Search Results - "Martin, Kirsty J."

Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins by Remenyi, Judit, Hunter, Christopher J, Cole, Christian, Ando, Hideaki, Impey, Soren, Monk, Claire E, Martin, Kirsty J, Barton, Geoffrey J, Hutvagner, Gyorgy, Arthur, J Simon C

“…Neurotrophins are growth factors that are important in neuronal development and survival as well as synapse formation and plasticity. Many of the effects of…”
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Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments by Martin, Kirsty J, McGhee, Ewan J, Schwarz, Juliana P, Drysdale, Martin, Brachmann, Saskia M, Stucke, Volker, Sansom, Owen J, Anderson, Kurt I

“…FRET biosensors have proven very useful tools for studying the activation of specific signalling pathways in living cells. Most biosensors designed to date…”
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Ketogenic diets for drug-resistant epilepsy by Martin-McGill, Kirsty J, Jackson, Cerian F, Bresnahan, Rebecca, Levy, Robert G, Cooper, Paul N

“…Ketogenic diets (KDs), being high in fat and low in carbohydrates, have been suggested to reduce seizure frequency in people with epilepsy. At present, such…”
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A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion by Kavanagh, Deirdre M., Smyth, Annya M., Martin, Kirsty J., Dun, Alison, Brown, Euan R., Gordon, Sarah, Smillie, Karen J., Chamberlain, Luke H., Wilson, Rhodri S., Yang, Lei, Lu, Weiping, Cousin, Michael A., Rickman, Colin, Duncan, Rory R.

“…Neuronal synapses are among the most scrutinized of cellular systems, serving as a model for all membrane trafficking studies. Despite this, synaptic biology…”
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Secretory vesicles are preferentially targeted to areas of low molecular SNARE density by Yang, Lei, Dun, Alison R, Martin, Kirsty J, Qiu, Zhen, Dunn, Andrew, Lord, Gabriel J, Lu, Weiping, Duncan, Rory R, Rickman, Colin

“…Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide…”
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Selective kinase inhibitors as tools for neuroscience research by Martin, Kirsty J., Arthur, J. Simon C.

“…Signal transduction cascades, including the MAPK, PI3 kinase, Ca2+ and PKC pathways, play important roles in neurons downstream of multiple signals including…”
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Biochemical assessment of patients following ketogenic diets for epilepsy: Current practice in the UK and Ireland by Schoeler, Natasha E., Simpson, Zoe, Whiteley, Victoria J., Nguyen, Patty, Meskell, Rachel, Lightfoot, Kathyrn, Martin‐McGill, Kirsty J., Olpin, Simon, Ivison, Fiona

“…Objective Biochemical assessment is recommended for patients prior to initiating and following a ketogenic diet (KD). There is no published literature…”
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MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins by Hunter, Chris J., Remenyi, Judit, Correa, Sonia A., Privitera, Lucia, Reyskens, Kathleen M. S. E., Martin, Kirsty J., Toth, Rachel, Frenguelli, Bruno G., Arthur, J. Simon C.

“…The immediate early gene activity‐regulated cytoskeletal protein (Arc)/Arg3.1 and the neurotrophin brain‐derived neurotrophic factor (BDNF) play important…”
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Felbamate add-on therapy for drug-resistant focal epilepsy by Shi, Li Li, Bresnahan, Rebecca, Martin-McGill, Kirsty J, Dong, JianCheng, Ni, HengJian, Geng, JinSong

“…This is an updated version of the Cochrane Review previously published in 2017.Epilepsy is a chronic and disabling neurological disorder, affecting…”
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Keto-on-the-Clock: A Survey of Dietetic Care Contact Time Taken to Provide Ketogenic Diets for Drug-Resistant Epilepsy in the UK by Lambert, Bridget, Lightfoot, Kathryn, Meskell, Rachel, Whiteley, Victoria J., Martin-McGill, Kirsty J., Schoeler, Natasha E.

