Search Results - "Martin, Pauline L."

A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors by Moores, Sheri L, Chiu, Mark L, Bushey, Barbara S, Chevalier, Kristen, Luistro, Leopoldo, Dorn, Keri, Brezski, Randall J, Haytko, Peter, Kelly, Thomas, Wu, Sheng-Jiun, Martin, Pauline L, Neijssen, Joost, Parren, Paul W H I, Schuurman, Janine, Attar, Ricardo M, Laquerre, Sylvie, Lorenzi, Matthew V, Anderson, G Mark

“…Non-small cell lung cancers (NSCLC) with activating EGFR mutations become resistant to tyrosine kinase inhibitors (TKI), often through second-site mutations in…”
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Concordance of preclinical and clinical pharmacology and toxicology of monoclonal antibodies and fusion proteins: soluble targets by Martin, Pauline L, Bugelski, Peter J

“…Monoclonal antibodies (mAbs) and fusion proteins directed towards soluble targets make an important contribution to the treatment of disease. The purpose of…”
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Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets by Bugelski, Peter J, Martin, Pauline L

“…Monoclonal antibodies (mAbs) and fusion proteins directed towards cell surface targets make an important contribution to the treatment of disease. The purpose…”
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Development in the cynomolgus macaque following administration of ustekinumab, a human anti-il-12/23p40 monoclonal antibody, during pregnancy and lactation by Martin, Pauline L., Sachs, Clifford, Imai, Noritaka, Tsusaki, Hideshi, Oneda, Satoru, Jiao, Qun, Treacy, George

“…BACKGROUND: Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of interleukin (IL) 12 and IL‐23 and inhibits their pharmacological…”
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Developmental and reproductive toxicology studies in nonhuman primates by Chellman, Gary J., Bussiere, Jeanine L., Makori, Norbert, Martin, Pauline L., Ooshima, Yojiro, Weinbauer, Gerhard F.

“…Developmental and reproductive toxicology testing in nonhuman primates (NHPs) has become more common due to the increasing number of biopharmaceuticals in drug…”
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Considerations for the nonclinical safety evaluation of antibody drug conjugates for oncology by Roberts, Stanley A., Andrews, Paul A., Blanset, Diann, Flagella, Kelly M., Gorovits, Boris, Lynch, Carmel M., Martin, Pauline L., Kramer-Stickland, Kimberly, Thibault, Stephane, Warner, Garvin

“…•Studies and strategies for design and conduct of ADC nonclinical safety assessment are discussed.•Complexity of ADC’s require a case-by-case…”
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Effects of an Anti-TNF-α Monoclonal Antibody, Administered Throughout Pregnancy and Lactation, on the Development of the Macaque Immune System by Martin, Pauline L., Oneda, Satoru, Treacy, George

“…Problem  The use of anti‐TNF‐α therapies during pregnancy and lactation on the development of the neonatal immune system has not been fully established. The…”
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Safety Pharmacology of Anticancer Agents by Martin, Pauline L

“…The safety pharmacology testing for anticancer agents has historically differed for small molecule pharmaceutical drugs versus large-molecule…”
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Absence of Adverse Effects in Cynomolgus Macaques Treated with CNTO 95, a Fully Human Anti-αv Integrin Monoclonal Antibody, Despite Widespread Tissue Binding by MARTIN, Pauline L, QUN JIAO, ANDERSON, Lisa, GRAHAM, Martin A, DAVIS, Hugh M, TREACY, George, CORNACOFF, Joel, HALL, William, SAVILLE, Bradley, NEMETH, Jeffrey A, SCHANTZ, Allen, MATA, Marielena, JANG, Haishan, FASANMADE, Adedigbo A

“…Purpose: CNTO 95 is a fully human anti-αv integrin monoclonal antibody that inhibits macaque and rodent angiogenesis and inhibits human tumor growth in…”
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Considerations in assessing the developmental and reproductive toxicity potential of biopharmaceuticals by Martin, Pauline L., Breslin, William, Rocca, Meredith, Wright, David, Cavagnaro, Joy

“…This report discusses the principles of developmental and reproductive toxicity (DART) testing for biopharmaceuticals. Biopharmaceuticals are…”
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Developmental Toxicity Testing of Biopharmaceuticals in Nonhuman Primates: Previous Experience and Future Directions by Martin, Pauline L., Weinbauer, Gerhard F.

