Search Results - "Marta, Freire"

Measuring biological aging in humans: A quest by Ferrucci, Luigi, Gonzalez‐Freire, Marta, Fabbri, Elisa, Simonsick, Eleanor, Tanaka, Toshiko, Moore, Zenobia, Salimi, Shabnam, Sierra, Felipe, Cabo, Rafael

“…The global population of individuals over the age of 65 is growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older…”
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Plasma proteomic signature of age in healthy humans by Tanaka, Toshiko, Biancotto, Angelique, Moaddel, Ruin, Moore, Ann Zenobia, Gonzalez‐Freire, Marta, Aon, Miguel A., Candia, Julián, Zhang, Pingbo, Cheung, Foo, Fantoni, Giovanna, Semba, Richard D., Ferrucci, Luigi, Stagliano, Katie E. R., Sellers, Brian, Kotliarov, Yuri

“…To characterize the proteomic signature of chronological age, 1,301 proteins were measured in plasma using the SOMAscan assay (SomaLogic, Boulder, CO, USA) in…”
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Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research by Fabbri, Elisa, MD, Zoli, Marco, MD, Gonzalez-Freire, Marta, PhD, Salive, Marcel E., MD, MPH, Studenski, Stephanie A., MD, MPH, Ferrucci, Luigi, MD, PhD

“…Abstract Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for…”
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Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging by Gonzalez‐Freire, Marta, Scalzo, Paul, D'Agostino, Jarod, Moore, Zenobia A., Diaz‐Ruiz, Alberto, Fabbri, Elisa, Zane, Ariel, Chen, Brian, Becker, Kevin G., Lehrmann, Elin, Zukley, Linda, Chia, Chee W., Tanaka, Toshiko, Coen, Paul M., Bernier, Michel, Cabo, Rafael, Ferrucci, Luigi

“…Summary Mitochondrial function in human skeletal muscle declines with age. Most evidence for this decline comes from studies that assessed mitochondrial…”
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The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature by Gonzalez‐Freire, Marta, Semba, Richard D., Ubaida‐Mohien, Ceereena, Fabbri, Elisa, Scalzo, Paul, Højlund, Kurt, Dufresne, Craig, Lyashkov, Alexey, Ferrucci, Luigi

“…Skeletal muscle is a large organ that accounts for up to half the total mass of the human body. A progressive decline in muscle mass and strength occurs with…”
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Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging by Semba, Richard D., Zhang, Pingbo, Adelnia, Fatemeh, Sun, Kai, Gonzalez‐Freire, Marta, Salem, Norman, Brennan, Nicholas, Spencer, Richard G., Fishbein, Kenneth, Khadeer, Mohammed, Shardell, Michelle, Moaddel, Ruin, Ferrucci, Luigi

“…The decrease in skeletal muscle mitochondrial oxidative capacity with age adversely affects muscle strength and physical performance. Factors that are…”
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Muscle cannabinoid 1 receptor regulates Il‐6 and myostatin expression, governing physical performance and whole‐body metabolism by González‐Mariscal, Isabel, Montoro, Rodrigo A., O'Connel, Jennifer F., Kim, Yoo, Gonzalez‐Freire, Marta, Liu, Qing‐Rong, Alfaras, Irene, Carlson, Olga D., Lehrmann, Elin, Zhang, Yongqing, Becker, Kevin G., Hardivillé, Stephan, Ghosh, Paritosh, Egan, Josephine M.

“…ABSTRACTSarcopenic obesity, the combination of skeletal muscle mass and function loss with an increase in body fat, is associated with physical limitations,…”
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Plasma-induced nanoparticle aggregation for stratifying COVID-19 patients according to disease severity by Santopolo, Giulia, Clemente, Antonio, González-Freire, Marta, Russell, Steven M., Vaquer, Andreu, Barón, Enrique, Aranda, María, Socias, Antonia, del Castillo, Alberto, Borges, Marcio, de la Rica, Roberto

“…Stratifying patients according to disease severity has been a major hurdle during the COVID-19 pandemic. This usually requires evaluating the levels of several…”
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COVID-19: In the Eye of the Cytokine Storm by de la Rica, Roberto, Borges, Marcio, Gonzalez-Freire, Marta

“…The dysregulated release of cytokines has been identified as one of the key factors behind poorer outcomes in COVID-19. This "cytokine storm" produces an…”
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Searching for a mitochondrial root to the decline in muscle function with ageing by Gonzalez‐Freire, Marta, Adelnia, Fatemeh, Moaddel, Ruin, Ferrucci, Luigi

