Search Results - "Martínez Gómez, María Amparo"
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Relationship Between Glucocerebrosidase Activity and Clinical Response to Enzyme Replacement Therapy in Patients With Gaucher Disease Type I
Published in Basic & clinical pharmacology & toxicology (01-07-2018)“…The quantification of enzyme activity in the patient treated with enzyme replacement therapy (ERT) has been suggested as a tool for dosage individualization,…”
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Topical rapamycin in the treatment of facial angiofibromas in tuberous sclerosis: a systematic review based on evidence
Published in The Journal of dermatological treatment (19-05-2022)“…facial angiofibromas of tuberous sclerosis are the most prevalent cutaneous manifestation, affecting 80% of patients, which cause facial lesions with negative…”
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Cellular Uptake of Glucocerebrosidase in Gaucher Patients Receiving Enzyme Replacement Treatment
Published in Clinical pharmacokinetics (01-09-2016)“…Background Enzyme replacement therapy (ERT) is currently the standard treatment for patients with Gaucher disease type I (GD1), but the pharmacokinetics have…”
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Physicochemical stability of binary admixtures of paracetamol and dexketoprofen-trometamol for patient-controlled analgesia use
Published in European journal of hospital pharmacy. Science and practice (01-11-2019)“…BackgroundIntravenous admixtures of dexketoprofen-trometamol and paracetamol are frequently used in clinical practice due to synergism obtained administering…”
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Stability studies of binary mixtures of haloperidol and/or midazolam with other drugs for parenteral administration
Published in Journal of palliative medicine (01-12-2007)“…Haloperidol and or midazolam are frequently combined with other drugs in the same solution and infused parenterally over several days to treat symptoms. The…”
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Quantitative assessment of the exposure–efficacy relationship of glucocerebrosidase using Markovian elements in Gaucher patients treated with enzyme replacement therapy
Published in British journal of clinical pharmacology (01-06-2022)“…Aims The aims of this study are (i) to develop a population pharmacokinetic model of enzyme activity in Gaucher‐type 1 (GD1) patients after intravenous…”
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Effectiveness and safety of liposomal rapamycin for the treatment of facial angiofibromas in tuberous sclerosis
Published in Farmacia hospitalaria (07-06-2024)“…Topical rapamycin is the pharmacological treatment of choice for facial angiofibromas in rare tuberous sclerosis disease. A new, more advanced, and complex…”
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Chemical stability and physical compatibility of meropenem in admixtures for continuous and extended intravenous infusions
Published in Enfermedades infecciosas y microbiologia clinica (English ed.) (01-12-2023)“…INTRODUCTIONProlonged intravenous infusion of beta-lactams increase the clinical cure rate compared to conventional administration in critical or septic…”
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P1082COMPARISON OF THE REMOVAL OF PROTEIN-BOUND TOXINS AND LARGE MIDDLE MOLECULES WITH HIGH-FLUX PMMA AND MEDIUM CUT-OFF DIALYZERS
Published in Nephrology, dialysis, transplantation (01-06-2020)“…Abstract Background and Aims Dialytic clearance of protein-bound toxins and large middle molecules is poor by diffusive treatment and limited by high-flux…”
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Enantioseparation of phenotiazines by affinity electrokinetic chromatography using human serum albumin as chiral selector
Published in Analytica chimica acta (2007)“…Nowadays, there is a special interest within the pharmaceutical laboratories to develop single enantiomer formulations and consequently a need for analytical…”
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A Wide Linearity Range Method for the Determination of Lenalidomide in Plasma by High-Performance Liquid Chromatography: Application to Pharmacokinetic Studies
Published in Journal of Laboratory Automation (01-12-2016)“…A wide linearity range analytical method for the determination of lenalidomide in patients with multiple myeloma for pharmacokinetic studies is required…”
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Evaluation of enantioselective binding of propanocaine to human serum albumin by ultrafiltration and electrokinetic chromatography under intermediate precision conditions
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15-03-2012)“…► First evidence on enantioselective binding of propanocaine to human serum albumin. ► Approximate in vivo conditions allows in vitro data unapproachable from…”
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Evaluation of enantioselective binding of basic drugs to plasma by ACE
Published in Electrophoresis (01-09-2007)“…The present paper deals with the evaluation of the stereoselective binding of antihistamines (brompheniramine, chlorpheniramine, hydroxyzine, orphenadrine and…”
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Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE
Published in Electrophoresis (01-08-2007)“…The drug binding to plasma and tissue proteins is a fundamental factor in determining the overall pharmacological activity of a drug. HSA, together with…”
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Optimization, Formulation, and Stability of Topical Rapamycin Used for Rare Tuberous Sclerosis Disease: from Ointment to Liposomes
Published in Journal of pharmaceutical innovation (01-12-2023)“…Introduction Topical rapamycin has been established as an effective and safe therapy for facial angiofibromas in tuberous sclerosis. Different formulations…”
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Chemical stability and physical compatibility of meropenem in admixtures for continuous and extended intravenous infusions
Published in Enfermedades infecciosas y microbiologia clinica (English ed.) (01-12-2023)“…Prolonged intravenous infusion of beta-lactams increase the clinical cure rate compared to conventional administration in critical or septic patients. This…”
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Microseparation techniques for the study of the enantioselectivity of drug-plasma protein binding
Published in Biomedical chromatography (01-03-2009)“…Stereoselectivity in protein binding can have a significant effect on the pharmacokinetic and pharmacodynamic properties of chiral drugs. The investigation of…”
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Enantioseparation of nuarimol by affinity electrokinetic chromatography-partial filling technique using human serum albumin as chiral selector
Published in Journal of separation science (01-10-2008)“…The present paper deals with the enantiomeric separation of nuarimol enantiomers by affinity EKC‐partial filling technique using HSA as chiral selector…”
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