Prophylactic thyroidectomy in children at risk for medullary thyroid carcinoma

The medullary thyroid carcinoma (MTC) is a rare neoplasia occurring during childhood. At present time the molecular examination of the proto-oncogen RET, related to syndromes of multiple endocrine neoplasia (MEN II) and familial medullary thyroid carcinoma (FMTC) to allows identify patients with ris...

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Bibliographic Details
Published in:	Cirugía pediátrica Vol. 18; no. 3; pp. 106 - 108
Main Authors:	Torres de Aguirre, A, Martínez Carol, A, Cabello Laureano, R, García Valles, C, Gómez Gila, A, del Valle Núñez, J
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-07-2005
Subjects:	Carcinoma, Medullary - genetics Carcinoma, Medullary - prevention & control Child Child, Preschool Female Humans Multiple Endocrine Neoplasia Type 2a - genetics Proto-Oncogene Proteins c-ret - genetics Thyroid Neoplasms - genetics Thyroid Neoplasms - prevention & control Thyroidectomy - methods
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Summary:	The medullary thyroid carcinoma (MTC) is a rare neoplasia occurring during childhood. At present time the molecular examination of the proto-oncogen RET, related to syndromes of multiple endocrine neoplasia (MEN II) and familial medullary thyroid carcinoma (FMTC) to allows identify patients with risk of suffering of medullary thyroid carcinoma in early ages, before the disease becomes clinically pronunced. Children with familial antecedents of MEN II or FMTC were biochemically (pentagastrin-stimulated) and genetically studied with the purpose of determining the risk of developing a MTC and in order to assess the possibilities of making a prophylactic thyroidectomy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Report-3 ObjectType-Case Study-4
ISSN:	0214-1221