Search Results - "Martin, Renee S"

Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism by Apparsundaram, Subbu, Stockdale, Daniel J, Henningsen, Robert A, Milla, Marcos E, Martin, Renee S

“…Although several antidepressants (including fluoxetine, imipramine, citalopram, venlafaxine, and duloxetine) are known to inhibit the serotonin transporter…”
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Effects on cerebral blood flow after single doses of the β 2 agonist, clenbuterol, in healthy volunteers and patients with mild cognitive impairment or Parkinson's disease by Lodeweyckx, Thomas, de Hoon, Jan, Van Laere, Koen, Bautista, Edgar, Rizzo, Gaia, Bishop, Courtney, Rabiner, Eugenii, Martin, Renee S, Ford, Anthony, Vargas, Gabriel

“…Cerebral hypometabolism occurs years prior to a diagnosis of neurodegenerative diseases and coincides with reduced cerebral perfusion and declining…”
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Kinetic and thermodynamic assessment of binding of serotonin transporter inhibitors by Martin, Renee S, Henningsen, Robert A, Suen, Alexander, Apparsundaram, Subbu, Leung, Becky, Jia, Zhongjiang, Kondru, Rama K, Milla, Marcos E

“…Several serotonin reuptake inhibitors are in clinical use for treatment of depression and anxiety disorders. However, to date, reported pharmacological…”
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Effects on cerebral blood flow after single doses of the β2 agonist, clenbuterol, in healthy volunteers and patients with mild cognitive impairment or Parkinson's disease by Lodeweyckx, Thomas, Hoon, Jan, Van Laere, Koen, Bautista, Edgar, Rizzo, Gaia, Bishop, Courtney, Rabiner, Eugenii, Martin, Renee S., Ford, Anthony, Vargas, Gabriel

“…Aims Cerebral hypometabolism occurs years prior to a diagnosis of neurodegenerative diseases and coincides with reduced cerebral perfusion and declining…”
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Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans by Fielden, Mark R., Hassani, Mary, Uppal, Hirdesh, Day-Lollini, Patricia, Button, Donald, Martin, Renee S., Garrido, Rosario, Liu, Xingrong, Kolaja, Kyle L.

“…A number of drugs and drug candidates, including fenfluramine and ergot derivatives, are associated with valvulopathy in humans; however, these responses are…”
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AF‐353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist by Gever, Joel R, Soto, Rothschild, Henningsen, Robert A, Martin, Renee S, Hackos, David H, Panicker, Sandip, Rubas, Werner, Oglesby, Ian B, Dillon, Michael P, Milla, Marcos E, Burnstock, Geoffrey, Ford, Anthony PDW

“…Background and purpose:  Purinoceptors containing the P2X3 subunit (P2X3 homotrimeric and P2X2/3 heterotrimeric) are members of the P2X family of ion channels…”
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Blisibimod for treatment of systemic lupus erythematosus: with trials you become wiser by Scheinberg, Morton A, Hislop, Colin M, Martin, Renee S

“…Blisibimod is a potent and selective inhibitor of B cell activating factor (BAFF), a mediator of differentiation, maturation and survival of B cells. It has a…”
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A 5-HT4 Receptor Transmembrane Network Implicated in the Activity of Inverse Agonists but Not Agonists by Joubert, Lara, Claeysen, Sylvie, Sebben, Michèle, Bessis, Anne-Sophie, Clark, Robin D., Martin, Renee S., Bockaert, Joël, Dumuis, Aline

“…Activation of G protein-coupled receptors is thought to involve disruption of intramolecular interactions that stabilize their inactive conformation. Such…”
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Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease by Matt, Rachel A, Martin, Renee S, Evans, Andrew K, Gever, Joel R, Vargas, Gabriel A, Shamloo, Mehrdad, Ford, Anthony P

“…Adrenoceptors (ARs) throughout the brain are stimulated by noradrenaline originating mostly from neurons of the locus coeruleus, a brainstem nucleus that is…”
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Cognitive Effects of Three β-Adrenoceptor Acting Drugs in Healthy Volunteers and Patients with Parkinson’s Disease by Eijsvogel, Pepijn P.N.M., Borghans, Laura G.J.M., Prins, Samantha, Moss, Laurence, van Kraaij, Sebastiaan J.W., van Brummelen, Emilie, Klaassen, Erica, Martin, Renee S., Bautista, Edgar, Ford, Anthony P., Kremer, Philip H.C., Groeneveld, Geert Jan, Vargas, Gabriel A.

