Search Results - "Martin, David A"

Jalview Version 2—a multiple sequence alignment editor and analysis workbench by Waterhouse, Andrew M., Procter, James B., Martin, David M. A., Clamp, Michèle, Barton, Geoffrey J.

“…Jalview Version 2 is a system for interactive WYSIWYG editing, analysis and annotation of multiple sequence alignments. Core features include keyboard and…”
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The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses by Lowes, Michelle A, Russell, Chris B, Martin, David A, Towne, Jennifer E, Krueger, James G

“…Psoriasis is a complex inflammatory process resulting from activation of the well-defined interleukin (IL)-23/T17 cytokine axis. We review the role of key…”
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The Emerging Role of IL-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings by Martin, David A., Towne, Jennifer E., Kricorian, Gregory, Klekotka, Paul, Gudjonsson, Johann E., Krueger, James G., Russell, Chris B.

“…Although the histological changes seen in psoriasis have long been well characterized, the underlying cellular and molecular mechanisms have only begun to be…”
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After 25 years of drug development, do we know JAK? by Mortezavi, Mahta, Martin, David A, Schulze-Koops, Hendrik

“…Additional genetic mutations in JAK2 (activating) and tyrosine kinase 2 (TYK2; inactivating) were also found to be associated with immune phenotypes amenable…”
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Psychedelics Recruit Multiple Cellular Types and Produce Complex Transcriptional Responses Within the Brain by Martin, David A., Nichols, Charles D.

“…There has recently been a resurgence of interest in psychedelics, substances that profoundly alter perception and cognition and have recently demonstrated…”
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Dopamine in the dorsal bed nucleus of stria terminalis signals Pavlovian sign-tracking and reward violations by Gyawali, Utsav, Martin, David A, Sun, Fangmiao, Li, Yulong, Calu, Donna

“…Midbrain and striatal dopamine signals have been extremely well characterized over the past several decades, yet novel dopamine signals and functions in reward…”
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A Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis by Cohen, Stanley, Beebe, Jean S, Chindalore, Vishala, Guan, Shunjie, Hassan-Zahraee, Mina, Saxena, Madhurima, Xi, Li, Hyde, Craig, Koride, Sarita, Levin, Robert, Lubaczewski, Shannon, Salganik, Mikhail, Sloan, Abigail, Stevens, Erin, Peeva, Elena, Vincent, Michael S, Martin, David A, Chu, Myron

“…The objective of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑06835375, a potent selective afucosyl…”
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Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition by Dowty, Martin E., Lin, Tsung H., Jesson, Michael I., Hegen, Martin, Martin, David A., Katkade, Vaibhav, Menon, Sujatha, Telliez, Jean‐Baptiste

“…Janus kinase (JAK) inhibitors have emerged as an effective class of therapies for various inflammatory diseases such as rheumatoid arthritis (RA). JAK…”
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A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis by Martin, David A, Churchill, Melvin, Flores-Suarez, Luis, Cardiel, Mario H, Wallace, Daniel, Martin, Richard, Phillips, Kristine, Kaine, Jeffrey L, Dong, Hua, Salinger, David, Stevens, Erin, Russell, Chris B, Chung, James B

“…The aim of this study was to evaluate the safety, pharmacokinetics, and clinical response of brodalumab (AMG 827), a human, anti-IL-17 receptor A (IL-17RA)…”
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Role of BNST CRFR1 Receptors in Incubation of Fentanyl Seeking by Gyawali, Utsav, Martin, David A., Sulima, Agnieszka, Rice, Kenner C., Calu, Donna J.

