Search Results - "Martínez‐Moreno, Julio M."

Magnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells by Díaz-Tocados, Juan M., Herencia, Carmen, Martínez-Moreno, Julio M., Montes de Oca, Addy, Rodríguez-Ortiz, Maria E., Vergara, Noemi, Blanco, Alfonso, Steppan, Sonja, Almadén, Yolanda, Rodríguez, Mariano, Muñoz-Castañeda, Juan R.

“…Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest that they may play an important role for the health in the field of…”
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Differential regulation of renal Klotho and FGFR1 in normal and uremic rats by Muñoz‐Castañeda, Juan R., Herencia, Carmen, Pendón‐Ruiz de Mier, Maria Victoria, Rodriguez‐Ortiz, Maria Encarnación, Diaz‐Tocados, Juan M., Vergara, Noemi, Martínez‐Moreno, Julio M., Salmerón, Maria Dolores, Richards, William G., Felsenfeld, Arnold, Kuro‐O, Makoto, Almadén, Yolanda, Rodríguez, Mariano

“…ABSTRACT In renal failure, hyperphosphatemia occurs despite a marked elevation in serum fibroblast growth factor (FGF)‐23. Abnormal regulation of the…”
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High phosphate induces a pro-inflammatory response by vascular smooth muscle cells and modulation by vitamin D derivatives by Martínez-Moreno, Julio M, Herencia, Carmen, de Oca, Addy Montes, Díaz-Tocados, Juan M, Vergara, Noemi, Gómez-Luna, M José, López-Argüello, Silvia D, Camargo, Antonio, Peralbo-Santaella, Esther, Rodríguez-Ortiz, Maria E, Canalejo, Antonio, Rodríguez, Mariano, Muñoz-Castañeda, Juan R, Almadén, Yolanda

“…In chronic kidney disease patients, high phosphate (HP) levels are associated with cardiovascular disease, the major cause of morbidity and mortality. Since…”
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Mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats by Acevedo, Luz M, Raya, Ana I, Martínez-Moreno, Julio M, Aguilera-Tejero, Escolástico, Rivero, José-Luis L

“…Obesity-related skeletal muscle changes include muscle atrophy, slow-to-fast fiber-type transformation, and impaired mitochondrial oxidative capacity. These…”
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TGF-β prevents phosphate-induced osteogenesis through inhibition of BMP and Wnt/β-catenin pathways by Guerrero, Fátima, Herencia, Carmen, Almadén, Yolanda, Martínez-Moreno, Julio M, Montes de Oca, Addy, Rodriguez-Ortiz, María Encarnación, Diaz-Tocados, Juan M, Canalejo, Antonio, Florio, Mónica, López, Ignacio, Richards, William G, Rodriguez, Mariano, Aguilera-Tejero, Escolástico, Muñoz-Castañeda, Juan R

“…Transforming growth factor-β (TGF-β) is a key cytokine during differentiation of mesenchymal stem cells (MSC) into vascular smooth muscle cells (VSMC). High…”
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Nuclear translocation of β-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype by Herencia, Carmen, Martínez-Moreno, Julio M, Herrera, Concepción, Corrales, Fernando, Santiago-Mora, Raquel, Espejo, Isabel, Barco, Monserrat, Almadén, Yolanda, de la Mata, Manuel, Rodríguez-Ariza, Antonio, Muñoz-Castañeda, Juan R

“…Wnt/β-catenin pathway controls biochemical processes related to cell differentiation. In committed cells the alteration of this pathway has been associated…”
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Procaine Inhibits Osteo/Odontogenesis through Wnt/β-Catenin Inactivation by Herencia, Carmen, Diaz-Tocados, Juan Miguel, Jurado, Lidia, Montes de Oca, Addy, Rodríguez-Ortiz, Maria Encarnación, Martín-Alonso, Carmen, Martínez-Moreno, Julio M, Vergara, Noemi, Rodríguez, Mariano, Almadén, Yolanda, Muñoz-Castañeda, Juan R

