Search Results - "Martin, Brian K."

Safety and immunogenicity of the rVSV∆G-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind, placebo-controlled, dose-response study by Heppner, D Gray, Dr, Kemp, Tracy L, MPH, Martin, Brian K, PhD, Ramsey, William J, MD, Nichols, Richard, MA, Dasen, Emily J, BA, Link, Charles J, MD, Das, Rituparna, MD, Xu, Zhi Jin, PhD, Sheldon, Eric A, MD, Nowak, Teresa A, BSE, Monath, Thomas P, MD

“…Summary Background The 2014 Zaire Ebola virus outbreak highlighted the need for a safe, effective vaccine with a rapid onset of protection. We report the…”
Get full text

rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/benefit assessment by Monath, Thomas P, Fast, Patricia E, Modjarrad, Kayvon, Clarke, David K, Martin, Brian K, Fusco, Joan, Nichols, Richard, Heppner, D Gray, Simon, Jakub K, Dubey, Sheri, Troth, Sean P, Wolf, Jayanthi, Singh, Vidisha, Coller, Beth-Ann, Robertson, James S

“…The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety and characteristics of live, recombinant viral…”
Get full text

Addition of αGal HyperAcute™ technology to recombinant avian influenza vaccines induces strong low-dose antibody responses by Chen, Wenlan Alex, Zhang, Jinjin, Hall, Katie M, Martin, Carol B, Kisselev, Serguei, Dasen, Emily J, Vahanian, Nicholas N, Link, Charles J, Martin, Brian K

“…Highly pathogenic avian influenza represents a severe public health threat. Over the last decade, the demand for highly efficacious vaccines against avian…”
Get full text

Transcriptional control of genes for soluble complement cascade regulatory proteins by Fraczek, Laura A, Martin, Brian K

“…The complement cascade of the immune system is an important mediator of the inflammatory response to infection; however it is crucial that this pathway is…”
Get full text

High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission by Morozov, Igor, Monath, Thomas P., Meekins, David A., Trujillo, Jessie D., Sunwoo, Sun-Young, Urbaniak, Kinga, Kim, In Joong, Narayanan, Sanjeev K., Indran, Sabarish V., Ma, Wenjun, Wilson, William C., O'Connor, Cassandra, Dubey, Sheri, Troth, Sean P., Coller, Beth-Ann, Nichols, Richard, Martin, Brian K., Feldmann, Heinz, Richt, Juergen A.

“…The recent impact of Ebola virus disease (EVD) on public health in Africa clearly demonstrates the need for a safe and efficacious vaccine to control outbreaks…”
Get full text

Major Histocompatibility Complex Class II-Transfected Tumor Cells Present Endogenous Antigen and are Potent Inducers of Tumor-Specific Immunity by Armstrong, Tood D., Clements, Virginia K., Martin, Brian K., Jenny P.-Y. Ting, Ostrand-Rosenberg, Suzanne

“…We have developed an immunotherapy in which tumor cells transfected with syngeneic major histocompatibility complex (MHC) class II genes are cell-based…”
Get full text

Comparative evaluation of pathogenicity of three isolates of vesicular stomatitis virus (Indiana serotype) in pigs by Morozov, Igor, Davis, A Sally, Ellsworth, Steven, Trujillo, Jessie D, McDowell, Chester, Shivanna, Vinay, Dasen, Emily J, Nichols, Richard, Martin, Brian K, Monath, Thomas P, Richt, Jurgen A

“…Vesicular stomatitis (VS) is a notifiable disease of livestock affecting cattle, horses, pigs and humans. Vesicular stomatitis virus (VSV) serotypes Indiana…”
Get full text

Transcriptional regulation of the murine C5a receptor gene: NF-Y is required for basal and LPS induced expression in macrophages and endothelial cells by Hunt, Jason R., Martin, Carol B., Martin, Brian K.