“…Developmental toxicity studies for pharmaceutical safety testing are designed to evaluate potential adverse effects of drug treatment on pregnancy and on the…”
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Placental Transfer of Fc-Containing Biopharmaceuticals across Species, an Industry Survey Analysis by Bowman, Christopher J., Breslin, William J., Connor, Anu V., Martin, Pauline L., Moffat, Graeme J., Sivaraman, Lakshmi, Tornesi, M. Belen, Chivers, Simon

“…BACKGROUND Understanding species differences in placental transfer of Fc‐containing biopharmaceuticals (particularly monoclonal antibodies) will improve human…”
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Unexpected Toxicology Findings in Rats Dosed With an Antihuman IL-13 Monoclonal Antibody by Martin, Pauline L., Nnane, Ivo P., Branigan, Patrick, Louden, Calvert

“…Interleukin 13 (IL-13) is a type 2 helper T cytokine involved in allergic inflammation and immune responses to parasites. CNTO5825 is an antihuman IL-13…”
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Considerations Regarding Nonhuman Primate Use in Safety Assessment of Biopharmaceuticals by Buckley, Lorrene A., Chapman, Kathryn, Burns-Naas, Leigh Ann, Todd, Marque D., Martin, Pauline L., Lansita, Janice A.

“…Selection of a pharmacologically responsive species can represent a major challenge in designing nonclinical safety assessment programs for many…”
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Effects of CNTO 530, an erythropoietin mimetic-IgG4 fusion protein, on embryofetal development in rats and rabbits by Martin, Pauline L., Sachs, Clifford, Hoberman, Alan, Jiao, Qun, Bugelski, Peter J.

“…BACKGROUND: CNTO 530is a biopharmaceutical consisting of a novel peptide that mimics the actions of erythropoietin, fused to the Fc fragment of human IgG4…”
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Ocular inflammation in cynomolgus macaques following intravenous administration of a human monoclonal antibody by Martin, Pauline L, Miller, Paul E, Mata, Marielena, Christian, Brian J

“…Angiogenesis is a major component of the pathogenesis of various ocular diseases, including age-related macular degeneration (AMD). CNTO95 is a fully human…”
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Preclinical Safety and Pharmacology of an Anti-Human Interleukin-13 Monoclonal Antibody in Normal Macaques and in Macaques with Allergic Asthma by Martin, Pauline L., Fisher, Dusti, Glass, William, O’Neil, Karyn, Das, Anuk, Martin, Elise C., Li, Li

“…Interleukin-13 (IL-13) plays a central role in chronic airway diseases, including asthma. These studies were conducted to evaluate the safety of administration…”
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Effects of Administration of a Monoclonal Antibody against Mouse Tumor Necrosis Factor Alpha during Pregnancy and Lactation on the Pre- and Postnatal Development of the Mouse Immune System by Martin, Pauline L., Cornacoff, Joel B., Treacy, George, Eirikas, Edward, Marini, Joseph, White, Kimber L., Peachee, Vanessa, Hoberman, Alan

“…Monoclonal antibodies directed against tumor necrosis factor alpha (TNFα) are currently employed in the treatment of various immune-mediated diseases. These…”
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Increases in adipose and total body weight, but not in lean body mass, associated with subcutaneous administration of Sonic hedgehog-Ig fusion protein to mice by Martin, Pauline L., Lane, Joan, Pouliot, Louise, Gains, Malcolm, Stejskal, Rudolph, Smith, Susan Yvonne, Galdes, Alphonse, Green, James

“…Sonic hedgehog (Shh) is a member of a family of proteins that are involved in embryonic development. The receptor signaling pathways for Shh persist in adults…”
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Pharmacology and placental transfer of a human αv integrin monoclonal antibody in rabbits by Martin, Pauline L., Zhou, Zhao, Van den Bulck, Kathleen, Kwok, Deborah, Powers, Gordon, Jiao, Qun, Schantz, Allen, Treacy, George

“…BACKGROUND: Intetumumab is a human IgG1 anti‐αv‐integrin monoclonal antibody that inhibits angiogenesis. Integrin binding and angiogenesis are important in…”
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