“…Medical ketogenic diets (KDs) are effective yet resource-intensive treatment options for drug-resistant epilepsy (DRE). We investigated dietetic care contact…”
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Sulthiame add-on therapy for epilepsy by Bresnahan, Rebecca, Martin-McGill, Kirsty J, Milburn-McNulty, Philip, Powell, Graham, Sills, Graeme J, Marson, Anthony G

“…This is an updated version of the Cochrane Review previously published in the Cochrane Database of Systematic Reviews 2015, Issue 10. Epilepsy is a common…”
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N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis by Juin, Amelie, Spence, Heather J., Martin, Kirsty J., McGhee, Ewan, Neilson, Matthew, Cutiongco, Marie F.A., Gadegaard, Nikolaj, Mackay, Gillian, Fort, Loic, Lilla, Sergio, Kalna, Gabriela, Thomason, Peter, Koh, Yvette W.H., Norman, Jim C., Insall, Robert H., Machesky, Laura M.

“…Pancreatic ductal adenocarcinoma is one of the most invasive and metastatic cancers and has a dismal 5-year survival rate. We show that N-WASP drives…”
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The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review by Martin-McGill, Kirsty J, Srikandarajah, Nisaharan, Marson, Anthony G, Tudur Smith, Catrin, Jenkinson, Michael D

“…We performed a systematic review of the evidence for effectiveness and acceptability of different ketogenic diets (KDs) in the therapeutic management of…”
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Fam49/CYRI interacts with Rac1 and locally suppresses protrusions by Fort, Loic, Batista, José Miguel, Thomason, Peter A., Spence, Heather J., Whitelaw, Jamie A., Tweedy, Luke, Greaves, Jennifer, Martin, Kirsty J., Anderson, Kurt I., Brown, Peter, Lilla, Sergio, Neilson, Matthew P., Tafelmeyer, Petra, Zanivan, Sara, Ismail, Shehab, Bryant, David M., Tomkinson, Nicholas C. O., Chamberlain, Luke H., Mastick, Grant S., Insall, Robert H., Machesky, Laura M.

“…Actin-based protrusions are reinforced through positive feedback, but it is unclear what restricts their size, or limits positive signals when they retract or…”
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Ketogenic diets as an adjuvant therapy in glioblastoma (the KEATING trial): study protocol for a randomised pilot study by Martin-McGill, Kirsty J, Marson, Anthony G, Tudur Smith, Catrin, Jenkinson, Michael D

“…Glioblastoma is the commonest form of malignant brain tumour in adults, affecting 2-3 people per 100,000 per year. Despite current treatment options including…”
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Ketogenic diets for drug-resistant epilepsy by Martin-McGill, Kirsty J, Bresnahan, Rebecca, Levy, Robert G, Cooper, Paul N

“…Ketogenic diets (KDs) are high in fat and low in carbohydrates and have been suggested to reduce seizure frequency in people with epilepsy. Such diets may be…”
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MSK1 regulates homeostatic and experience-dependent synaptic plasticity by Corrêa, Sonia A L, Hunter, Christopher J, Palygin, Oleg, Wauters, Sandrine C, Martin, Kirsty J, McKenzie, Colin, McKelvey, Kim, Morris, Richard G M, Pankratov, Yuriy, Arthur, J Simon C, Frenguelli, Bruno G

“…The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the…”
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CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling by Naqvi, Shaista, Martin, Kirsty J, Arthur, J Simon C

“…CREB (cAMP-response-element-binding protein) is an important transcription factor for the activation of a number of immediate early genes. CREB is…”
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Carisbamate add-on therapy for drug-resistant focal epilepsy by Lu, Chuansen, Zheng, Jinou, Cao, Yue, Bresnahan, Rebecca, Martin-McGill, Kirsty J

“…Epilepsy is one of the most common neurological disorders. Many people with epilepsy are drug-resistant and require add-on therapy, meaning that they…”
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Munc18-1 Protein Molecules Move between Membrane Molecular Depots Distinct from Vesicle Docking Sites by Smyth, Annya M., Yang, Lei, Martin, Kirsty J., Hamilton, Charlotte, Lu, Weiping, Cousin, Michael A., Rickman, Colin, Duncan, Rory R.

“…Four evolutionarily conserved proteins are required for mammalian regulated exocytosis: three SNARE proteins, syntaxin, SNAP-25, and synaptobrevin, and the SM…”
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