L, Kirk, Kiaran, McCarthy, James S, Skinner-Adams, Tina S

“…The antiretroviral protease inhibitors (APIs) ritonavir, saquinavir, and lopinavir, used to treat HIV infection, inhibit the growth of Plasmodium falciparum at…”
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1H-NMR metabolite profiles of different strains of Plasmodium falciparum by Teng, Rongwei, Lehane, Adele M, Winterberg, Markus, Shafik, Sarah H, Summers, Robert L, Martin, Rowena E, van Schalkwyk, Donelly A, Junankar, Pauline R, Kirk, Kiaran

“…Although efforts to understand the basis for inter-strain phenotypic variation in the most virulent malaria species, Plasmodium falciparum, have benefited from…”
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Functional characteristics of the malaria parasite's "chloroquine resistance transporter": Implications for chemotherapy by Summers, Robert L., Martin, Rowena E.

“…Chloroquine (CQ) was the best and most heavily used drug in the fight against malaria.  However, the effectiveness of CQ has declined with the emergence and…”
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Membrane transport proteins of the malaria parasite by Martin, Rowena E, Ginsburg, Hagai, Kirk, Kiaran

“…The malaria parasite-infected erythrocyte is a multi-compartment structure, incorporating numerous different membrane systems. The movement of nutrients,…”
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Mechanisms of resistance to the partner drugs of artemisinin in the malaria parasite by Martin, Rowena E, Shafik, Sarah H, Richards, Sashika N

“…•New targets and resistance determinants have been identified for ACT partner drugs.•Resistance to many of the ACT partner drugs involves multifactorial…”
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A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum by Marchetti, Rosa V., Lehane, Adele M., Shafik, Sarah H., Winterberg, Markus, Martin, Rowena E., Kirk, Kiaran

“…The intraerythrocytic malaria parasite relies primarily on glycolysis to fuel its rapid growth and reproduction. The major byproduct of this metabolism, lactic…”
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