Search Results - "Martin, Roger"

Racing Odysseus: A College President Becomes a Freshman Again by Roger H. Martin

“…The idea of reliving youth is a common fantasy, but who among us is actually courageous enough to try it? After surviving a deadly cancer against tremendous…”
Get full text

Abscopal effects of radiation therapy: A clinical review for the radiobiologist by Siva, Shankar, MacManus, Michael P, Martin, Roger F, Martin, Olga A

“…Abstract An “abscopal” effect occurs when localized irradiation perturbs the organism as a whole, with consequences that can be either beneficial or…”
Get full text

Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research by Ivashkevich, Alesia, Redon, Christophe E, Nakamura, Asako J, Martin, Roger F, Martin, Olga A

“…Abstract Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis for a sensitive assay of DNA damage in human biopsies. The…”
Get full text

The critical role of QM/MM X-ray refinement and accurate tautomer/protomer determination in structure-based drug design by Borbulevych, Oleg Y., Martin, Roger I., Westerhoff, Lance M.

“…Conventional protein:ligand crystallographic refinement uses stereochemistry restraints coupled with a rudimentary energy functional to ensure the correct…”
Get full text

Rethinking the M&A model: give value to get value by Martin, Roger L

“…[...]not many acquires have the capability to successfully acquire. [...]corporate M&A is often a mug’s game in which typically 70 percent to 90 percent of…”
Get full text

MovableType Software for Fast Free Energy-Based Virtual Screening: Protocol Development, Deployment, Validation, and Assessment by Zheng, Zheng, Borbulevych, Oleg Y, Liu, Hao, Deng, Jianpeng, Martin, Roger I, Westerhoff, Lance M

“…For decades, the complicated energy surfaces found in macromolecular protein:ligand structures, which require large amounts of computational time and resources…”
Get full text

High‐throughput quantum‐mechanics/molecular‐mechanics (ONIOM) macromolecular crystallographic refinement with PHENIX/DivCon: the impact of mixed Hamiltonian methods on ligand and protein structure by Borbulevych, Oleg, Martin, Roger I., Westerhoff, Lance M.

“…Conventional macromolecular crystallographic refinement relies on often dubious stereochemical restraints, the preparation of which often requires human…”
Get full text

9th international symposium on physical, molecular, cellular, and medical aspects of Auger processes: preface by Vallis, Katherine A, Martin, Roger F., Falzone, Nadia

Get full text

An approach to assessing the contribution of the high LET effect in strategies for Auger endoradiotherapy by Lobachevsky, Pavel, Skene, Colin, Munforte, Laura, Smith, Andrea, White, Jonathan, Martin, Roger F.

“…Purpose: The interest in exploiting Auger emitters in cancer therapy stems from their high linear energy transfer (LET)-type radiation damage to DNA. However,…”
Get full text

Models & misadventures: the perfectible machine fallacy by Martin, Roger L

“…Purpose The author argues that the model for the management of the U.S. economy and businesses – one that assumes that they can be run like machines –is…”
Get full text

What's Changed in 75 Years of RadRes? – An Australian Perspective on Selected Topics by Martin, Olga A., Sykes, Pamela J., Lavin, Martin, Engels, Elette, Martin, Roger F.

“…Several scientific themes are reviewed in the context of the 75-year period relevant to this special platinum issue of Radiation Research. Two criteria have…”
Get full text

The quest to exploit the Auger effect in cancer radiotherapy - a reflective review by Martin, Roger F., Feinendegen, Ludwig E.

“…To identify the emergence of the recognition of the potential of the Auger effect for clinical application, and after tracing the salient milestones towards…”
Get full text

Chemical Repair of Radical Damage to the GC Base Pair by DNA-Bound Bisbenzimidazoles by Anderson, Robert F., Shinde, Sujata S., Andrau, Laura, Leung, Brenda, Skene, Colin, White, Jonathan M., Lobachevsky, Pavel N., Martin, Roger F.

“…The migration of an electron-loss center (hole) in calf thymus DNA to bisbenzimidazole ligands bound in the minor groove is followed by pulse radiolysis…”
Get full text

A Bayesian Approach for Prediction of Patient Radiosensitivity by Herschtal, Alan, Martin, Roger F., Leong, Trevor, Lobachevsky, Pavel, Martin, Olga A.

“…A priori identification of the small proportion of radiation therapy patients who prove to be severely radiosensitive is a long-held goal in radiation…”
Get full text

Cancer Radiotherapy: Understanding the Price of Tumor Eradication by Martin, Olga A, Martin, Roger F

Get full text

Compromized DNA repair as a basis for identification of cancer radiotherapy patients with extreme radiosensitivity by Lobachevsky, Pavel, Leong, Trevor, Daly, Patricia, Smith, Jai, Best, Nickala, Thompson, Ella R, Li, Na, Campbell, Ian G, Martin, Roger F, Martin, Olga A

“…Abstract A small percentage of cancer radiotherapy patients develop abnormally severe side effects as a consequence of intrinsic radiosensitivity. We analysed…”
Get full text

Mobilization of Viable Tumor Cells Into the Circulation During Radiation Therapy by Martin, Olga A., PhD, Anderson, Robin L., PhD, Russell, Prudence A., MD, Ashley Cox, R., FRCR, Ivashkevich, Alesia, PhD, Swierczak, Agnieszka, PhD, Doherty, Judy P., BSc (Hons), Jacobs, Daphne H.M., BSc, Smith, Jai, BSc (Hons), Siva, Shankar, FRANZCR, Daly, Patricia E., FFRRCSI, Ball, David L., FRANZCR, Martin, Roger F., PhD, MacManus, Michael P., FRANZCR

“…Purpose To determine whether radiation therapy (RT) could mobilize viable tumor cells into the circulation of non-small cell lung cancer (NSCLC) patients…”
Get full text

Radiation Therapy Modulates DNA Repair Efficiency in Peripheral Blood Mononuclear Cells of Patients With Non-Small Cell Lung Cancer by Yin, Xiaoyu, Mason, Joel, Lobachevsky, Pavel N., Munforte, Laura, Selbie, Lisa, Ball, David L., Martin, Roger F., Leong, Trevor, Siva, Shankar, Martin, Olga A.

“…There is growing interest in developing individually tailored cancer radiation therapy (RT), wherein patients with high intrinsic radiosensitivity are…”
Get full text

XModeScore: a novel method for accurate protonation/tautomer-state determination using quantum-mechanically driven macromolecular X-ray crystallographic refinement by Borbulevych, Oleg, Martin, Roger I., Tickle, Ian J., Westerhoff, Lance M.

“…Gaining an understanding of the protein–ligand complex structure along with the proper protonation and explicit solvent effects can be important in obtaining…”
Get full text

After the fall: The global financial crisis as a test of corporate social responsibility theories by Kemper, Alison, Martin, Roger L.

“…In this paper, we look at the development of the set of core corporate social responsibility (CSR) theories in response to Friedman's ascendancy. We assess the…”
Get full text