Search Results - "Martin, Fredricka C."

Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications by Martin, Fredricka C., Thu Le, Anh, Handforth, Adrian

“…No preclinical method to evaluate potential new medications for essential tremor (ET) is available currently. Although harmaline tremor is a well known animal…”
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Carbenoxolone and mefloquine suppress tremor in the harmaline mouse model of essential tremor by Martin, Fredricka C., Handforth, Adrian

“…Excessive olivo‐cerebellar synchrony is implicated in essential tremor. Because synchrony in some networks is mediated by gap junctions, we examined whether…”
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T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor by Handforth, Adrian, Homanics, Gregg E., Covey, Douglas F., Krishnan, Kathiresan, Lee, Jae Yeol, Sakimura, Kenji, Martin, Fredricka C., Quesada, Arnulfo

“…Essential tremor is a common disorder that lacks molecular targets for therapeutic development. T-type calcium channel activation has been postulated to…”
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Zonisamide for essential tremor: An evaluator-blinded study by Handforth, Adrian, Martin, Fredricka C., Kang, Gail A., Vanek, Zeba

“…In this evaluator‐blinded open‐treatment trial, subjects with moderate/severe upper limb essential tremor were titrated to 300 mg/day zonisamide, or adjusted…”
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Pilot efficacy and tolerability: A randomized, placebo-controlled trial of levetiracetam for essential tremor by Handforth, Adrian, Martin, Fredricka C.

“…The purpose of this pilot single‐site study was to assess efficacy and safety of levetiracetam for essential tremor, using a placebo‐controlled, double‐blind,…”
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Vagus nerve stimulation inhibits harmaline-induced tremor by Krahl, Scott E, Martin, Fredricka C, Handforth, Adrian

“…Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. This system receives rich sensory inputs, including visceral. We hypothesized…”
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Contrasting effects of centromedial and basolateral amygdaloid lesions on stress-related responses in the rat by Grijalva, C V, Levin, E D, Morgan, M, Roland, B, Martin, F C

“…The effects of lesions in the centromedial and basolateral amygdala were examined using three different tests sensitive to the following stress-related…”
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Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications by MARTIN, Fredricka C, ANH THU LE, HANDFORTH, Adrian

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Substance P stimulates IL-1 production by astrocytes via intracellular calcium by Martin, F C, Charles, A C, Sanderson, M J, Merrill, J E

“…There is increasing evidence that local substance P (SP) exacerbates peripheral inflammations, partly by stimulating production of inflammatory cytokines such…”
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Production of interleukin-1 by microglia in response to substance P: role for a non-classical NK-1 receptor by Martin, F C, Anton, P A, Gornbein, J A, Shanahan, F, Merrill, J E

“…Substance P (SP) is a central and peripheral neurotransmitter which has been found in multiple sclerosis plaques. SP stimulates peripheral immune cells and may…”
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Lymphokine induction of rat microglia multinucleated giant cell formation by Lee, T T, Martin, F C, Merrill, J E

“…Multinucleated giant cell formation (MNGC) occurs in central nervous system AIDS. The mechanism of fusion of microglia in these cases is unknown. We…”
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Involvement of Brain Opiate Receptors in the Immune-Suppressive Effect of Morphine by Shavit, Yehuda, Depaulis, Antoine, Martin, Fredricka C., Terman, Gregory W., Pechnick, Robert N., Zane, Cynthia J., Gale, Robert Peter, Liebeskind, John C.

“…We previously reported that a single systemic injection of a high dose of morphine (≥ 20 mg/kg) transiently suppresses splenic natural killer cell cytotoxicity…”
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Suppression of natural killer cell activity by high-dose narcotic anesthesia in rats by Beilin, B, Martin, F C, Shavit, Y, Gale, R P, Liebeskind, J C

“…Suppression of natural killer (NK) cell activity in the postoperative period has been reported in several clinical studies. Endogenous opioids and cerebral…”
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Neurotransmitters and cytokines in CNS pathology by Mitrovic, B, Martin, F C, Charles, A C, Ignarro, L J, Anton, P A, Shanahan, F, Merrill, J E

“…In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves…”
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An alternative method for obtaining high-viability cell suspensions from neonatal mouse brain by Martin, F C, Wiley, C A

“…Cultured brain cells have contributed greatly to our understanding of a variety of neurobiological processes. The ability to culture brain tissue is important…”
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Natural killer cell activity in vasopressin-deficient rats (Brattleboro strain) by Yirmiya, R, Shavit, Y, Ben-Eliyahu, S, Martin, F C, Weiner, H, Liebeskind, J C

“…Several lines of evidence suggest that the neuropeptide vasopressin is involved in the regulation of the immune system. We explored this possibility by…”
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In vivo model of HIV infection of the human brain by Achim, C L, Miners, D K, Burrola, P G, Martin, F C, Wiley, C A

“…Approximately one quarter of the AIDS patients have severe HIV encephalitis with diffuse neuronal damage that may be mediated by immune factors secreted by CNS…”
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