Search Results - "Martínez Cuesta, Sergio"

Chemical profiling of DNA G-quadruplex-interacting proteins in live cells by Zhang, Xiaoyun, Spiegel, Jochen, Martínez Cuesta, Sergio, Adhikari, Santosh, Balasubramanian, Shankar

“…DNA–protein interactions regulate critical biological processes. Identifying proteins that bind to specific, functional genomic loci is essential to understand…”
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The Classification and Evolution of Enzyme Function by Martínez Cuesta, Sergio, Rahman, Syed Asad, Furnham, Nicholas, Thornton, Janet M.

“…Enzymes are the proteins responsible for the catalysis of life. Enzymes sharing a common ancestor as defined by sequence and structure similarity are grouped…”
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Sequencing abasic sites in DNA at single-nucleotide resolution by Liu, Zheng J., Martínez Cuesta, Sergio, van Delft, Pieter, Balasubramanian, Shankar

“…In DNA, the loss of a nucleobase by hydrolysis generates an abasic site. Formed as a result of DNA damage, as well as a key intermediate during the base…”
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5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells by Raiber, Eun-Ang, Portella, Guillem, Martínez Cuesta, Sergio, Hardisty, Robyn, Murat, Pierre, Li, Zhe, Iurlaro, Mario, Dean, Wendy, Spindel, Julia, Beraldi, Dario, Liu, Zheng, Dawson, Mark A., Reik, Wolf, Balasubramanian, Shankar

“…Nucleosomes are the basic unit of chromatin that help the packaging of genetic material while controlling access to the genetic information. The underlying DNA…”
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Reaction Decoder Tool (RDT): extracting features from chemical reactions by Rahman, Syed Asad, Torrance, Gilliean, Baldacci, Lorenzo, Martínez Cuesta, Sergio, Fenninger, Franz, Gopal, Nimish, Choudhary, Saket, May, John W, Holliday, Gemma L, Steinbeck, Christoph, Thornton, Janet M

“…Extracting chemical features like Atom-Atom Mapping (AAM), Bond Changes (BCs) and Reaction Centres from biochemical reactions helps us understand the chemical…”
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Genetic interactions of G-quadruplexes in humans by Zyner, Katherine G, Mulhearn, Darcie S, Adhikari, Santosh, Martínez Cuesta, Sergio, Di Antonio, Marco, Erard, Nicolas, Hannon, Gregory J, Tannahill, David, Balasubramanian, Shankar

“…G-quadruplexes (G4) are alternative nucleic acid structures involved in transcription, translation and replication. Aberrant G4 formation and stabilisation is…”
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Sequencing 5‐Hydroxymethyluracil at Single‐Base Resolution by Kawasaki, Fumiko, Martínez Cuesta, Sergio, Beraldi, Dario, Mahtey, Areeb, Hardisty, Robyn E., Carrington, Mark, Balasubramanian, Shankar

“…5‐hydroxymethyluracil (5hmU) is formed through oxidation of thymine both enzymatically and non‐enzymatically in various biological systems. Although 5hmU has…”
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Genome-wide DNA Methylation Signatures Are Determined by DNMT3A/B Sequence Preferences by Mao, Shi-Qing, Cuesta, Sergio Martínez, Tannahill, David, Balasubramanian, Shankar

“…Cytosine methylation is an important epigenetic mark, but how the distinctive patterns of DNA methylation arise remains elusive. For the first time, we…”
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Exploring the chemistry and evolution of the isomerases by Cuesta, Sergio Martínez, Rahman, Syed Asad, Thornton, Janet M.

“…Isomerization reactions are fundamental in biology, and isomers usually differ in their biological role and pharmacological effects. In this study, we have…”
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DNA G-quadruplex structures mold the DNA methylome by Mao, Shi-Qing, Ghanbarian, Avazeh T., Spiegel, Jochen, Martínez Cuesta, Sergio, Beraldi, Dario, Di Antonio, Marco, Marsico, Giovanni, Hänsel-Hertsch, Robert, Tannahill, David, Balasubramanian, Shankar

“…Control of DNA methylation level is critical for gene regulation, and the factors that govern hypomethylation at CpG islands (CGIs) are still being uncovered…”
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Characterising Complex Enzyme Reaction Data by Dönertaş, Handan Melike, Martínez Cuesta, Sergio, Rahman, Syed Asad, Thornton, Janet M

