Search Results - "Martin, Elizabeth E."

Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer by Coates, James T, Sun, Sheng, Leshchiner, Ignaty, Thimmiah, Nayana, Martin, Elizabeth E, McLoughlin, Daniel, Danysh, Brian P, Slowik, Kara, Jacobs, Raquel A, Rhrissorrakrai, Kahn, Utro, Filippo, Levovitz, Chaya, Denault, Elyssa, Walmsley, Charlotte S, Kambadakone, Avinash, Stone, James R, Isakoff, Steven J, Parida, Laxmi, Juric, Dejan, Getz, Gad, Bardia, Aditya, Ellisen, Leif W

“…Sacituzumab govitecan (SG), the first antibody-drug conjugate (ADC) approved for triple-negative breast cancer, incorporates the anti-TROP2 antibody hRS7…”
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Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers by Parikh, Aparna R., Leshchiner, Ignaty, Elagina, Liudmila, Goyal, Lipika, Levovitz, Chaya, Siravegna, Giulia, Livitz, Dimitri, Rhrissorrakrai, Kahn, Martin, Elizabeth E., Van Seventer, Emily E., Hanna, Megan, Slowik, Kara, Utro, Filippo, Pinto, Christopher J., Wong, Alicia, Danysh, Brian P., de la Cruz, Ferran Fece, Fetter, Isobel J., Nadres, Brandon, Shahzade, Heather A., Allen, Jill N., Blaszkowsky, Lawrence S., Clark, Jeffrey W., Giantonio, Bruce, Murphy, Janet E., Nipp, Ryan D., Roeland, Eric, Ryan, David P., Weekes, Colin D., Kwak, Eunice L., Faris, Jason E., Wo, Jennifer Y., Aguet, François, Dey-Guha, Ipsita, Hazar-Rethinam, Mehlika, Dias-Santagata, Dora, Ting, David T., Zhu, Andrew X., Hong, Theodore S., Golub, Todd R., Iafrate, A. John, Adalsteinsson, Viktor A., Bardelli, Alberto, Parida, Laxmi, Juric, Dejan, Getz, Gad, Corcoran, Ryan B.

“…During cancer therapy, tumor heterogeneity can drive the evolution of multiple tumor subclones harboring unique resistance mechanisms in an individual patient…”
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Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations by Varkaris, Andreas, Fece de la Cruz, Ferran, Martin, Elizabeth E, Norden, Bryanna L, Chevalier, Nicholas, Kehlmann, Allison M, Leshchiner, Ignaty, Barnes, Haley, Ehnstrom, Sara, Stavridi, Anastasia-Maria, Yuan, Xin, Kim, Janice S, Ellis, Haley, Papatheodoridi, Alkistis, Gunaydin, Hakan, Danysh, Brian P, Parida, Laxmi, Sanidas, Ioannis, Ji, Yongli, Lau, Kayao, Wulf, Gerburg M, Bardia, Aditya, Spring, Laura M, Isakoff, Steven J, Lennerz, Jochen K, Del Vecchio, Kathryn, Pierce, Levi, Pazolli, Ermira, Getz, Gad, Corcoran, Ryan B, Juric, Dejan

“…PIK3CA mutations occur in ∼8% of cancers, including ∼40% of HR-positive breast cancers, where the PI3K-alpha (PI3Kα)-selective inhibitor alpelisib is FDA…”
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Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers by Parikh, Aparna R., Leshchiner, Ignaty, Elagina, Liudmila, Goyal, Lipika, Levovitz, Chaya, Siravegna, Giulia, Livitz, Dimitri, Rhrissorrakrai, Kahn, Martin, Elizabeth E., Van Seventer, Emily E., Hanna, Megan, Slowik, Kara, Utro, Filippo, Pinto, Christopher J., Wong, Alicia, Danysh, Brian P., de la Cruz, Ferran Fece, Fetter, Isobel J., Nadres, Brandon, Shahzade, Heather A., Allen, Jill N., Blaszkowsky, Lawrence S., Clark, Jeffrey W., Giantonio, Bruce, Murphy, Janet E., Nipp, Ryan D., Roeland, Eric, Ryan, David P., Weekes, Colin D., Kwak, Eunice L., Faris, Jason E., Wo, Jennifer Y., Aguet, François, Dey-Guha, Ipsita, Hazar-Rethinam, Mehlika, Dias-Santagata, Dora, Ting, David T., Zhu, Andrew X., Hong, Theodore S., Golub, Todd R., Iafrate, A. John, Adalsteinsson, Viktor A., Bardelli, Alberto, Parida, Laxmi, Juric, Dejan, Getz, Gad, Corcoran, Ryan B.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Abstract 37: Convergence of resistance patterns in breast cancer after multiple lines of treatment through analysis of rapid autopsy samples by Leshchiner, Ignaty, Martin, Elizabeth E., Chen, Christopher T., Leshchiner, Elizaveta, Zhang, Thomas, Pinto, Christopher, Utro, Filippo, Rhrissorrakrai, Kahn, Levovitz, Chaya, Danysh, Brian P., Slowik, Kara, Jacobs, Raquel A., Parida, Laxmi, Getz, Gad, Juric, Dejan