“…Sarcopenia, the age‐related loss of muscle mass and strength, is linked to a range of adverse outcomes, such as impaired physical performance, cognitive…”
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Is there an optimum endurance polygenic profile? by Ruiz, Jonatan R., Gómez‐Gallego, Félix, Santiago, Catalina, González‐Freire, Marta, Verde, Zoraida, Foster, Carl, Lucia, Alejandro

“…We analysed seven genetic polymorphisms that are candidates to explain individual variations in human endurance phenotypic traits, at least in Caucasian people…”
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Early body composition, but not body mass, is associated with future accelerated decline in muscle quality by Fabbri, Elisa, Chiles Shaffer, Nancy, Gonzalez‐Freire, Marta, Shardell, Michelle D., Zoli, Marco, Studenski, Stephanie A., Ferrucci, Luigi

“…Background Muscle quality (MQ) or strength‐to‐mass ratio declines with aging, but the rate of MQ change with aging is highly heterogeneous across individuals…”
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A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes by Semba, Richard D., Zhang, Pingbo, Zhu, Min, Fabbri, Elisa, Gonzalez‐Freire, Marta, Moaddel, Ruin, Geng‐Spyropoulos, Minghui, Ferrucci, Luigi

“…Circulating polypeptides and proteins have been implicated in reversing or accelerating aging phenotypes, including growth/differentiation factor 8 (GDF8),…”
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A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH‐related proteins 1–5 in human plasma by Zhang, Pingbo, Zhu, Min, Geng‐Spyropoulos, Minghui, Shardell, Michelle, Gonzalez‐Freire, Marta, Gudnason, Vilmundur, Eiriksdottir, Gudny, Schaumberg, Debra, Eyk, Jennifer E., Ferrucci, Luigi, Semba, Richard D.

“…Age‐related macular degeneration (AMD) is a leading cause of visual loss among older adults. Two variants in the complement factor H (CFH) gene, Y402H and…”
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Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease by Kosmac, Kate, Gonzalez-Freire, Marta, McDermott, Mary M, White, Sarah H, Walton, R Grace, Sufit, Robert L, Tian, Lu, Li, Lingyu, Kibbe, Melina R, Criqui, Michael H, Guralnik, Jack M, S Polonsky, Tamar, Leeuwenburgh, Christiaan, Ferrucci, Luigi, Peterson, Charlotte A

“…Background Peripheral artery disease (PAD) is a manifestation of atherosclerosis characterized by reduced blood flow to the lower extremities and mobility…”
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Reconsidering the Role of Mitochondria in Aging by Gonzalez-Freire, Marta, de Cabo, Rafael, Bernier, Michel, Sollott, Steven J, Fabbri, Elisa, Navas, Placido, Ferrucci, Luigi

“…Mitochondrial dysfunction has long been considered a major contributor to aging and age-related diseases. Harman's Mitochondrial Free Radical Theory of Aging…”
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Associations of Peripheral Artery Disease With Calf Skeletal Muscle Mitochondrial DNA Heteroplasmy by Gonzalez-Freire, Marta, Moore, A Zenobia, Peterson, Charlotte A, Kosmac, Kate, McDermott, Mary M, Sufit, Robert L, Guralnik, Jack M, Polonsky, Tamar, Tian, Lu, Kibbe, Melina R, Criqui, Michael H, Li, Lingyu, Leeuwenburgh, Christian, Ferrucci, Luigi

“…Background Patients with peripheral artery disease (PAD) undergo frequent episodes of ischemia-reperfusion in lower extremity muscles that may negatively…”
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Environmental Enteric Dysfunction Is Associated With Altered Bile Acid Metabolism by Semba, Richard D., Gonzalez‐Freire, Marta, Moaddel, Ruin, Trehan, Indi, Maleta, Kenneth M., Khadeer, Mohammed, Ordiz, Maria Isabel, Ferrucci, Luigi, Manary, Mark J.

“…ABSTRACT Objectives: Environmental enteric dysfunction (EED), a clinically asymptomatic condition characterized by inflammation of the small bowel mucosa,…”
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The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle by Gonzalez-Freire, Marta, de Cabo, Rafael, Studenski, Stephanie A, Ferrucci, Luigi

“…Aging is associated with a progressive loss of muscle mass and strength and a decline in neurophysiological functions. Age-related neuromuscular junction (NMJ)…”
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Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria by Ubaida-Mohien, Ceereena, Lyashkov, Alexey, Gonzalez-Freire, Marta, Tharakan, Ravi, Shardell, Michelle, Moaddel, Ruin, Semba, Richard D, Chia, Chee W, Gorospe, Myriam, Sen, Ranjan, Ferrucci, Luigi

“…A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline…”
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