Search Results - "Martínez‐Martínez, Arisai"
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Chronic administration of Cl‐amidine, a pan‐peptidylarginine deiminase inhibitor, does not reverse bone loss in two different murine models of osteoporosis
Published in Drug development research (01-02-2020)“…Recent in vitro studies have shown a role for the peptidyl‐arginine deiminases (PADs) in bone resorption. However, it is unknown whether these enzymes are…”
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High‐fat diet exacerbates pain‐like behaviors and periarticular bone loss in mice with CFA‐induced knee arthritis
Published in Obesity (Silver Spring, Md.) (01-05-2016)“…Objective Our aim was to quantify nociceptive spontaneous behaviors, knee edema, proinflammatory cytokines, bone density, and microarchitecture in high‐fat…”
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Characterization of pain-related behaviors, changes in bone microarchitecture and sensory innervation induced by chronic cadmium exposure in adult mice
Published in Neurotoxicology (Park Forest South) (01-03-2022)“…•Cadmium exposure in mice induced musculoskeletal-related pain-like behaviors.•Cadmium exposure produced trabecular bone loss at the femoral neck and…”
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Characterization of Mechanical Allodynia and Skin Innervation in a Mouse Model of Type-2 Diabetes Induced by Cafeteria-Style Diet and Low-Doses of Streptozotocin
Published in Frontiers in pharmacology (03-02-2021)“…Painful distal symmetrical polyneuropathy (DPN) is a frequent complication of type-2 diabetes mellitus (T2DM) that commonly presents as neuropathic pain and…”
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Repeated administration of mazindol reduces spontaneous pain-related behaviors without modifying bone density and microarchitecture in a mouse model of complete Freund's adjuvant-induced knee arthritis
Published in Journal of pain research (01-01-2017)“…The role of dopaminergic system in the development of rheumatoid arthritis-related pain, a major symptom in this disease, has not been explored. Therefore, the…”
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Streptozocin-induced type-1 diabetes mellitus results in decreased density of CGRP sensory and TH sympathetic nerve fibers that are positively correlated with bone loss at the mouse femoral neck
Published in Neuroscience letters (10-08-2017)“…•Type-1 DM decreases the density of CGRP and TH nerve fibers in the mouse femur.•Type-1 DM negatively alters the trabecular bone at the mouse femoral…”
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Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3–dependent sensitization
Published in Pain (Amsterdam) (01-08-2022)“…Several bone conditions, eg, bone cancer, osteoporosis, and rheumatoid arthritis (RA), are associated with a risk of developing persistent pain. Increased…”
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Sex-dependent effects of the targeted nerve growth factor mutation (R100E) on pain behavior, joint inflammation, and bone erosion in mice
Published in Pain (Amsterdam) (01-12-2024)“…Nerve growth factor (NGF)-R100E is a mutated form of human recombinant NGF that reduces the binding of NGF to its p75NTR receptor while retaining its affinity…”
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Insights into FcγR involvement in pain-like behavior induced by an RA-derived anti-modified protein autoantibody
Published in Brain, behavior, and immunity (01-10-2023)“…•Transfer of RA antibody (B09) to mice induces painwithout joint inflammation.•B09 is retained in the dorsal root ganglia where it binds satellite glia…”
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Sex-dependent effects of the targeted NGF mutation (R100E) on pain behavior, joint inflammation, and bone erosion in mice
Published in Pain (Amsterdam) (25-09-2024)“…Nerve growth factor (NGF)-R100E is a mutated form of human recombinant NGF that reduces the binding of NGF to its p75NTR receptor while retaining its affinity…”
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