“…Periodontitis is a complex pathology characterized by the loss of alveolar bone. The causes and the mechanisms that promote this bone resorption still remain…”
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Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats by Diaz-Tocados, Juan M, Peralta-Ramirez, Alan, Rodríguez-Ortiz, María E, Raya, Ana I, Lopez, Ignacio, Pineda, Carmen, Herencia, Carmen, Montes de Oca, Addy, Vergara, Noemi, Steppan, Sonja, Pendon-Ruiz de Mier, M Victoria, Buendía, Paula, Carmona, Andrés, Carracedo, Julia, Alcalá-Díaz, Juan F, Frazao, Joao, Martínez-Moreno, Julio M, Canalejo, Antonio, Felsenfeld, Arnold, Rodriguez, Mariano, Aguilera-Tejero, Escolástico, Almadén, Yolanda, Muñoz-Castañeda, Juan R

“…Although magnesium has been shown to prevent vascular calcification in vitro, controlled in vivo studies in uremic animal models are limited. To determine…”
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Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration by Díaz-Tocados, Juan M, Rodríguez-Ortiz, María E, Almadén, Yolanda, Pineda, Carmen, Martínez-Moreno, Julio M, Herencia, Carmen, Vergara, Noemi, Pendón-Ruiz de Mier, M Victoria, Santamaría, Rafael, Rodelo-Haad, Cristian, Casado-Díaz, Antonio, Lorenzo, Víctor, Carvalho, Catarina, Frazão, João M, Felsenfeld, Arnold J, Richards, William G, Aguilera-Tejero, Escolástico, Rodríguez, Mariano, López, Ignacio, Muñoz-Castañeda, Juan R

“…Calcimimetics decrease parathyroid hormone (PTH) secretion in patients with secondary hyperparathyroidism. The decrease in PTH should cause a reduction in bone…”
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The direct effect of fibroblast growth factor 23 on vascular smooth muscle cell phenotype and function by Vergara, Noemi, de Mier, M Victoria Pendón-Ruiz, Rodelo-Haad, Cristian, Revilla-González, Gonzalo, Membrives, Cristina, Díaz-Tocados, Juan M, Martínez-Moreno, Julio M, Torralbo, Ana I, Herencia, Carmen, Rodríguez-Ortiz, María Encarnación, López-Baltanás, Rodrigo, Richards, Williams G, Felsenfeld, Arnold, Almadén, Yolanda, Martin-Malo, Alejandro, Ureña, Juan, Santamaría, Rafael, Soriano, Sagrario, Rodríguez, Mariano, Muñoz-Castañeda, Juan R

“…In chronic kidney disease (CKD) patients, increased levels of fibroblast growth factor 23 (FGF23) are associated with cardiovascular mortality. The…”
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Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration by Rodríguez-Ortiz, Maria E, Canalejo, Antonio, Herencia, Carmen, Martínez-Moreno, Julio M, Peralta-Ramírez, Alan, Perez-Martinez, Pablo, Navarro-González, Juan F, Rodríguez, Mariano, Peter, Mirjam, Gundlach, Kristina, Steppan, Sonja, Passlick-Deetjen, Jutta, Muñoz-Castañeda, Juan R, Almaden, Yolanda

“…The interest on magnesium (Mg) has grown since clinical studies have shown the efficacy of Mg-containing phosphate binders. However, some concern has arisen…”
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In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation by Martínez-Moreno, Julio M, Muñoz-Castañeda, Juan R, Herencia, Carmen, Oca, Addy Montes de, Estepa, Jose C, Canalejo, Rocio, Rodríguez-Ortiz, Maria E, Perez-Martinez, Pablo, Aguilera-Tejero, Escolástico, Canalejo, Antonio, Rodríguez, Mariano, Almadén, Yolanda

“…The present study investigates the differential effect of two vitamin D receptor agonists, calcitriol and paricalcitol, on human aortic smooth muscle cells…”
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PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI by Fontecha‐Barriuso, Miguel, Martín‐Sánchez, Diego, Martinez‐Moreno, Julio M, Carrasco, Susana, Ruiz‐Andrés, Olga, Monsalve, Maria, Sanchez‐Ramos, Cristina, Gómez, Manuel J, Ruiz‐Ortega, Marta, Sánchez‐Niño, Maria D, Cannata‐Ortiz, Pablo, Cabello, Ramiro, Gonzalez‐Enguita, Carmen, Ortiz, Alberto, Sanz, Ana B