“…Background: Noradrenergic signaling declines in Parkinson’s disease (PD) following locus coeruleus neurodegeneration. Epidemiologic studies demonstrate that…”
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Highly potent, non-basic 5-HT6 ligands. Site mutagenesis evidence for a second binding mode at 5-HT6 for antagonism by Harris, Ralph N., Stabler, Russel S., Repke, David B., Kress, James M., Walker, Keith A., Martin, Renee S., Brothers, Julie M., Ilnicka, Mariola, Lee, Simon W., Mirzadegan, Tara

“…A series of 5-HT6 ligands derived from (R)-1-(amino)methyl-6-(phenyl)sulfonyltetralin was prepared that yielded several neutral, non-basic analogs having…”
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3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists by ZHAO, Shu-Hai, BERGER, Jacob, CLARK, Robin D, SETHOFER, Steven G, KRAUSS, Nancy E, BROTHERS, Julie M, MARTIN, Renee S, MISNER, Dinah L, SCHWAB, Dietmar, ALEXANDROVA, Ludmila

“…A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT(6) receptor antagonists. Many of the compounds…”
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Effects of cannabinoid receptor ligands on psychosis-relevant behavior models in the rat by MARTIN, Renee S, SECCHI, Robert L, SUNG, Eric, LEMAIRE, Martine, BONHAUS, Douglas W, HEDLEY, Linda R, LOWE, David A

“…Marijuana is known to have psychotropic effects in humans. In this study, we used rat models of sensorimotor gating, hyperactivity and stereotypy to explore…”
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A phase 2, randomised, placebo-controlled clinical trial of blisibimod, an inhibitor of B cell activating factor, in patients with moderate-to-severe systemic lupus erythematosus, the PEARL-SC study by Furie, R A, Leon, G, Thomas, M, Petri, M A, Chu, A D, Hislop, C, Martin, R S, Scheinberg, M A

“…To evaluate the efficacy and safety of subcutaneous blisibimod, an inhibitor of B cell activating factor, in patients with systemic lupus erythematosus (SLE)…”
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Highly potent, non-basic 5-HT sub(6) ligands. Site mutagenesis evidence for a second binding mode at 5-HT sub(6) for antagonism by Harris, Ralph N, Stabler, Russel S, Repke, David B, Kress, James M, Walker, Keith A, Martin, Renee S, Brothers, Julie M, Ilnicka, Mariola, Lee, Simon W, Mirzadegan, Tara

“…A series of 5-HT sub(6) ligands derived from (R)-1-(amino)methyl-6-(phenyl)sulfonyltetralin was prepared that yielded several non-basic analogs having…”
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Thermodynamic analysis of P2X7 purinoceptor ligand binding by Martin, Renee S, Weber, Patrick, Apparsundaram, Subbu, Milla, Marcos E, Gever, Joel R, Panicker, Sandip, Hackos, David H, Henningsen, Robert

“…The P2X7 receptor is known to mediate cytokine release (IL‐1β and IL‐18) from various immune cell types and consequently, is a target for antagonist discovery…”
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Interactions at the human ether a go‐go (hERG) potassium channel investigated through multiple radioligands by Au, Eugene, Vu, Amanda, Ly, Justin Q, Misner, Dinah L, Kondru, Rama K, Martin, Renee S

“…OBJECTIVE AND METHODS The objective of this study was to explore potentially different modes of binding to the hERG channel through competition binding with…”
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Structural and biochemical studies of the SMN oligomerization domain: A novel glycine zipper by Martin, Renee S

“…Spinal Muscular Atrophy (SMA) is a motor neuron degenerative disease that is one of the most common genetic causes of infant mortality, affecting 1 in 6,000…”
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3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT sub(6) receptor antagonists by Zhao, Shu-Hai, Berger, Jacob, Clark, Robin D, Sethofer, Steven G, Krauss, Nancy E, Brothers, Julie M, Martin, Renee S, Misner, Dinah L, Schwab, Dietmar, Alexandrova, Ludmila

“…A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT sub(6) receptor antagonists. Many of the compounds…”
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3,4-Dihydro-2 H-benzo[1,4]oxazine derivatives as 5-HT 6 receptor antagonists by Zhao, Shu-Hai, Berger, Jacob, Clark, Robin D., Sethofer, Steven G., Krauss, Nancy E., Brothers, Julie M., Martin, Renee S., Misner, Dinah L., Schwab, Dietmar, Alexandrova, Ludmila

“…The synthesis and structure–activity relationships of a series of 3,4-dihydro-2 H-benzo[1,4]oxazine based 5-HT 6 antagonists are described. A series of novel…”
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