Search Results - "Martens, Forike K"

DPD Testing Before Treatment With Fluoropyrimidines in the Amsterdam UMCs: An Evaluation of Current Pharmacogenetic Practice by Martens, Forike K, Huntjens, Daan W, Rigter, Tessel, Bartels, Meike, Bet, Pierre M, Cornel, Martina C

“…The fluoropyrimidines (FP) (5-Fluorouracil, capecitabine, and tegafur) are commonly used anti-cancer drugs, but lead to moderate to severe toxicity in about…”
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Reflection on modern methods: Revisiting the area under the ROC Curve by Janssens, A Cecile J W, Martens, Forike K

“…The area under the receiver operating characteristic (ROC) curve (AUC) is commonly used for assessing the discriminative ability of prediction models even…”
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Evaluation of polygenic risk models using multiple performance measures: a critical assessment of discordant results by Martens, Forike K., Tonk, Elisa C. M., Janssens, A. Cecile J. W.

“…Purpose The area under the receiver operating characteristic curve (AUC) is commonly used for evaluating the improvement of polygenic risk models and…”
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Small improvement in the area under the receiver operating characteristic curve indicated small changes in predicted risks by Martens, Forike K, Tonk, Elisa C.M, Kers, Jannigje G, Janssens, A. Cecile J.W

“…Abstract Objective Adding risk factors to a prediction model often increases the area under the receiver operating characteristic curve (AUC) only slightly,…”
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External validation is only needed when prediction models are worth it (Letter commenting on: J Clin Epidemiol. 2015;68:25-34) by Martens, Forike K, Kers, Jannigje G, Janssens, A. Cecile J.W

“…[...]many of the remaining 41 studies (62 minus 21) that were not externally validated may not have been worth validating…”
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Risk Analysis of Prostate Cancer in PRACTICAL Consortium-Letter by Martens, Forike K, Kers, Jannigje G, Janssens, A Cecile J W

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How the Intended Use of Polygenic Risk Scores Guides the Design and Evaluation of Prediction Studies by Martens, Forike K., Janssens, A. Cecile J.W.

“…Purpose of Review To explain how the intended use of polygenic risk scores (PRSs) in healthcare guides the design and evaluation of prediction studies. Recent…”
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