Search Results - "Martin, Darren S. D."

The effect of retinol binding protein on the proteome of C2C12 muscle cells by Young, Pamela A., Leonard, Siobhán, Martin, Darren S. D., Findlay, John B. C.

“…Background Retinol binding protein (RBP) and its membrane receptor, STRA6, are vital for the management of vitamin A in the body. Recently, elevated serum RBP…”
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Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide‐induced dysfunction in rat hippocampus by Lonergan, Peter E., Martin, Darren S. D., Horrobin, David F., Lynch, Marina A.

“…Eicosapentaenoic acid (EPA) protects hippocampus from age‐related and irradiation‐induced changes that lead to impairment in synaptic function; the evidence…”
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Analysis of the effect of a novel therapeutic for type 2 diabetes on the proteome of a muscle cell line by Young, Pamela A., Leonard, Siobhán, Martin, Darren S. D., Findlay, John B. C.

“…Elevated serum retinol‐binding protein (RBP) concentration has been implicated in the development of insulin resistance and type 2 diabetes. Two series of…”
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The deficit in long-term potentiation induced by chronic administration of amyloid-β is attenuated by treatment of rats with a novel phospholipid-based drug formulation, VP025 by Miller, Anne-Marie, Piazza, Alessia, Martin, Darren S.D., Walsh, Michelle, Mandel, Arkady, Bolton, Anthony E., Lynch, Marina A.

“…Amyloid-β (Aβ) peptides, the primary component of the amyloid plaques in Alzheimer’s disease (AD), exert profound effects on neurons in vitro and negatively…”
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Novel mitochondrial complex I inhibitors restore glucose-handling abilities of high-fat fed mice by Martin, Darren S D, Leonard, Siobhán, Devine, Robert, Redondo, Clara, Kinsella, Gemma K, Breen, Conor J, McEneaney, Victoria, Rooney, Mary F, Munsey, Tim S, Porter, Richard K, Sivaprasadarao, Asipu, Stephens, John C, Findlay, John B C

“…Metformin is the main drug of choice for treating type 2 diabetes, yet the therapeutic regimens and side effects of the compound are all undesirable and can…”
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A novel phospholipid-based drug formulation, VP025, modulates age- and LPS-induced microglial activity in the rat by Martin, Darren S D, Walsh, Michelle, Miller, Anne-Marie, Skerrett, Helen E, Byrne, Patricia, Mandel, Arkady, Bolton, Anthony E, Lynch, Marina A

“…A common change that occurs with age in the central nervous system is an increase in microglial-associated inflammation. This is usually coupled with an…”
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Neuroprotective Effect of Eicosapentaenoic Acid in Hippocampus of Rats Exposed to γ-Irradiation by Lonergan, Peter E., Martin, Darren S.D., Horrobin, David F., Lynch, Marina A.

“…Exposure to irradiation leads to detrimental changes in several cell types. In this study we assessed the changes induced in hippocampus by exposure of rats to…”
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Neuroprotective Effect of Eicosapentaenoic Acid in Hippocampus of Rats Exposed to γ-Irradiation by Peter E. Lonergan, Darren S. D. Martin, David F. Horrobin, Marina A. Lynch

“…Exposure to irradiation leads to detrimental changes in several cell types. In this study we assessed the changes induced in hippocampus by exposure of rats to…”
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Apoptotic Changes in the Aged Brain Are Triggered by Interleukin-1β-induced Activation of p38 and Reversed by Treatment with Eicosapentaenoic Acid by Darren S. D. Martin, Peter E. Lonergan, Barry Boland, Marie P. Fogarty, Marcella Brady, David F. Horrobin, Veronica A. Campbell, Marina A. Lynch

“…Among the several changes that occur in the aged brain is an increase in the concentration of the proinflammatory cytokine interleukin-1β that is coupled with…”
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Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid by Martin, Darren S D, Lonergan, Peter E, Boland, Barry, Fogarty, Marie P, Brady, Marcella, Horrobin, David F, Campbell, Veronica A, Lynch, Marina A

“…Among the several changes that occur in the aged brain is an increase in the concentration of the proinflammatory cytokine interleukin-1beta that is coupled…”
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