Search Results - "Martínez de Morentin, Pablo B."

Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase by MARTINEZ DE MORENTIN, Pablo B, WHITTLE, Andrew J, FERNØ, Johan, NOGUEIRAS, Ruben, DIEGUEZ, Carlos, VIDAL-PUIG, Antonio, LOPEZ, Miguel

“…Smokers around the world commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. Numerous…”
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Nicotine Improves Obesity and Hepatic Steatosis and ER Stress in Diet-Induced Obese Male Rats by Seoane-Collazo, Patricia, de Morentin, Pablo B. Martínez, Fernø, Johan, Diéguez, Carlos, Nogueiras, Rubén, López, Miguel

“…Nicotine, the main addictive component of tobacco, promotes body weight reduction in humans and rodents. Recent evidence has suggested that nicotine acts in…”
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Pregnancy Induces Resistance to the Anorectic Effect of Hypothalamic Malonyl-CoA and the Thermogenic Effect of Hypothalamic AMPK Inhibition in Female Rats by Martínez de Morentin, Pablo B, Lage, Ricardo, González-García, Ismael, Ruíz-Pino, Francisco, Martins, Luís, Fernández-Mallo, Diana, Gallego, Rosalía, Fernø, Johan, Señarís, Rosa, Saha, Asish K, Tovar, Sulay, Diéguez, Carlos, Nogueiras, Rubén, Tena-Sempere, Manuel, López, Miguel

“…During gestation, hyperphagia is necessary to cope with the metabolic demands of embryonic development. There were three main aims of this study: Firstly, to…”
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Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK by Martínez de Morentin, Pablo B., González-García, Ismael, Martins, Luís, Lage, Ricardo, Fernández-Mallo, Diana, Martínez-Sánchez, Noelia, Ruíz-Pino, Francisco, Liu, Ji, Morgan, Donald A., Pinilla, Leonor, Gallego, Rosalía, Saha, Asish K., Kalsbeek, Andries, Fliers, Eric, Bisschop, Peter H., Diéguez, Carlos, Nogueiras, Rubén, Rahmouni, Kamal, Tena-Sempere, Manuel, López, Miguel

“…Estrogens play a major role in the modulation of energy balance through central and peripheral actions. Here, we demonstrate that central action of estradiol…”
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Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress by González-García, Ismael, Contreras, Cristina, Estévez-Salguero, Ánxela, Ruíz-Pino, Francisco, Colsh, Benoit, Pensado, Iván, Liñares-Pose, Laura, Rial-Pensado, Eva, Martínez de Morentin, Pablo B., Fernø, Johan, Diéguez, Carlos, Nogueiras, Rubén, Le Stunff, Hervé, Magnan, Christophe, Tena-Sempere, Manuel, López, Miguel

“…Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the…”
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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance by Martínez-Sánchez, Noelia, Seoane-Collazo, Patricia, Contreras, Cristina, Varela, Luis, Villarroya, Joan, Rial-Pensado, Eva, Buqué, Xabier, Aurrekoetxea, Igor, Delgado, Teresa C., Vázquez-Martínez, Rafael, González-García, Ismael, Roa, Juan, Whittle, Andrew J., Gomez-Santos, Beatriz, Velagapudi, Vidya, Tung, Y.C. Loraine, Morgan, Donald A., Voshol, Peter J., Martínez de Morentin, Pablo B., López-González, Tania, Liñares-Pose, Laura, Gonzalez, Francisco, Chatterjee, Krishna, Sobrino, Tomás, Medina-Gómez, Gema, Davis, Roger J., Casals, Núria, Orešič, Matej, Coll, Anthony P., Vidal-Puig, Antonio, Mittag, Jens, Tena-Sempere, Manuel, Malagón, María M., Diéguez, Carlos, Martínez-Chantar, María Luz, Aspichueta, Patricia, Rahmouni, Kamal, Nogueiras, Rubén, Sabio, Guadalupe, Villarroya, Francesc, López, Miguel

“…Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid…”
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Hyperthyroidism differentially regulates neuropeptide S system in the rat brain by González, Carmen R, Martínez de Morentin, Pablo B, Martínez-Sánchez, Noelia, Gómez-Díaz, Consuelo, Lage, Ricardo, Varela, Luis, Diéguez, Carlos, Nogueiras, Rubén, Castaño, Justo P, López, Miguel

“…Abstract Thyroid hormones play an important role in the regulation of energy balance, sleep and emotional behaviors. Neuropeptide S (NPS) is a recently…”
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Editorial: Role of estrogens as key regulators of energy homeostasis by Novelle, Marta G., Camacho-Morales, Alberto, Martínez De Morentin, Pablo B.

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Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression by Wagner, Stefan, Brierley, Daniel I., Leeson-Payne, Alasdair, Jiang, Wanqing, Chianese, Raffaella, Lam, Brian Y.H., Dowsett, Georgina K.C., Cristiano, Claudia, Lyons, David, Reimann, Frank, Gribble, Fiona M., Martinez de Morentin, Pablo B., Yeo, Giles S.H., Trapp, Stefan, Heisler, Lora K.