“…The relationship between enzyme-catalysed reactions and the Enzyme Commission (EC) number, the widely accepted classification scheme used to characterise…”
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G-quadruplexes are transcription factor binding hubs in human chromatin by Spiegel, Jochen, Cuesta, Sergio Martínez, Adhikari, Santosh, Hänsel-Hertsch, Robert, Tannahill, David, Balasubramanian, Shankar

“…The binding of transcription factors (TF) to genomic targets is critical in the regulation of gene expression. Short, double-stranded DNA sequence motifs are…”
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Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma by Raiber, Eun-Ang, Beraldi, Dario, Martínez Cuesta, Sergio, McInroy, Gordon R., Kingsbury, Zoya, Becq, Jennifer, James, Terena, Lopes, Margarida, Allinson, Kieren, Field, Sarah, Humphray, Sean, Santarius, Thomas, Watts, Colin, Bentley, David, Balasubramanian, Shankar

“…Aberrant genetic and epigenetic variations drive malignant transformation and are hallmarks of cancer. Using PCR-free sample preparation we achieved the first…”
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Design and Characterization of 1D Nanotubes and 2D Periodic Arrays Self-Assembled from DNA Multi-Helix Bundles by Wang, Tong, Schiffels, Daniel, Martinez Cuesta, Sergio, Kuchnir Fygenson, Deborah, Seeman, Nadrian C

“…Among the key goals of structural DNA nanotechnology are to build highly ordered structures self-assembled from individual DNA motifs in 1D, 2D, and finally…”
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Binging from Food to Alcohol: A Sequential Interaction Between Binging Behaviors in Male Wistar Rats by Cuesta-Martínez, Sergio, Ruiz-Leyva, Leandro, Jiménez-García, Ana María, Aparicio-Mescua, Teresa, López-Guarnido, Olga, Pautassi, Ricardo Marcos, Morón, Ignacio, Cendán, Cruz Miguel

“…The development of excessive alcohol (ethanol) and/or highly palatable food self-administration is an essential task to elucidate the neurobiological…”
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Genome surveillance by HUSH-mediated silencing of intronless mobile elements by Seczynska, Marta, Bloor, Stuart, Cuesta, Sergio Martinez, Lehner, Paul J.

“…All life forms defend their genome against DNA invasion. Eukaryotic cells recognize incoming DNA and limit its transcription through repressive chromatin…”
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Sequencing 5‐Hydroxymethyluracil at Single‐Base Resolution by Kawasaki, Fumiko, Martínez Cuesta, Sergio, Beraldi, Dario, Mahtey, Areeb, Hardisty, Robyn E., Carrington, Mark, Balasubramanian, Shankar

“…5‐hydroxymethyluracil (5hmU) is formed through oxidation of thymine both enzymatically and non‐enzymatically in various biological systems. Although 5hmU has…”
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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr by Dupont, Liane, Bloor, Stuart, Williamson, James C., Cuesta, Sergio Martínez, Shah, Raven, Teixeira-Silva, Ana, Naamati, Adi, Greenwood, Edward J.D., Sarafianos, Stefan G., Matheson, Nicholas J., Lehner, Paul J.

“…Silencing of nuclear DNA is an essential feature of innate immune responses to invading pathogens. Early in infection, unintegrated lentiviral cDNA accumulates…”
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RNA G-quadruplex structures control ribosomal protein production by Varshney, Dhaval, Cuesta, Sergio Martinez, Herdy, Barbara, Abdullah, Ummi Binti, Tannahill, David, Balasubramanian, Shankar

“…Four-stranded G-quadruplex (G4) structures form from guanine-rich tracts, but the extent of their formation in cellular RNA and details of their role in RNA…”
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EC-BLAST: a tool to automatically search and compare enzyme reactions by Rahman, Syed Asad, Cuesta, Sergio Martinez, Furnham, Nicholas, Holliday, Gemma L, Thornton, Janet M

“…EC-BLAST is a Web-based tool allowing quantitative similarity searches between enzymes at the levels of bond-change, reaction-center or reaction-structure…”
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