Search Results - "Martelli, Alberto Maria"

The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma by Lampis, Silvia, Raieli, Salvatore, Montemurro, Luca, Bartolucci, Damiano, Amadesi, Camilla, Bortolotti, Sonia, Angelucci, Silvia, Scardovi, Anna Lisa, Nieddu, Giammario, Cerisoli, Lucia, Paganelli, Francesca, Valente, Sabrina, Fischer, Matthias, Martelli, Alberto Maria, Pasquinelli, Gianandrea, Pession, Andrea, Hrelia, Patrizia, Tonelli, Roberto

“…Neuroblastoma is a deadly childhood cancer, and MYCN-amplified neuroblastoma (MNA-NB) patients have the worst prognoses and are therapy-resistant. While…”
Get full text

Tyrosol prevents apoptosis in irradiated keratinocytes by Salucci, Sara, Burattini, Sabrina, Battistelli, Michela, Buontempo, Francesca, Canonico, Barbara, Martelli, Alberto Maria, Papa, Stefano, Falcieri, Elisabetta

“…Highlights • Tyrosol, present in virgin oil, is a polyphenolic compound with antioxidant properties. • Tyrosol effect has been investigated in keratynocytes in…”
Get full text

Protective effect of different antioxidant agents in UVB-irradiated keratinocytes by Salucci, Sara, Burattini, Sabrina, Buontempo, Francesca, Martelli, Alberto Maria, Falcieri, Elisabetta, Battistelli, Michela

“…Skin cells can respond to UVB-induced damage either by tolerating it, or restoring it through antioxidant activation and DNA repair mechanisms or, ultimately,…”
Get full text

Enhancing radiosensitivity of melanoma cells through very high dose rate pulses released by a plasma focus device by Buontempo, Francesca, Orsini, Ester, Zironi, Isabella, Isolan, Lorenzo, Cappellini, Alessandra, Rapino, Stefania, Tartari, Agostino, Mostacci, Domiziano, Cucchi, Giorgio, Martelli, Alberto Maria, Sumini, Marco, Castellani, Gastone

“…Radiation therapy is a useful and standard tumor treatment strategy. Despite recent advances in delivery of ionizing radiation, survival rates for some cancer…”
Get full text

Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway by Lonetti, Annalisa, Cappellini, Alessandra, Bertaina, Alice, Locatelli, Franco, Pession, Andrea, Buontempo, Francesca, Evangelisti, Camilla, Evangelisti, Cecilia, Orsini, Ester, Zambonin, Laura, Neri, Luca Maria, Martelli, Alberto Maria, Chiarini, Francesca

“…Although in recent years, the introduction of novel chemotherapy protocols has improved the outcome of T cell acute lymphoblastic leukemia (T-ALL) patients,…”
Get full text

Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene by Masetti, Riccardo, Bertuccio, Salvatore Nicola, Astolfi, Annalisa, Chiarini, Francesca, Lonetti, Annalisa, Indio, Valentina, De Luca, Matilde, Bandini, Jessica, Serravalle, Salvatore, Franzoni, Monica, Pigazzi, Martina, Martelli, Alberto Maria, Basso, Giuseppe, Locatelli, Franco, Pession, Andrea

“…CBFA2T3-GLIS2 is a fusion gene found in 17% of non-Down syndrome acute megakaryoblastic leukemia (non-DS AMKL, FAB M7) and in 8% of pediatric cytogenetically…”
Get full text

Nuclear Phospholipase C β1 (PLCβ1) Affects CD24 Expression in Murine Erythroleukemia Cells by Fiume, Roberta, Faenza, Irene, Matteucci, Alessandro, Astolfi, Annalisa, Vitale, Marco, Martelli, Alberto Maria, Cocco, Lucio

“…Inositide-specific phospholipase C (PLC) β1 is a key enzyme in nuclear lipid signal transduction affecting cell cycle progression and may be directly involved…”
Get full text

Nuclear Phospholipase C Signaling Through Type 1 IGF Receptor and its Involvement in Cell Growth and Differentiation by FAENZA, Irene, BILLI, Anna Maria, YUNG FOLLO, Matilde, FIUME, Roberta, MARTELLI, Alberto Maria, COCCO, Lucio, MANZOLI, Lucia

“…The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the…”
Get full text

How to Manage Philadelphia-Positive Acute Lymphoblastic Leukemia in Resource-Constrained Settings by Silva, Wellington, Rego, Eduardo

“…Recent studies have indicated that more than half of adult patients newly diagnosed with Ph+ ALL can now achieve a cure. However, determining the most suitable…”
Get full text

Antioxidants in the prevention of UVB-induced keratynocyte apoptosis by Salucci, Sara, Burattini, Sabrina, Curzi, Davide, Buontempo, Francesca, Martelli, Alberto Maria, Zappia, Giovanni, Falcieri, Elisabetta, Battistelli, Michela

“…•Melatonin, creatine and hydroxytyrosol are known antioxidant compounds.•Their effect on HaCat cells undergoing UVB radiation was studies.•These molecule…”
Get full text

