Search Results - "Martens, John W"

Pan-cancer landscape of homologous recombination deficiency by Nguyen, Luan, W. M. Martens, John, Van Hoeck, Arne, Cuppen, Edwin

“…Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a…”
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Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer by Hammerl, Dora, Martens, John W. M., Timmermans, Mieke, Smid, Marcel, Trapman-Jansen, Anita M., Foekens, Renée, Isaeva, Olga I., Voorwerk, Leonie, Balcioglu, Hayri E., Wijers, Rebecca, Nederlof, Iris, Salgado, Roberto, Horlings, Hugo, Kok, Marleen, Debets, Reno

“…Only a subgroup of triple-negative breast cancer (TNBC) responds to immune checkpoint inhibitors (ICI). To better understand lack of response to ICI, we…”
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Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression by Ren, Jiang, Smid, Marcel, Iaria, Josephine, Salvatori, Daniela C F, van Dam, Hans, Zhu, Hong Jian, Martens, John W M, Ten Dijke, Peter

“…Bone morphogenetic proteins (BMPs) have been reported to maintain epithelial integrity and to antagonize the transforming growth factor β (TGFβ)-induced…”
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A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains most co-occurrence by Canisius, Sander, Martens, John W M, Wessels, Lodewyk F A

“…In cancer, mutually exclusive or co-occurring somatic alterations across genes can suggest functional interactions. Existing tests for such patterns make the…”
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Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression by He, Jichao, McLaughlin, Ronan P., van der Beek, Lambert, Canisius, Sander, Wessels, Lodewyk, Smid, Marcel, Martens, John W. M., Foekens, John A., Zhang, Yinghui, van de Water, Bob

“…The genetically heterogeneous triple-negative breast cancer (TNBC) continues to be an intractable disease, due to lack of effective targeted therapies. Gene…”
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A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy by McLaughlin, Ronan P, He, Jichao, van der Noord, Vera E, Redel, Jevin, Foekens, John A, Martens, John W M, Smid, Marcel, Zhang, Yinghui, van de Water, Bob

“…The effective treatment of triple-negative breast cancer (TNBC) remains a profound clinical challenge. Despite frequent epidermal growth factor receptor (EGFR)…”
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Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features by Mendelaar, Pauline A. J., Smid, Marcel, van Riet, Job, Angus, Lindsay, Labots, Mariette, Steeghs, Neeltje, Hendriks, Mathijs P., Cirkel, Geert A., van Rooijen, Johan M., Ten Tije, Albert J., Lolkema, Martijn P., Cuppen, Edwin, Sleijfer, Stefan, Martens, John W. M., Wilting, Saskia M.

“…In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of metastasized CRC. Here we present whole genome sequencing data of…”
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Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells by Sieuwerts, Anieta M., Kraan, Jaco, Bolt, Joan, van der Spoel, Petra, Elstrodt, Fons, Schutte, Mieke, Martens, John W. M., Gratama, Jan-Willem, Sleijfer, Stefan, Foekens, John A.

“…Identification of specific subtypes of circulating tumor cells in peripheral blood of cancer patients can provide information about the biology of metastasis…”
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5-Fluorouracil treatment induces characteristic T>G mutations in human cancer by Christensen, Sharon, Van der Roest, Bastiaan, Besselink, Nicolle, Janssen, Roel, Boymans, Sander, Martens, John W. M., Yaspo, Marie-Laure, Priestley, Peter, Kuijk, Ewart, Cuppen, Edwin, Van Hoeck, Arne

“…5-Fluorouracil (5-FU) is a chemotherapeutic drug commonly used for the treatment of solid cancers. It is proposed that 5-FU interferes with nucleotide…”
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Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer by He, Jichao, McLaughlin, Ronan P., van der Noord, Vera, Foekens, John A., Martens, John W. M., van Westen, Gerard, Zhang, Yinghui, van de Water, Bob

“…Purpose Owing to its genetic heterogeneity and acquired resistance, triple-negative breast cancer (TNBC) is not responsive to single-targeted therapy, causing…”
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Molecular characterization of circulating tumor cells in large quantities of contaminating leukocytes by a multiplex real-time PCR by Sieuwerts, Anieta M, Kraan, Jaco, Bolt-de Vries, Joan, van der Spoel, Petra, Mostert, Bianca, Martens, John W. M, Gratama, Jan-Willem, Sleijfer, Stefan, Foekens, John A

“…Detection of circulating tumor cells (CTCs) in whole blood from metastatic cancer patients by the CellSearch™ CTC Test (Veridex LLC, Warren, NJ, USA) has been…”
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Integrative whole-genome and transcriptome analysis of HER2-amplified metastatic breast cancer by Verschoor, Noortje, Smid, Marcel, Jager, Agnes, Sleijfer, Stefan, Wilting, Saskia M, Martens, John W. M