“…Abstract Determining patterns and mechanisms of drug resistance is fundamentally required for improving clinical outcome of cancer treatments. The ability to…”
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Abstract LB449: Strategies to overcome resistance to PI3Kalpha-selective inhibitors mediated by acquired alterations in the PI3K/AKT pathway by Cruz, Ferran Fece de la, Varkaris, Andreas, Martin, Elizabeth E., Norden, Bryanna L., Chevalier, Nicholas, Kehlmann, Allison M., Leshchiner, Ignaty, Barnes, Haley, Ehnstrom, Sara, Patel, Parasvi, Kim, Janice S., Ellis, Haley, Sanidas, Ioannis, Lau, Kayao T., Bardia, Aditya, Spring, Laura M., Isakoff, Steven J., Lennerz, Jochen K., Getz, Gad, Corcoran, Ryan B., Juric, Dejan

“…Abstract PIK3CA is among the most frequently mutated kinases in multiple types of cancer, including in 40% of hormone receptor-positive, HER2-negative breast…”
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Renal Cell Carcinoma With TFEB Translocation Versus Unclassified Renal Cell Carcinoma With TFEB Amplification by Martin, Elizabeth E., Mehra, Rohit, Jackson-Cook, Colleen, Smith, Steven Christopher

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Abstract 1789: Chromatin modifier alterations confer resistance to endocrine deprivation and CDK4/6 inhibitors in ER+ breast cancer and drive convergent evolution in patient autopsy lesions by Leshchiner, Elizaveta, Leshchiner, Ignaty, Martin, Elizabeth E., Chen, Christopher T., Zhang, Thomas, Pinto, Christopher, Rhrissorrakrai, Kahn, Utro, Filippo, Levovitz, Chaya, Jacobs, Raquel A., Danysh, Brian P., Slowik, Kara, Broudo, Maida, Parida, Laxmi, Juric, Dejan, Getz, Gad

“…Abstract We studied resistance mechanisms to hormone therapy and CDK4/6 cell cycle inhibitors in ER+ breast cancer by analyzing whole-exome, whole-genome,…”
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Abstract 5162: TuFEst: a sensitive and cost-effective pan-cancer detection approach with accurate tumor fraction estimation by Lin, Ziao, Stewart, Chip, Martin, Elizabeth E., Danysh, Brian P., Jacobs, Raquel A., Slowik, Kara, Lawton, Lee, Lightbody, Elizabeth, Rhrissorrakrai, Kahn, Utro, Filippo, Levovitz, Chaya, Cibulskis, Carrie, Ghobrial, Irene M., Shipp, Margaret, Corcoran, Ryan B., Juric, Dejan, Parida, Laxmi, Parsons, Heather A., Getz, Gad

“…Abstract Detecting cancer at early stages or upon recurrence is critical to decreasing cancer morbidity and mortality. We developed TuFEst (Tumor Fraction…”
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Advance care planning: Beyond the living will by Messinger-Rapport, Barbara J, Baum, Elizabeth E, Smith, Martin L

“…For a variety of reasons, the most commonly used advance directive documents (eg, the living will) may not be very useful in many situations that older adults…”
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Laser capture microdissection and genetic analysis of carbon-labeled Kupffer cells by Gehring, Stephan, Sabo, Edmond, San Martin, Maryann E, Dickson, Elizabeth M, Cheng, Chao-Wen, Gregory, Stephen H

“…AIM： To develop a method of labeling and microdissecting mouse Kupffer cells within an extraordinarily short period of time using laser capture microdissection…”
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