Search Results - "Martin, Dale"

Autophagy in Huntington disease and huntingtin in autophagy by Martin, Dale D.O, Ladha, Safia, Ehrnhoefer, Dagmar E, Hayden, Michael R

“…Highlights • HTT is an important regulator of autophagy that is, in turn, degraded by autophagy. • Genes regulating protein clearance show altered expression…”
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Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers by Sanders, Shaun S, Martin, Dale D O, Butland, Stefanie L, Lavallée-Adam, Mathieu, Calzolari, Diego, Kay, Chris, Yates, 3rd, John R, Hayden, Michael R

“…Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent…”
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Post-translational myristoylation: Fat matters in cellular life and death by Martin, Dale D.O., Beauchamp, Erwan, Berthiaume, Luc G.

“…Myristoylation corresponds to the irreversible covalent linkage of the 14-carbon saturated fatty acid, myristic acid, to the N-terminal glycine of many…”
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Let's get fat: emergence of S-acylation as a therapeutic target in Huntington disease by Martin, Dale D O, Sanders, Shaun S

“…Protein mislocalization is a key initial step in neurodegeneration, regardless of etiology, and has been linked to changes in the dynamic addition of saturated…”
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The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity by Bhavsar, Amit P, Brown, Nat F, Stoepel, Jan, Wiermer, Marcel, Martin, Dale D O, Hsu, Karolynn J, Imami, Koshi, Ross, Colin J, Hayden, Michael R, Foster, Leonard J, Li, Xin, Hieter, Phil, Finlay, B Brett

“…To further its pathogenesis, S. Typhimurium delivers effector proteins into host cells, including the novel E3 ubiquitin ligase (NEL) effector SspH2. Using…”
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Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders by Wlodarczyk, Jakub, Bhattacharyya, Raja, Dore, Kim, Ho, Gary P H, Martin, Dale D O, Mejias, Rebeca, Hochrainer, Karin

“…Palmitoylation, a lipid-based posttranslational protein modification, plays a crucial role in regulating various aspects of neuronal function through altering…”
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Identification of Novel Inhibitors of DLK Palmitoylation and Signaling by High Content Screening by Martin, Dale D. O., Kanuparthi, Prasad S., Holland, Sabrina M., Sanders, Shaun S., Jeong, Hey-Kyeong, Einarson, Margret B., Jacobson, Marlene A., Thomas, Gareth M.

“…After axonal insult and injury, Dual leucine-zipper kinase (DLK) conveys retrograde pro-degenerative signals to neuronal cell bodies via its downstream target…”
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Lost in traffic: consequences of altered palmitoylation in neurodegeneration by Ramzan, Firyal, Abrar, Fatima, Mishra, Gyana Gourab, Liao, Lucia Meng Qi, Martin, Dale D O

“…One of the first molecular events in neurodegenerative diseases, regardless of etiology, is protein mislocalization. Protein mislocalization in neurons is…”
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Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks by Aly, Amirah E.-E., Caron, Nicholas S., Black, Hailey Findlay, Schmidt, Mandi E., Anderson, Christine, Ko, Seunghyun, Baddeley, Helen J.E., Anderson, Lisa, Casal, Lorenzo L., Rahavi, Reza S.M., Martin, Dale D.O., Hayden, Michael R.

“…Lowering mutant huntingtin (mHTT) in the central nervous system (CNS) using antisense oligonucleotides (ASOs) is a promising approach currently being evaluated…”
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Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin by Martin, Dale D O, Heit, Ryan J, Yap, Megan C, Davidson, Michael W, Hayden, Michael R, Berthiaume, Luc G

“…Huntington disease (HD) is a debilitating neurodegenerative disease characterized by the loss of motor control and cognitive ability that ultimately leads to…”
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Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection by Embers, Monica E, Barthold, Stephen W, Borda, Juan T, Bowers, Lisa, Doyle, Lara, Hodzic, Emir, Jacobs, Mary B, Hasenkampf, Nicole R, Martin, Dale S, Narasimhan, Sukanya, Phillippi-Falkenstein, Kathrine M, Purcell, Jeanette E, Ratterree, Marion S, Philipp, Mario T

“…The persistence of symptoms in Lyme disease patients following antibiotic therapy, and their causes, continue to be a matter of intense controversy. The…”
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Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity by Lemarié, Fanny L., Caron, Nicholas S., Sanders, Shaun S., Schmidt, Mandi E., Nguyen, Yen T.N., Ko, Seunghyun, Xu, Xiaohong, Pouladi, Mahmoud A., Martin, Dale D.O., Hayden, Michael R.

“…Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene that codes for an elongated polyglutamine tract in the…”
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Protective Proteolysis in Huntington's Disease: Unraveling the Role of Post-Translational Myristoylation of Huntingtin in Autophagy by Alshehabi, Yasmeen, Martin, Dale D O

“… Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by impaired motor function and cognitive decline, ultimately leading to…”
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Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance by Martin, Dale D. O., Schmidt, Mandi E., Nguyen, Yen T., Lazic, Nikola, Hayden, Michael R.

“…ABSTRACT Huntington disease (HD) is a progressive neurodegenerative disease that initially affects the striatum and leads to changes in behavior and loss of…”
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Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice by Wong, Bibiana K.Y, Ehrnhoefer, Dagmar E, Graham, Rona K, Martin, Dale D.O, Ladha, Safia, Uribe, Valeria, Stanek, Lisa M, Franciosi, Sonia, Qiu, Xiaofan, Deng, Yu, Kovalik, Vlad, Zhang, Weining, Pouladi, Mahmoud A, Shihabuddin, Lamya S, Hayden, Michael R

“…Abstract Huntington Disease (HD) is a progressive neurodegenerative disease caused by an elongated CAG repeat in the huntingtin ( HTT ) gene that encodes a…”
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Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage by Lemarié, Fanny L, Sanders, Shaun S, Nguyen, Yen, Martin, Dale D O, Hayden, Michael R

“…Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated…”
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Neurodegeneration: Role of repeats in protein clearance by Martin, Dale D O, Hayden, Michael R

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Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease by Caron, Nicholas S., Aly, Amirah E.-E., Findlay Black, Hailey, Martin, Dale D.O., Schmidt, Mandi E., Ko, Seunghyun, Anderson, Christine, Harvey, Emily M., Casal, Lorenzo L., Anderson, Lisa M., Rahavi, Seyed M.R., Reid, Gregor S.D., Oda, Michael N., Stanimirovic, Danica, Abulrob, Abedelnasser, McBride, Jodi L., Leavitt, Blair R., Hayden, Michael R.

“…Efficient delivery of therapeutics to the central nervous system (CNS) remains a major challenge for the treatment of neurological diseases. Huntington disease…”
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Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry[S] by Yap, Megan C., Kostiuk, Morris A., Martin, Dale D.O., Perinpanayagam, Maneka A., Hak, Pieter G., Siddam, Anjaiah, Majjigapu, Janaki R., Rajaiah, Gurram, Keller, Bernd O., Prescher, Jennifer A., Wu, Peng, Bertozzi, Carolyn R., Falck, John R., Berthiaume, Luc G.

“…Progress in understanding the biology of protein fatty acylation has been impeded by the lack of rapid direct detection and identification methods. We first…”
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Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration by Martin, Dale D O, Hayden, Michael R

“…In a little more than a decade, post-translational myristoylation (PTMyr) has become an established post-translational modification during cell death. It…”
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