Search Results - "Martelli, Alberto M."

Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging by Simioni, Carolina, Zauli, Giorgio, Martelli, Alberto M, Vitale, Marco, Sacchetti, Gianni, Gonelli, Arianna, Neri, Luca M

“…Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health,…”
Get full text

Current treatment strategies for inhibiting mTOR in cancer by Chiarini, Francesca, Evangelisti, Camilla, McCubrey, James A, Martelli, Alberto M

“…Highlights • We delineate the roles of mTOR in the biology of healthy and cancer cells. • We focus on the current therapeutic strategies used to inhibit mTOR…”
Get full text

Deregulated PTEN/PI3K/AKT/mTOR signaling in prostate cancer: Still a potential druggable target? by Braglia, Luca, Zavatti, Manuela, Vinceti, Marco, Martelli, Alberto M., Marmiroli, Sandra

“…Although the prognosis of patients with localized prostate cancer is good after surgery, with a favorable response to androgen deprivation therapy, about one…”
Get full text

The Role Played by Wnt/β-Catenin Signaling Pathway in Acute Lymphoblastic Leukemia by Chiarini, Francesca, Paganelli, Francesca, Martelli, Alberto M, Evangelisti, Camilla

“…Acute lymphoblastic leukemia (ALL) is an aggressive hematologic neoplastic disorder that arises from the clonal expansion of transformed T-cell or B-cell…”
Get full text

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer by Duda, Przemysław, Akula, Shaw M, Abrams, Stephen L, Steelman, Linda S, Martelli, Alberto M, Cocco, Lucio, Ratti, Stefano, Candido, Saverio, Libra, Massimo, Montalto, Giuseppe, Cervello, Melchiorre, Gizak, Agnieszka, Rakus, Dariusz, McCubrey, James A

“…Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although GSK-3 originally was identified to have functions in regulation of…”
Get full text

Roles and clinical implications of microRNAs in acute lymphoblastic leukemia by Ultimo, Simona, Martelli, Alberto M., Zauli, Giorgio, Vitale, Marco, Calin, George A., Neri, Luca M.

“…MicroRNAs (miRNAs) are a class of small noncoding RNAs which regulate the expression of target genes by binding to messenger RNAs. miRNAs play a role in…”
Get full text

Understanding the Roles of the Hedgehog Signaling Pathway during T-Cell Lymphopoiesis and in T-Cell Acute Lymphoblastic Leukemia (T-ALL) by Martelli, Alberto M, Paganelli, Francesca, Truocchio, Serena, Palumbo, Carla, Chiarini, Francesca, McCubrey, James A

“…The Hedgehog (HH) signaling network is one of the main regulators of invertebrate and vertebrate embryonic development. Along with other networks, such as…”
Get full text

Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate by Tanaka, Toshiaki, Hozumi, Yasukazu, Martelli, Alberto M., Iino, Mitsuyoshi, Goto, Kaoru

“…The p53 tumor suppressor regulates expression of genes involved in various stress responses. Upon genotoxic stress, p53 induces target genes regulating cell…”
Get full text

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance by McCubrey, James A., Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Wong, Ellis W.T., Chang, Fumin, Lehmann, Brian, Terrian, David M., Milella, Michele, Tafuri, Agostino, Stivala, Franca, Libra, Massimo, Basecke, Jorg, Evangelisti, Camilla, Martelli, Alberto M., Franklin, Richard A.

“…Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent…”
Get full text

Advances in understanding the mechanisms of evasive and innate resistance to mTOR inhibition in cancer cells by Chiarini, Francesca, Evangelisti, Camilla, Lattanzi, Giovanna, McCubrey, James A., Martelli, Alberto M.

