Search Results - "Martínez Nieto, Guillermo"

HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse Testis but Not in Adults by Junnila, Arttu, Zhang, Fu-Ping, Martínez Nieto, Guillermo, Hakkarainen, Janne, Mäkelä, Juho-Antti, Ohlsson, Claes, Sipilä, Petra, Poutanen, Matti

“…Abstract Hydroxysteroid (17β) dehydrogenase (HSD17B) enzymes convert 17-ketosteroids to 17beta-hydroxysteroids, an essential step in testosterone biosynthesis…”
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Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model by Martínez-Nieto, Guillermo, Heljasvaara, Ritva, Heikkinen, Anne, Kaski, Hanne-Kaisa, Devarajan, Raman, Rinne, Otto, Henriksson, Charlotta, Thomson, Emmi, von Hertzen, Camilla, Miinalainen, Ilkka, Ruotsalainen, Heli, Pihlajaniemi, Taina, Karppinen, Sanna-Maria

“…Basement membrane (BM) zone-associated collagen XV (ColXV) has been shown to suppress the malignancy of tumour cells, and its restin domain can inhibit…”
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Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models by Devarajan, Raman, Izzi, Valerio, Peltoketo, Hellevi, Rask, Gunilla, Kauppila, Saila, Väisänen, Marja-Riitta, Ruotsalainen, Heli, Martínez-Nieto, Guillermo, Karppinen, Sanna-Maria, Väisänen, Timo, Kaur, Inderjeet, Koivunen, Jussi, Sasaki, Takako, Winqvist, Robert, Manninen, Aki, Wärnberg, Fredrik, Sund, Malin, Pihlajaniemi, Taina, Heljasvaara, Ritva

“…The tumor extracellular matrix (ECM) critically regulates cancer progression and treatment response. Expression of the basement membrane component collagen…”
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Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis by Martínez-Nieto, Guillermo A., Teppo, Hanna-Riikka, Petrelius, Noora, Izzi, Valerio, Devarajan, Raman, Petäistö, Tiina, Liu, Hengshuo, Kim, Kris S., Karppinen, Sanna-Maria, Ruotsalainen, Heli, Koivunen, Jarkko, Mäki, Joni M., Walker, Gilbert C., Pihlajaniemi, Taina, Gullberg, Donald, Heljasvaara, Ritva

“…Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing…”
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Modeling Rare Human Disorders in Mice: The Finnish Disease Heritage by Zárybnický, Tomáš, Heikkinen, Anne, Kangas, Salla M, Karikoski, Marika, Martínez-Nieto, Guillermo Antonio, Salo, Miia H, Uusimaa, Johanna, Vuolteenaho, Reetta, Hinttala, Reetta, Sipilä, Petra, Kuure, Satu

“…The modification of genes in animal models has evidently and comprehensively improved our knowledge on proteins and signaling pathways in human physiology and…”
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Inhibition of RNA Binding in SND1 Increases the Levels of miR-1-3p and Sensitizes Cancer Cells to Navitoclax by Lehmusvaara, Saara, Haikarainen, Teemu, Saarikettu, Juha, Martinez Nieto, Guillermo, Silvennoinen, Olli

“…SND1 is an RNA-binding protein overexpressed in large variety of cancers. SND1 has been proposed to enhance stress tolerance in cancer cells, but the molecular…”
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Angiogenin Secretion From Hepatoma Cells Activates Hepatic Stellate Cells To Amplify A Self-Sustained Cycle Promoting Liver Cancer by Bárcena, Cristina, Stefanovic, Milica, Tutusaus, Anna, Martinez-Nieto, Guillermo A., Martinez, Laura, García-Ruiz, Carmen, de Mingo, Alvaro, Caballeria, Juan, Fernandez-Checa, José C., Marí, Montserrat, Morales, Albert

“…Hepatocellular carcinoma (HCC) frequently develops in a pro-inflammatory and pro-fibrogenic environment with hepatic stellate cells (HSCs) remodeling the…”
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Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma by Stefanovic, Milica, Tutusaus, Anna, Martinez-Nieto, Guillermo A, Bárcena, Cristina, de Gregorio, Estefania, Moutinho, Catia, Barbero-Camps, Elisabet, Villanueva, Alberto, Colell, Anna, Marí, Montserrat, García-Ruiz, Carmen, Fernandez-Checa, Jose C, Morales, Albert

“…Evasive mechanisms triggered by the tyrosine kinase inhibitor sorafenib reduce its efficacy in hepatocellular carcinoma (HCC) treatment. Drug-resistant cancer…”
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