“…PGC‐1α (peroxisome proliferator‐activated receptor gamma coactivator‐1α, PPARGC1A) regulates the expression of genes involved in energy homeostasis and…”
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Runt-related transcription factor 1 (RUNX1) is a mediator of acute kidney injury by Fontecha-Barriuso, Miguel, Villar-Gomez, Natalia, Guerrero-Mauvecin, Juan, Martinez-Moreno, Julio M, Carrasco, Susana, Martin-Sanchez, Diego, Rodríguez-Laguna, María, Gómez, Manuel J, Sanchez-Niño, María D, Ruiz-Ortega, Marta, Ortiz, Alberto, Sanz, Ana B

“…Treatment for acute kidney injury (AKI) is suboptimal. A better understanding of the pathogenesis of AKI may lead to new therapeutic approaches. Kidney…”
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Vitamin D modulates tissue factor and protease‐activated receptor 2 expression in vascular smooth muscle cells by Martinez‐Moreno, Julio M., Herencia, Carmen, Oca, Addy Montes de, Muñoz‐Castañeda, Juan R., Rodríguez‐Ortiz, M. Encarnación, Díaz‐Tocados, Juan M., Peralbo‐Santaella, Esther, Camargo, Antonio, Canalejo, Antonio, Rodriguez, Mariano, Velasco‐Gimena, Francisco, Almaden, Yolanda

“…Clinical and epidemiologic studies reveal an association between vitamin D deficiency and increased risk of cardiovascular disease. Because vascular smooth…”
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Human mesenchymal stromal cell lysates as a novel strategy to recover liver function by Herencia, Carmen, Almadén, Yolanda, Martínez-Moreno, Julio M, Espejo, Isabel, Herrera, Concha, Pérez-Sánchez, Carlos, Guerrero, Fátima, Ciria, Rubén, Briceño, Francisco Javier, Ferrín, Gustavo, de la Mata, Manuel, Muñoz-Castañeda, Juan R

“…It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation…”
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Epigenetic Modifiers as Potential Therapeutic Targets in Diabetic Kidney Disease by Martinez-Moreno, Julio M, Fontecha-Barriuso, Miguel, Martin-Sanchez, Diego, Guerrero-Mauvecin, Juan, Goma-Garces, Elena, Fernandez-Fernandez, Beatriz, Carriazo, Sol, Sanchez-Niño, Maria D, Ramos, Adrian M, Ruiz-Ortega, Marta, Ortiz, Alberto, Sanz, Ana B

“…Diabetic kidney disease is one of the fastest growing causes of death worldwide. Epigenetic regulators control gene expression and are potential therapeutic…”
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Magnesium inhibits Wnt/β-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells by Montes de Oca, Addy, Guerrero, Fatima, Martinez-Moreno, Julio M, Madueño, Juan A, Herencia, Carmen, Peralta, Alan, Almaden, Yolanda, Lopez, Ignacio, Aguilera-Tejero, Escolastico, Gundlach, Kristina, Büchel, Janine, Peter, Mirjam E, Passlick-Deetjen, Jutta, Rodriguez, Mariano, Muñoz-Castañeda, Juan R

“…Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the mechanism has not been revealed so far. This work used only slightly…”
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Molecular pathways driving omeprazole nephrotoxicity by Fontecha-Barriuso, Miguel, Martín-Sanchez, Diego, Martinez-Moreno, Julio M., Cardenas-Villacres, Daniela, Carrasco, Susana, Sanchez-Niño, Maria D., Ruiz-Ortega, Marta, Ortiz, Alberto, Sanz, Ana B.

“…Omeprazole, a proton pump inhibitor used to treat peptic ulcer and gastroesophageal reflux disease, has been associated to chronic kidney disease and acute…”
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The Contribution of Histone Crotonylation to Tissue Health and Disease: Focus on Kidney Health by Martinez-Moreno, Julio M, Fontecha-Barriuso, Miguel, Martín-Sánchez, Diego, Sánchez-Niño, Maria D, Ruiz-Ortega, Marta, Sanz, Ana B, Ortiz, Alberto

“…Acute kidney injury (AKI) and chronic kidney disease (CKD) are the most severe consequences of kidney injury. They are interconnected syndromes as CKD…”
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