Phosphatidylinositol 3‐kinase inhibition potentiates glucocorticoid response in B‐cell acute lymphoblastic leukemia by Evangelisti, Cecilia, Cappellini, Alessandra, Oliveira, Mariana, Fragoso, Rita, Barata, João T., Bertaina, Alice, Locatelli, Franco, Simioni, Carolina, Neri, Luca M., Chiarini, Francesca, Lonetti, Annalisa, Buontempo, Francesca, Orsini, Ester, Pession, Andrea, Manzoli, Lucia, Martelli, Alberto Maria, Evangelisti, Camilla

“…Despite remarkable progress in polychemotherapy protocols, pediatric B‐cell acute lymphoblastic leukemia (B‐ALL) remains fatal in around 20% of cases. Hence,…”
Get full text

Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB by Buontempo, Francesca, Orsini, Ester, Lonetti, Annalisa, Cappellini, Alessandra, Chiarini, Francesca, Evangelisti, Camilla, Evangelisti, Cecilia, Melchionda, Fraia, Pession, Andrea, Bertaina, Alice, Locatelli, Franco, Bertacchini, Jessika, Neri, Luca Maria, McCubrey, James A, Martelli, Alberto Maria

“…The proteasome inhibitor bortezomib is a new targeted treatment option for refractory or relapsed acute lymphoblastic leukemia (ALL) patients. However, a…”
Get full text

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors by Lonetti, Annalisa, Cappellini, Alessandra, Spartà, Antonino Maria, Chiarini, Francesca, Buontempo, Francesca, Evangelisti, Camilla, Evangelisti, Cecilia, Orsini, Ester, McCubrey, James A, Martelli, Alberto Maria

“…Class I phosphatidylinositol 3-kinases (PI3Ks) are frequently activated in T-cell acute lymphoblastic leukemia (T-ALL), mainly due to the loss of PTEN…”
Get full text

A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer by Pradella, Laura Maria, Evangelisti, Cecilia, Ligorio, Claudia, Ceccarelli, Claudio, Neri, Iria, Zuntini, Roberta, Amato, Laura Benedetta, Ferrari, Simona, Martelli, Alberto Maria, Gasparre, Giuseppe, Turchetti, Daniela

“…An early age at Breast Cancer (BC) onset may be a hallmark of inherited predisposition, but BRCA1/2 mutations are only found in a minority of younger BC…”
Get full text

Nuclear Inositide Signalling: Role of PI‐PLCbeta1 in MDS and AML by Cocco, Lucio, Follo, Matilde Yung, Finelli, Carlo, Mongiorgi, Sara, Faenza, Irene, Fiume, Roberta, Ramazzotti, Giulia, Billi, Anna Maria, Martinelli, Giovanni, Manzoli, Lucia, Martelli, Alberto Maria

“…The nuclear signaling evoked by phosphoinositide‐ specific‐phospholipase C (PI‐PLC)beta1 targets specific regions of Cyclin D3 as well CD24 promoter, hinting…”
Get full text

PKC-ζ expression is lower in osteoblasts from arthritic patients: IL1-β and TNF-α induce a similar decrease in non-arthritic human osteoblasts by Zini, Nicoletta, Bavelloni, Alberto, Lisignoli, Gina, Ghisu, Sonia, Valmori, Aurelio, Martelli, Alberto Maria, Facchini, Andrea, Maraldi, Nadir Mario

“…Protein kinase C (PKC) is a family of enzymes detected in a diverse range of cell types where they regulate various cellular functions such as proliferation,…”
Get full text

Nuclear Phospholipase C beta 1 (PLC beta 1) Affects CD24 Expression in Murine Erythroleukemia Cells by Fiume, Roberta, Faenza, Irene, Matteucci, Alessandro, Astolfi, Annalisa, Vitale, Marco, Martelli, Alberto Maria, Cocco, Lucio

“…Inositide-specific phospholipase C (PLC) beta 1 is a key enzyme in nuclear lipid signal transduction affecting cell cycle progression and may be directly…”
Get full text

Nuclear phospholipase C beta1 (PLCbeta1) affects CD24 expression in murine erythroleukemia cells by Fiume, Roberta, Faenza, Irene, Matteucci, Alessandro, Astolfi, Annalisa, Vitale, Marco, Martelli, Alberto Maria, Cocco, Lucio

“…Inositide-specific phospholipase C (PLC) beta1 is a key enzyme in nuclear lipid signal transduction affecting cell cycle progression and may be directly…”
Get full text

Nuclear Phospholipase C β1 (PLCβ1) Affects CD24 Expression in Murine Erythroleukemia Cells by Roberta Fiume, Irene Faenza, Alessandro Matteucci, Annalisa Astolfi, Marco Vitale, Alberto Maria Martelli, Lucio Cocco

“…Inositide-specific phospholipase C (PLC) β1 is a key enzyme in nuclear lipid signal transduction affecting cell cycle progression and may be directly involved…”
Get full text

Nuclear diacylglycerol kinase-θ is activated in response to nerve growth factor stimulation of PC12 cells by Tabellini, Giovanna, Billi, Anna Maria, Falà, Federica, Cappellini, Alessandra, Evagelisti, Camilla, Manzoli, Lucia, Cocco, Lucio, Martelli, Alberto Maria

“…Previous evidence from independent laboratories has shown that the nucleus contains diacylglycerol kinase (DGK) isoforms, i.e., the enzymes, which yield…”
Get full text