“…The time-dependent increase in cue-triggered opioid seeking, termed “incubation of opioid craving,” is modeled in rodents by examining responding for…”
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Practical needle selection for Vienna-style applicators: improving therapeutic ratio in hybrid intracavitary-interstitial brachytherapy by Martin, David A, Taunk, Neil K, Anamalayil, Shibu, Mangal, Vatsal, Marcel, Jaclyn, Hubley, Emily

“…Hybrid intracavitary and interstitial (IC/IS) applicators improve dose distribution compared to traditional IC applicators in cervical high-dose-rate (HDR)…”
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Effects of angiotensin-neprilysin inhibition compared to angiotensin inhibition on ventricular arrhythmias in reduced ejection fraction patients under continuous remote monitoring of implantable defibrillator devices by de Diego, Carlos, González-Torres, Luis, Núñez, José María, Centurión Inda, Raúl, Martin-Langerwerf, David A., Sangio, Antonio D., Chochowski, Piotr, Casasnovas, Pilar, Blazquéz, Julio C., Almendral, Jesús

“…Angiotensin-neprilysin inhibition compared to angiotensin inhibition decreased sudden cardiac death in patients with reduced ejection fraction heart failure…”
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Corrigendum: Role of BNST CRFR1 Receptors in Incubation of Fentanyl Seeking by Gyawali, Utsav, Martin, David A., Sulima, Agnieszka, Rice, Kenner C., Calu, Donna J.

“…(B) Change in body weight across days for opioid-dependent and non-dependent rats after start of dependence phase. [...]it provided us with a deeper…”
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Biomarkers to predict risk of venous thromboembolism in patients with rheumatoid arthritis receiving tofacitinib or tumour necrosis factor inhibitors by Weitz, Jeffrey I, Szekanecz, Zoltán, Charles-Schoeman, Christina, Vranic, Ivana, Sahin, Burak, Paciga, Sara A, Wang, Zhenyu, Hyde, Craig, Martin, David A

“…ObjectiveIn the ORAL (Oral Rheumatoid Arthritis triaL) Surveillance study of patients with rheumatoid arthritis aged ≥50 years with ≥1 additional…”
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Point-of-Care Ultrasound Diagnosis of Tetralogy of Fallot Causing Cyanosis: A Case Report by Addepalli, Aravind, Guillen, Marco, Dreyfuss, Andrea, Mantuani, Daniel, Nagdev, Arun, Martin, David A

“…Tetralogy of Fallot (TOF) is a congenital heart defect with characteristic features leading to unique physical exam and ultrasound findings. In settings where…”
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A Novel Multimodal Approach to Point-of-Care Ultrasound Education in Low-Resource Settings by Dreyfuss, Andrea, Martin, David A, Farro, Angel, Inga, Robert, Enríquez, Sayuri, Mantuani, Daniel, Nagdev, Arun

“…Point-of-care ultrasound (POCUS) enables physicians to make critical diagnosis and treatment decisions at the bedside. However, access to and expertise with…”
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Role of Tele-ultrasound for Teaching Ultrasound-guided Nerve Blocks in the Emergency Department: A Case Series from Peru by Martin, David, Guillen, Marco, Farro, Angel, Condori, Maribel, Dreyfuss, Andrea, Nagdev, Arun

“…Introduction: Ultrasound-guided nerve blocks (UGNB) represent a procedural skill set that can be used to treat acute pain by physicians in the emergency…”
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Primary school students' perceptions and developed artefacts and language from learning coding and computational thinking using the 3C model by Martin, David A., Curtis, Peter, Redmond, Petrea

“…Background A resurgence in teaching coding in primary school classrooms has led to a pedagogical swing towards using physical computing and coding to develop…”
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Global Quantitative SILAC Phosphoproteomics Reveals Differential Phosphorylation Is Widespread between the Procyclic and Bloodstream Form Lifecycle Stages of Trypanosoma brucei by Urbaniak, Michael D, Martin, David M. A, Ferguson, Michael A. J

“…We report a global quantitative phosphoproteomic study of bloodstream and procyclic form Trypanosoma brucei using SILAC labeling of each lifecycle stage…”
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Ultrasound-Guided Nerve Blocks by Martin, David A., Ashworth, Henry, Nagdev, Arun

“…Ultrasound-guided nerve blocks serve as a valuable component of multimodal pain management for acutely injured patients in the emergency department and offer a…”
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