Search Results - "Martin, R.G"

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice by Chapman, J. Ross, Taylor, Martin R.G., Boulton, Simon J.

“…DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genetic instability. To preserve genome integrity, organisms have evolved several DSB…”
Get full text

The Initial Response of a Eukaryotic Replisome to DNA Damage by Taylor, Martin R.G., Yeeles, Joseph T.P.

“…The replisome must overcome DNA damage to ensure complete chromosome replication. Here, we describe the earliest events in this process by reconstituting…”
Get full text

Dynamics of Replication Fork Progression Following Helicase–Polymerase Uncoupling in Eukaryotes by Taylor, Martin R.G., Yeeles, Joseph T.P.

“…Leading-strand polymerase stalling at DNA damage impairs replication fork progression. Using biochemical approaches, we show this arises due to both slower…”
Get full text

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination by Taylor, Martin R.G., Špírek, Mário, Chaurasiya, Kathy R., Ward, Jordan D., Carzaniga, Raffaella, Yu, Xiong, Egelman, Edward H., Collinson, Lucy M., Rueda, David, Krejci, Lumir, Boulton, Simon J.

“…Repair of DNA double strand breaks by homologous recombination (HR) is initiated by Rad51 filament nucleation on single-stranded DNA (ssDNA), which catalyzes…”
Get full text

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling by Taylor, Martin R.G., Špírek, Mário, Jian Ma, Chu, Carzaniga, Raffaella, Takaki, Tohru, Collinson, Lucy M., Greene, Eric C., Krejci, Lumir, Boulton, Simon J.

“…Central to homologous recombination in eukaryotes is the RAD51 recombinase, which forms helical nucleoprotein filaments on single-stranded DNA (ssDNA) and…”
Get full text

Extension of the ADI-FDTD method to Debye media by Garcia, S.G., Rubio, R.G., Bretones, A.R., Martin, R.G.

“…This paper describes an extension of the alternating direction implicit finite-difference time-domain (ADI-FDTD) method to analyze problems involving Debye…”
Get full text

Benchmark Antenna Problems for Evolutionary Optimization Algorithms by Pantoja, M.F., Bretones, A.R., Martin, R.G.

“…A set of antenna-optimization problems is presented that satisfies the necessary requirements to form a test suite useful for measuring and comparing the…”
Get full text

A hybrid time-domain technique that combines the finite element, finite difference and method of moment techniques to solve complex electromagnetic problems by Monorchio, A., Bretones, A.R., Mittra, R., Manara, G., Martin, R.G.

“…This paper describes a hybrid technique directly operating in time domain that combines the finite element time domain (FETD), the finite-difference…”
Get full text

GA design of a thin-wire bow-tie antenna for GPR applications by van Coevorden, C.Md.J., Bretones, A.R., Pantoja, M.F., Ruiz, F.J.G., Garcia, S.G., Martin, R.G.

“…A microgenetic algorithm has been applied to design a new ultrawideband thin-wire bow-tie antenna for ground-penetrating radar applications. The broadband…”
Get full text

Measurement of Amino Acid Levels in the Vitreous Humor of Rats after Chronic Intraocular Pressure Elevation or Optic Nerve Transection by Levkovitch-Verbin, Hana, Martin, Keith R.G, Quigley, Harry A, Baumrind, Lisa A, Pease, Mary Ellen, Valenta, Danielle

“…PURPOSETo investigate whether the levels of free amino acids and protein in the vitreous of rat eyes are altered with chronic intraocular pressure (IOP)…”
Get full text

On the dispersion relation of ADI-FDTD by Garcia, S.G., Rubio, R.G., Bretones, A.R., Martin, R.G.

“…In this letter, we analyze the alternating direction implicit finite-difference time-domain (ADI-FDTD) dispersion relation and find the numerical plane-wave…”
Get full text

On the physical nature of accretion disc viscosity by Martin, R.G., Nixon, C.J., Pringle, J.E., Livio, M.

“…•Observations suggest that the dimensionless viscosity parameter α∼0.2−0.3.•In fully ionised discs the strength of the turbulence is always limited to…”
Get full text

Fast and efficient DNA replication with purified human proteins by Baris, Yasemin, Taylor, Martin R. G., Aria, Valentina, Yeeles, Joseph T. P.

“…Chromosome replication is performed by a complex and intricate ensemble of proteins termed the replisome, where the DNA polymerases Polδ and Polε, DNA…”
Get full text

Structure of a human replisome shows the organisation and interactions of a DNA replication machine by Jones, Morgan L, Baris, Yasemin, Taylor, Martin R G, Yeeles, Joseph T P

“…The human replisome is an elaborate arrangement of molecular machines responsible for accurate chromosome replication. At its heart is the CDC45‐MCM‐GINS (CMG)…”
Get full text

The transcription factor c-jun is activated in retinal ganglion cells in experimental rat glaucoma by Levkovitch-Verbin, Hana, Quigley, Harry A., Martin, Keith R.G., Harizman, Noga, Valenta, Danielle F., Pease, Mary Ellen, Melamed, Shlomo

“…This study investigates the role of the MAP kinase pathway including c-jun, ATF-2 and JNK in glaucomatous eyes of rats and in optic nerve transection. Glaucoma…”
Get full text

Microstrip-patch array design using a multiobjective GA by van Coevorden, C.M.D.J., Garcia, S.G., Pantoja, M.F., Bretones, A.R., Martin, R.G.

“…A Pareto multiobjective genetic algorithm (MOGA) has been applied to optimize the radiation characteristics of a 4/spl times/4 array of parasitically loaded…”
Get full text

Manufacturing of thermoplastic composite sandwich panels using induction welding under vacuum by Martin, R.G., Johansson, C., Tavares, J.R., Dubé, M.

“…A new method to manufacture thermoplastic composite sandwich panels is presented, making use of the induction welding process in which a magnetic susceptor…”
Get full text

GA design of small thin-wire antennas: comparison with Sierpinsky-type prefractal antennas by Pantoja, M.F., Ruiz, F.G., Bretones, A.R., Garcia, S.G., Martin, R.G., Arbesu, J.M.G., Romeu, J., Rius, J.M., Werner, P.L., Werner, D.H.

“…A new set of genetically generated electrically small thin-wire antennas with a better performance than that of several families of Sierpinsky prefractal…”
Get full text

Crank-Nicolson Reformulation of ADI-FDTD PML Extensions by Rubio, R.G., Garcia, S.G., Bretones, A.R., Martin, R.G.

“…The usual approach found in the literature to extend the perfectly matched layers (PMLs) absorbing technique to the alternating direction implicit…”
Get full text

Gene delivery to the eye using adeno-associated viral vectors by Martin, Keith R.G, Klein, Ronald L, Quigley, Harry A

“…Adeno-associated virus (AAV) vectors provide a useful way to deliver genes to the eye. They have a number of important properties which make them suitable for…”
Get full text