“…Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include…”
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Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons by Burke, Luke K, Doslikova, Barbora, D'Agostino, Giuseppe, Greenwald-Yarnell, Megan, Georgescu, Teodora, Chianese, Raffaella, Martinez de Morentin, Pablo B, Ogunnowo-Bada, Emmanuel, Cansell, Celine, Valencia-Torres, Lourdes, Garfield, Alastair S, Apergis-Schoute, John, Lam, Daniel D, Speakman, John R, Rubinstein, Marcelo, Low, Malcolm J, Rochford, Justin J, Myers, Martin G, Evans, Mark L, Heisler, Lora K

“…Abstract Objective Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated…”
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A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding by Martinez de Morentin, Pablo B, Gonzalez, J Antonio, Dowsett, Georgina K C, Martynova, Yuliia, Yeo, Giles S H, Sylantyev, Sergiy, Heisler, Lora K

“…The obesity epidemic is principally driven by the consumption of more calories than the body requires. It is therefore essential that the mechanisms…”
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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function by Yavari, Arash, Stocker, Claire J., Ghaffari, Sahar, Wargent, Edward T., Steeples, Violetta, Czibik, Gabor, Pinter, Katalin, Bellahcene, Mohamed, Woods, Angela, Martínez de Morentin, Pablo B., Cansell, Céline, Lam, Brian Y.H., Chuster, André, Petkevicius, Kasparas, Nguyen-Tu, Marie-Sophie, Martinez-Sanchez, Aida, Pullen, Timothy J., Oliver, Peter L., Stockenhuber, Alexander, Nguyen, Chinh, Lazdam, Merzaka, O’Dowd, Jacqueline F., Harikumar, Parvathy, Tóth, Mónika, Beall, Craig, Kyriakou, Theodosios, Parnis, Julia, Sarma, Dhruv, Katritsis, George, Wortmann, Diana D.J., Harper, Andrew R., Brown, Laurence A., Willows, Robin, Gandra, Silvia, Poncio, Victor, de Oliveira Figueiredo, Márcio J., Qi, Nathan R., Peirson, Stuart N., McCrimmon, Rory J., Gereben, Balázs, Tretter, László, Fekete, Csaba, Redwood, Charles, Yeo, Giles S.H., Heisler, Lora K., Rutter, Guy A., Smith, Mark A., Withers, Dominic J., Carling, David, Sternick, Eduardo B., Arch, Jonathan R.S., Cawthorne, Michael A., Watkins, Hugh, Ashrafian, Houman

“…Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge…”
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mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol by González-García, Ismael, Martínez de Morentin, Pablo B, Estévez-Salguero, Ánxela, Contreras, Cristina, Romero-Picó, Amparo, Fernø, Johan, Nogueiras, Rubén, Diéguez, Carlos, Tena-Sempere, Manuel, Tovar, Sulay, López, Miguel

“…Current evidence suggests that estradiol (E2), the main ovarian steroid, modulates energy balance by regulating both feeding and energy expenditure at the…”
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Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation by Leeson-Payne, Alasdair, Iyinikkel, Jean, Malcolm, Cameron, Lam, Brian Y H, Sommer, Nadine, Dowsett, Georgina K C, Martinez de Morentin, Pablo B, Thompson, Dawn, Mackenzie, Alasdair, Chianese, Raffaella, Kentistou, Katherine, Gardner, Eugene J, Perry, John R B, Grassmann, Felix, Speakman, John R, Rochford, Justin J, Yeo, Giles S H, Murray, Fiona, Heisler, Lora K

“…Approximately 1 in 4 people worldwide have non-alcoholic fatty liver disease (NAFLD); however, there are currently no medications to treat this condition. This…”
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Molecular mechanisms of appetite and obesity: a role for brain AMPK by Martínez de Morentin, Pablo B, Urisarri, Adela, Couce, María L, López, Miguel

“…Feeding behaviour and energy storage are both crucial aspects of survival. Thus, it is of fundamental importance to understand the molecular mechanisms…”
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Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome by McKay, Eleanor J., Luijten, Ineke, Weng, Xiong, Martinez de Morentin, Pablo B., De Frutos González, Elvira, Gao, Zhanguo, Kolonin, Mikhail G., Heisler, Lora K., Semple, Robert K.

“…Alström Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty…”
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New insights in ghrelin orexigenic effect by Diéguez, Carlos, Da Boit, Kátia, Novelle, Marta G, Martínez de Morentin, Pablo B, Nogueiras, Rubén, López, Miguel

“…Ghrelin, a peptide hormone first discovered as the endogenous ligand of the growth hormone secretagogue receptor (GHS-R), is predominantly produced and…”
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Hypothalamic lipotoxicity and the metabolic syndrome by Martínez de Morentin, Pablo B., Varela, Luis, Fernø, Johan, Nogueiras, Rubén, Diéguez, Carlos, López, Miguel

“…Ectopic accumulation of lipids in peripheral tissues, such as pancreatic β cells, liver, heart and skeletal muscle, leads to lipotoxicity, a process that…”
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Lorcaserin improves glycemic control via a melanocortin neurocircuit by Burke, Luke K., Ogunnowo-Bada, Emmanuel, Georgescu, Teodora, Cristiano, Claudia, de Morentin, Pablo B. Martinez, Valencia Torres, Lourdes, D'Agostino, Giuseppe, Riches, Christine, Heeley, Nicholas, Ruan, Yue, Rubinstein, Marcelo, Low, Malcolm J., Myers, Martin G., Rochford, Justin J., Evans, Mark L., Heisler, Lora K.

“…The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the…”
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Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5‐HT2C receptor heteromers in mouse brain by Gerbier, Romain, Ndiaye‐Lobry, Delphine, Martinez de Morentin, Pablo B., Cecon, Erika, Heisler, Lora K., Delagrange, Philippe, Gbahou, Florence, Jockers, Ralf

“…Association of G protein‐coupled receptors into heterodimeric complexes has been reported for over 50 receptor pairs in vitro but functional in vivo validation…”
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