“…The anaphylatoxin receptors of the complement system are important in immune defense but also play a role in autoimmune disease. Reports have demonstrated…”
Get full text

A replication-incompetent Rift Valley fever vaccine: Chimeric virus-like particles protect mice and rats against lethal challenge by Mandell, Robert B, Koukuntla, Ramesh, Mogler, Laura J.K, Carzoli, Andrea K, Freiberg, Alexander N, Holbrook, Michael R, Martin, Brian K, Staplin, William R, Vahanian, Nicholas N, Link, Charles J, Flick, Ramon

“…Abstract Virus-like particles (VLPs) present viral antigens in a native conformation and are effectively recognized by the immune system and therefore are…”
Get full text

CNS-specific expression of C3a and C5a exacerbate demyelination severity in the cuprizone model by Ingersoll, Sarah A., Martin, Carol B., Barnum, Scott R., Martin, Brian K.

“…Demyelination in the central nervous system (CNS) is known to involve several immune effector mechanisms, including complement proteins. Local production of…”
Get full text

c-Jun and c-Fos regulate the complement factor H promoter in murine astrocytes by Fraczek, Laura A., Martin, Carol B., Martin, Brian K.

“…► Complement factor H mRNA and protein are expressed in glial cells. ► Novel transcription start sites for factor H in glia and liver cells are reported. ► Its…”
Get full text

Transcriptional control of complement receptor gene expression by Martin, Brian K

“…Immune complement is a critical system in the immune response and protection of host cells from damage by complement is critical during inflammation. The…”
Get full text

Novel suspension cell-based vaccine production systems for Rift Valley fever virus-like particles by Mandell, Robert B., Koukuntla, Ramesh, Mogler, Laura J.K., Carzoli, Andrea K., Holbrook, Michael R., Martin, Brian K., Vahanian, Nicholas, Link, Charles J., Flick, Ramon

“…Rift Valley fever virus (RVFV) is an arthropod-borne pathogen that often results in severe morbidity and mortality in both humans and livestock. As its…”
Get full text

Characterization of the Murine C3a Receptor Enhancer-Promoter: Expression Control by an Activator Protein 1 Sequence and an Ets-Like Site by Martin, Carol B, Martin, Brian K

“…The complement anaphylatoxins, C3a and C5a, exert their effects by binding to their respective receptors. A number of studies have implicated these proteins in…”
Get full text

Induction of MHC Class I Expression by the MHC Class II Transactivator CIITA by Martin, Brian K, Chin, Keh-Chuang, Olsen, John C, Skinner, Cheryl A, Dey, Anup, Ozato, Keiko, Ting, Jenny P.-Y

“…Major histocompatibility complex (MHC) class I–deficient cell lines were used to demonstrate that the MHC class II transactivator ( CIITA) can induce surface…”
Get full text

Transcriptional control of the C3a receptor gene in glial cells: Dependence upon AP-1 but not Ets by Martin, Carol B., Ingersoll, Sarah A., Martin, Brian K.

“…The C3a anaphylatoxin has been implicated in several autoimmune states including arthritis and multiple sclerosis. The expression pattern of the C3a receptor…”
Get full text

Two Distinct Domains within CIITA Mediate Self-Association: Involvement of the GTP-Binding and Leucine-Rich Repeat Domains by Linhoff, Michael W., Harton, Jonathan A., Cressman, Drew E., Martin, Brian K., Ting, Jenny Pan-Yun

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Astrocyte-specific expression of a soluble form of the murine complement control protein Crry confers demyelination protection in the cuprizone model by Briggs, Dustin T., Martin, Carol B., Ingersoll, Sarah A., Barnum, Scott R., Martin, Brian K.

“…Complement has been implicated as a potential effector mechanism in neurodegeneration; yet the precise role of complement in this process remains elusive. In…”
Get full text

Regulation of the C5a receptor promoter in glial cells: Minimal dependence upon the CCAAT element in astrocytes by Martin, Carol B., Ingersoll, Sarah A., Martin, Brian K.

“…The cleavage product of C5, C5a, is an important anaphylatoxin. This inflammatory mediator exerts its effects by binding to the C5a receptor (C5aR, CD88), a…”
Get full text

Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis by Reiman, Rachael, Torres, Antonio Campos, Martin, Brian K., Ting, Jenny P., Campbell, Iain L., Barnum, Scott R.

“…Complement is implicated in the pathology of neurodegenerative and inflammatory disease in the central nervous system (CNS). Although studies demonstrate that…”
Get full text