Search Results - "Martin, Keith R."

Diabetic retinopathy: a complex pathophysiology requiring novel therapeutic strategies by Whitehead, Michael, Wickremasinghe, Sanjeewa, Osborne, Andrew, Van Wijngaarden, Peter, Martin, Keith R

“…Diabetic retinopathy (DR) is the leading cause of vision loss in the working age population of the developed world. DR encompasses a complex pathology, and one…”
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Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet‐Derived Growth Factor on Human Retinal Ganglion Cells by Osborne, Andrew, Sanderson, Julie, Martin, Keith R.

“…Optic neuropathies such as glaucoma occur when retinal ganglion cells (RGCs) in the eye are injured. Strong evidence suggests mesenchymal stem cells (MSCs)…”
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Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial by Garway-Heath, David F, Prof, Crabb, David P, Prof, Bunce, Catey, DSc, Lascaratos, Gerassimos, MSc, Amalfitano, Francesca, BSc, Anand, Nitin, MD, Azuara-Blanco, Augusto, Prof, Bourne, Rupert R, Prof, Broadway, David C, MD, Cunliffe, Ian A, FRCOphth, Diamond, Jeremy P, PhD, Fraser, Scott G, MD, Ho, Tuan A, PhD, Martin, Keith R, Prof, McNaught, Andrew I, MD, Negi, Anil, MD, Patel, Krishna, MSc, Russell, Richard A, PhD, Shah, Ameet, MRCOphth, Spry, Paul G, PhD, Suzuki, Katsuyoshi, PhD, White, Edward T, BSc, Wormald, Richard P, FRCOphth, Xing, Wen, MSc, Zeyen, Thierry G, Prof

“…Summary Background Treatments for open-angle glaucoma aim to prevent vision loss through lowering of intraocular pressure, but to our knowledge no…”
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Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation by Tassoni, Alessia, Gutteridge, Alex, Barber, Amanda C., Osborne, Andrew, Martin, Keith R.

“…A variety of diseases lead to degeneration of retinal ganglion cells (RGCs) and their axons within the optic nerve resulting in loss of visual function…”
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Neuroprotective Effects of Intravitreal Mesenchymal Stem Cell Transplantation in Experimental Glaucoma by Johnson, Thomas V, Bull, Natalie D, Hunt, David P, Marina, Nephtali, Tomarev, Stanislav I, Martin, Keith R

“…Purpose. Retrograde neurotrophic factor transport blockade has been implicated in the pathophysiology of glaucoma. Stem cell transplantation appears to…”
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Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome by JOHNSON, Thomas V, DEKORVER, Nicholas W, TOMAREV, Stanislav I, LEVASSEUR, Victoria A, OSBORNE, Andrew, TASSONI, Alessia, LORBER, Barbara, HELLER, Janosch P, VILLASMIL, Rafael, BULL, Natalie D, MARTIN, Keith R

“…The development of neuroprotective strategies to attenuate retinal ganglion cell death could lead to novel therapies for chronic optic neuropathies such as…”
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Can Home Monitoring Allow Earlier Detection of Rapid Visual Field Progression in Glaucoma? by Anderson, Andrew J., Bedggood, Phillip A., George Kong, Yu Xiang, Martin, Keith R., Vingrys, Algis J.

“…Recent developments in electronic technology are making it possible to home monitor the sensitivity of the central visual field using portable devices. We used…”
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Development and Characterization of an Adult Retinal Explant Organotypic Tissue Culture System as an In Vitro Intraocular Stem Cell Transplantation Model by Johnson, Thomas V, Martin, Keith R

“…To develop and characterize a retinal explant culture system to facilitate investigation of novel methods of improving retinal stem cell therapy. Retinas…”
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Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS by Petrova, Veselina, Pearson, Craig S., Ching, Jared, Tribble, James R., Solano, Andrea G., Yang, Yunfei, Love, Fiona M., Watt, Robert J., Osborne, Andrew, Reid, Evan, Williams, Pete A., Martin, Keith R., Geller, Herbert M., Eva, Richard, Fawcett, James W.

“…Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to…”
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Neurotrophic factor delivery as a protective treatment for glaucoma by Johnson, Thomas V., Bull, Natalie D., Martin, Keith R.

“…Glaucoma is a progressive optic neuropathy and a major cause of visual impairment worldwide. Neuroprotective therapies for glaucoma aim to ameliorate retinal…”
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Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons by Osborne, Andrew, Wang, Aiden X Z, Tassoni, Alessia, Widdowson, Peter S, Martin, Keith R

“…Brain-derived neurotrophic factor (BDNF) acting through the tropomyosin-related receptor-B (TrkB) is an important signaling system for the maintenance and…”
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Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women by Bloomer, Richard J, Pence, Jacquelyn, Hellenbrand, Janine, Davis, Allyson, Davis, Samantha, Stockton, Michelle, Martin, Keith R

“…Maintaining adequate hydration is critical to optimal health, well-being, and performance. Those who are physically active in stressful environments, such as…”
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Identification of a critical sulfation in chondroitin that inhibits axonal regeneration by Pearson, Craig S, Mencio, Caitlin P, Barber, Amanda C, Martin, Keith R, Geller, Herbert M

“…The failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury,…”
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Hemoglobin Video Imaging Detects Differences in Aqueous Outflow Between Eyes With and Without Glaucoma During the Water Drinking Test by Lusthaus, Jed A., Meyer, Paul A.R., McCluskey, Peter J., Martin, Keith R.

“…Hemoglobin video imaging (HVI) demonstrates increased aqueous outflow (AO) in response to the water drinking test (WDT) in patients with and without glaucoma…”
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Identification of Barriers to Retinal Engraftment of Transplanted Stem Cells by Johnson, Thomas V, Bull, Natalie D, Martin, Keith R

“…Intraocular stem cell transplantation may be therapeutic for retinal neurodegenerative diseases such as glaucoma via neuronal replacement and/or…”
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Concise Review: Toward Stem Cell‐Based Therapies for Retinal Neurodegenerative Diseases by Bull, Natalie D., Martin, Keith R.

“…Loss of sight due to irreversible retinal neurodegeneration imposes a significant disease burden on both patients and society. Glaucoma and age‐related macular…”
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Progress in Gene Therapy to Prevent Retinal Ganglion Cell Loss in Glaucoma and Leber’s Hereditary Optic Neuropathy by Ratican, Sara E., Martin, Keith R., Osborne, Andrew

“…The eye is at the forefront of the application of gene therapy techniques to medicine. In the United States, a gene therapy treatment for Leber’s congenital…”
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The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease by Martin, Keith R

“…Regular consumption of fruits and vegetables is strongly associated with a reduced risk of cardiovascular disease (CVD). This effect occurs, in part, because…”
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The Effects of Trabecular Bypass Surgery on Conventional Aqueous Outflow, Visualized by Hemoglobin Video Imaging by Lusthaus, Jed A., Meyer, Paul A.R., Khatib, Tasneem Z., Martin, Keith R.

“…Hemoglobin Video Imaging (HVI) provides a noninvasive method to quantify aqueous outflow (AO) perioperatively. Trabecular bypass surgery (TBS) is able to…”
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Influence of extracellular matrix components on the expression of integrins and regeneration of adult retinal ganglion cells by Vecino, Elena, Heller, Janosch P, Veiga-Crespo, Patricia, Martin, Keith R, Fawcett, James W

“…Retinal ganglion cells (RGCs) are exposed to injury in a variety of optic nerve diseases including glaucoma. However, not all cells respond in the same way to…”
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