“…Abstract Background In breast cancer, the advent of anti-HER2 therapies has made HER2+ tumors a highly relevant subgroup. However, the exact characteristics…”
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Complex landscapes of somatic rearrangement in human breast cancer genomes by Lau, King Wai, Mudie, Laura J, Churcher, Carol, Stratton, Michael R, Silver, Daniel P, van 't Veer, Laura, Børresen-Dale, Anne-Lise, Stebbings, Lucy A, McBride, David J, Martens, John W. M, Simpson, Jared T, Leroy, Catherine, Russnes, Hege E. G, Latimer, Calli, Jia, Mingming, Edkins, Sarah, Natrajan, Rachael, Reis-Filho, Jorge S, Varela, Ignacio, Swerdlow, Harold, Lin, Meng-Lay, Richardson, Andrea L, Pleasance, Erin D, Sieuwerts, Anieta M, Stephens, Philip J, Futreal, P. Andrew, Greenman, Chris D, Burton, John, Langerød, Anita, Quail, Michael A, Foekens, John A, Campbell, Peter J, Teague, Jon W

“…Multiple somatic rearrangements are often found in cancer genomes; however, the underlying processes of rearrangement and their contribution to cancer…”
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MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer by Rodríguez-González, F. Germán, Sieuwerts, Anieta M., Smid, Marcel, Look, Maxime P., Meijer-van Gelder, Marion E., de Weerd, Vanja, Sleijfer, Stefan, Martens, John W. M., Foekens, John A.

“…MicroRNAs (miRNAs) are small RNA molecules that modulate gene expression and which have been implicated in cancer. We evaluated whether five candidate…”
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HER2-low breast cancer shows a lower immune response compared to HER2-negative cases by van den Ende, Nadine S., Smid, Marcel, Timmermans, Annemieke, van Brakel, Johannes B., Hansum, Tim, Foekens, Renée, Trapman, Anita M. A. C., Heemskerk-Gerritsen, Bernadette A. M., Jager, Agnes, Martens, John W. M., van Deurzen, Carolien H. M.

“…Currently, the human epidermal growth factor receptor 2 (HER2) status of breast cancer is classified dichotomously as negative or positive to select patients…”
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SPEN is required for Xist upregulation during initiation of X chromosome inactivation by Robert-Finestra, Teresa, Tan, Beatrice F., Mira-Bontenbal, Hegias, Timmers, Erika, Gontan, Cristina, Merzouk, Sarra, Giaimo, Benedetto Daniele, Dossin, François, van IJcken, Wilfred F. J., Martens, John W. M., Borggrefe, Tilman, Heard, Edith, Gribnau, Joost

“…At initiation of X chromosome inactivation (XCI), Xist is monoallelically upregulated from the future inactive X (Xi) chromosome, overcoming repression by its…”
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Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation by Brinkman, Arie B., Nik-Zainal, Serena, Simmer, Femke, Rodríguez-González, F. Germán, Smid, Marcel, Alexandrov, Ludmil B., Butler, Adam, Martin, Sancha, Davies, Helen, Glodzik, Dominik, Zou, Xueqing, Ramakrishna, Manasa, Staaf, Johan, Ringnér, Markus, Sieuwerts, Anieta, Ferrari, Anthony, Morganella, Sandro, Fleischer, Thomas, Kristensen, Vessela, Gut, Marta, van de Vijver, Marc J., Børresen-Dale, Anne-Lise, Richardson, Andrea L., Thomas, Gilles, Gut, Ivo G., Martens, John W. M., Foekens, John A., Stratton, Michael R., Stunnenberg, Hendrik G.

“…Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially…”
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Steps forward for cancer precision medicine by Salgado, Roberto, Moore, Helen, Martens, John W. M., Lively, Tracy, Malik, Shakun, McDermott, Ultan, Michiels, Stefan, Moscow, Jeffrey A., Tejpar, Sabine, McKee, Tawnya, Lacombe, Denis

“…The availability of targeted anticancer drugs and the relative affordability of genomic analyses has led to a growing expectation among patients with cancer…”
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MicroRNAs as possible indicators of drug sensitivity in breast cancer cell lines by Uhr, Katharina, Prager-van der Smissen, Wendy J C, Heine, Anouk A J, Ozturk, Bahar, van Jaarsveld, Marijn T M, Boersma, Antonius W M, Jager, Agnes, Wiemer, Erik A C, Smid, Marcel, Foekens, John A, Martens, John W M

“…MicroRNAs (miRNAs) regulate gene expression post-transcriptionally. In this way they might influence whether a cell is sensitive or resistant to a certain…”
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Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer by Leon-Ferre, Roberto A, Jonas, Sarah Flora, Salgado, Roberto, Loi, Sherene, de Jong, Vincent, Carter, Jodi M, Nielsen, Torsten O, Leung, Samuel, Riaz, Nazia, Chia, Stephen, Jules-Clément, Gérôme, Curigliano, Giuseppe, Criscitiello, Carmen, Cockenpot, Vincent, Lambertini, Matteo, Suman, Vera J, Linderholm, Barbro, Martens, John W. M, van Deurzen, Carolien H. M, Timmermans, A. Mieke, Shimoi, Tatsunori, Yazaki, Shu, Yoshida, Masayuki, Kim, Sung-Bae, Lee, Hee Jin, Dieci, Maria Vittoria, Bataillon, Guillaume, Vincent-Salomon, Anne, André, Fabrice, Kok, Marleen, Linn, Sabine C, Goetz, Matthew P, Michiels, Stefan

“…IMPORTANCE: The association of tumor-infiltrating lymphocyte (TIL) abundance in breast cancer tissue with cancer recurrence and death in patients with…”
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