“…The development of drug-resistance by neoplastic cells is recognized as a major cause of targeted therapy failure and disease progression. The mechanistic…”
Get full text

Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update by Evangelisti, Camilla, Chiarini, Francesca, McCubrey, James A, Martelli, Alberto M

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood malignancy that arises from the clonal expansion of transformed T-cell precursors. Although…”
Get full text

Impact of physical exercise in cancer survivors during and after antineoplastic treatments by Ferioli, Martina, Zauli, Giorgio, Martelli, Alberto M, Vitale, Marco, McCubrey, James A, Ultimo, Simona, Capitani, Silvano, Neri, Luca M

“…Cancer patients experience symptoms and adverse effects of treatments that may last even after the end of treatments. Exercise is a safe, non-pharmacological…”
Get full text

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention by Davis, Nicole M, Sokolosky, Melissa, Stadelman, Kristin, Abrams, Steve L, Libra, Massimo, Candido, Saverio, Nicoletti, Ferdinando, Polesel, Jerry, Maestro, Roberta, D'Assoro, Antonino, Drobot, Lyudmyla, Rakus, Dariusz, Gizak, Agnieszka, Laidler, Piotr, Dulińska-Litewka, Joanna, Basecke, Joerg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Montalto, Giuseppe, Cervello, Melchiorre, Fitzgerald, Timothy L, Demidenko, Zoya, Martelli, Alberto M, Cocco, Lucio, Steelman, Linda S, McCubrey, James A

“…The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The…”
Get full text

The Cutting Edge: The Role of mTOR Signaling in Laminopathies by Chiarini, Francesca, Evangelisti, Camilla, Cenni, Vittoria, Fazio, Antonietta, Paganelli, Francesca, Martelli, Alberto M, Lattanzi, Giovanna

“…The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase that regulates anabolic and catabolic processes, in response to…”
Get full text

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging by Steelman, Linda S, Chappell, William H, Abrams, Stephen L, Kempf, Ruth C, Long, Jacquelyn, Laidler, Piotr, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Stivala, Franca, Mazzarino, Maria C, Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Nicoletti, Ferdinando, Libra, Massimo, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Bäsecke, Jörg, Cocco, Lucio, Evangelisti, Camilla, Martelli, Alberto M, Montalto, Giuseppe, Cervello, Melchiorre, McCubrey, James A

“…Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these…”
Get full text

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation by Pyne, Nigel J., McNaughton, Melissa, Boomkamp, Stephanie, MacRitchie, Neil, Evangelisti, Cecilia, Martelli, Alberto M., Jiang, Hui-Rong, Ubhi, Satvir, Pyne, Susan

“…Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from…”
Get full text

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells by McCubrey, James A, Fitzgerald, Timothy L, Yang, Li V, Lertpiriyapong, Kvin, Steelman, Linda S, Abrams, Stephen L, Montalto, Giuseppe, Cervello, Melchiorre, Neri, Luca M, Cocco, Lucio, Martelli, Alberto M, Laidler, Piotr, Dulińska-Litewka, Joanna, Rakus, Dariusz, Gizak, Agnieszka, Nicoletti, Ferdinando, Falzone, Luca, Candido, Saverio, Libra, Massimo

“…Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin,…”
Get full text

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance by McCubrey, James A, Steelman, Linda S, Chappell, William H, Abrams, Stephen L, Franklin, Richard A, Montalto, Giuseppe, Cervello, Melchiorre, Libra, Massimo, Candido, Saverio, Malaponte, Grazia, Mazzarino, Maria C, Fagone, Paolo, Nicoletti, Ferdinando, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Milella, Michele, Tafuri, Agostino, Chiarini, Francesca, Evangelisti, Camilla, Cocco, Lucio, Martelli, Alberto M

“…The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine…”
Get full text

The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis by Martelli, Alberto M., Evangelisti, Camilla, Chiarini, Francesca, Grimaldi, Cecilia, Cappellini, Alessandra, Ognibene, Andrea, McCubrey, James A.

“…The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway mediates diverse and important physiological cell functions…”
Get full text

Influence of physical exercise on microRNAs in skeletal muscle regeneration, aging and diseases by Ultimo, Simona, Zauli, Giorgio, Martelli, Alberto M, Vitale, Marco, McCubrey, James A, Capitani, Silvano, Neri, Luca M

“…Skeletal muscle is a dynamic tissue with remarkable plasticity and its growth and regeneration are highly organized, with the activation of specific…”
Get full text