Search Results - "Martínez, Ernesto"

The detrimental role of galectin‐3 and endoplasmic reticulum stress in the cardiac consequences of myocardial ischemia in the context of obesity by Jiménez‐González, Sara, Delgado‐Valero, Beatriz, Islas, Fabian, Romero‐Miranda, Ana, Luaces, María, Ramchandani, Bunty, Cuesta‐Corral, María, Montoro‐Garrido, Alejandro, Martínez‐Martínez, Ernesto, Cachofeiro, Victoria

“…The association between cardiac fibrosis and galectin‐3 was evaluated in patients with acute myocardial infarction (MI). The role of galectin‐3 and its…”
Get full text

Microsomal prostaglandin E synthase‐1 is involved in the metabolic and cardiovascular alterations associated with obesity by Ballesteros‐Martínez, Constanza, Rodrigues‐Díez, Raquel, Beltrán, Luis M., Moreno‐Carriles, Rosa, Martínez‐Martínez, Ernesto, González‐Amor, María, Martínez‐González, Jose, Rodríguez, Cristina, Cachofeiro, Victoria, Salaices, Mercedes, Briones, Ana M.

“…Background and Purpose Microsomal prostaglandin E synthase‐1 (mPGES‐1) is an inducible isomerase responsible for prostaglandin E2 production in inflammatory…”
Get full text

Galectin-3 Blockade Inhibits Cardiac Inflammation and Fibrosis in Experimental Hyperaldosteronism and Hypertension by Martínez-Martínez, Ernesto, Calvier, Laurent, Fernández-Celis, Amaya, Rousseau, Elodie, Jurado-López, Raquel, Rossoni, Luciana V, Jaisser, Frederic, Zannad, Faiez, Rossignol, Patrick, Cachofeiro, Victoria, López-Andrés, Natalia

“…Hypertensive cardiac remodeling is accompanied by molecular inflammation and fibrosis, 2 mechanisms that finally affect cardiac function. At cardiac level,…”
Get full text

The role of mitochondrial oxidative stress in the metabolic alterations in diet‐induced obesity in rats by Marín‐Royo, Gema, Rodríguez, Cristina, Pape, Aliaume Le, Jurado‐Lopez, Raquel, Luaces, María, Antequera, Alfonso, Martínez‐Gonzalez, Jose, Souza‐Neto, Francisco V., Nieto, María Luisa, Martínez‐Martínez, Ernesto, Cachofeiro, Victoria

“…The impact of the mitochondria‐targeted antioxidant MitoQ was evaluated in the metabolic alterations and the adipose tissue remodeling associated with obesity…”
Get full text

Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved by Delgado-Valero, Beatriz, Cachofeiro, Victoria, Martínez-Martínez, Ernesto

“…Cardiorenal syndrome is a term that defines the complex bidirectional nature of the interaction between cardiac and renal disease. It is well established that…”
Get full text

Aldosterone Target NGAL (Neutrophil Gelatinase–Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NFκB Pathway by Martínez-Martínez, Ernesto, Buonafine, Mathieu, Boukhalfa, Ines, Ibarrola, Jaime, Fernández-Celis, Amaya, Kolkhof, Peter, Rossignol, Patrick, Girerd, Nicolas, Mulder, Paul, López-Andrés, Natalia, Ouvrard-Pascaud, Antoine, Jaisser, Frédéric

“…Myocardial infarction (MI) is accompanied by cardiac fibrosis, which contributes to cardiac dysfunction. Mineralocorticoid receptor (MR) antagonists have…”
Get full text

Unexpected Photodegradation of a Phosphaketenyl‐Substituted Germyliumylidene Borate Complex by Xiong, Yun, Yao, Shenglai, Szilvási, Tibor, Ballestero‐Martínez, Ernesto, Grützmacher, Hansjörg, Driess, Matthias

“…The first zwitterionic borata‐bis(NHC)‐stabilized phosphaketenyl germyliumylidene [(L2(O=C=P)Ge:] 2 (L2=(p‐tolyl)2B[1‐(1‐adamantyl)‐3‐yl‐2‐ylidene]2) has been…”
Get full text

Oxidative Stress in Obesity by Martínez-Martínez, Ernesto, Cachofeiro, Victoria

“…Obesity is defined by the World Health Organization (WHO) as abnormal or excessive fat accumulation that presents a health risk [...]…”
Get full text

Galectin-3 pharmacological inhibition attenuates early renal damage in spontaneously hypertensive rats by Martínez-Martínez, Ernesto, Ibarrola, Jaime, Fernández-Celis, Amaya, Calvier, Laurent, Leroy, Celine, Cachofeiro, Victoria, Rossignol, Patrick, López-Andrés, Natalia

“…The pharmacological blockade of galectin-3 (Gal-3), a β-galactoside-binding lectin, reduces renal impairment in acute kidney injury, hyperaldosteronism or…”
Get full text

CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation: Mechanistic Insights and Clinical Implications by Martínez-Martínez, Ernesto, Brugnolaro, Cristina, Ibarrola, Jaime, Ravassa, Susana, Buonafine, Mathieu, López, Begoña, Fernández-Celis, Amaya, Querejeta, Ramón, Santamaria, Enrique, Fernández-Irigoyen, Joaquín, Rábago, Gregorio, Moreno, María U, Jaisser, Frédéric, Díez, Javier, González, Arantxa, López-Andrés, Natalia

“…Myocardial fibrosis is a main contributor to the development of heart failure (HF). CT-1 (cardiotrophin-1) and Gal-3 (galectin-3) are increased in HF and…”
Get full text

Role for Galectin‐3 in Calcific Aortic Valve Stenosis by Sádaba, J. Rafael, Martínez‐Martínez, Ernesto, Arrieta, Vanessa, Álvarez, Virginia, Fernández‐Celis, Amaya, Ibarrola, Jaime, Melero, Amaia, Rossignol, Patrick, Cachofeiro, Victoria, López‐Andrés, Natalia

“…Background Aortic stenosis (AS) is a chronic inflammatory disease, and calcification plays an important role in the progression of the disease. Galectin‐3…”
Get full text

Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition by Ibarrola, Jaime, Matilla, Lara, Martínez-Martínez, Ernesto, Gueret, Alexandre, Fernández-Celis, Amaya, Henry, Jean-Paul, Nicol, Lionel, Jaisser, Frederic, Mulder, Paul, Ouvrard-Pascaud, Antoine, López-Andrés, Natalia

“…Although optimal therapy for myocardial infarction includes reperfusion to restore blood flow to the ischemic region, ischemia/reperfusion (IR) also initiates…”
Get full text

Facile Access to NaOC≡As and Its Use as an Arsenic Source To Form Germylidenylarsinidene Complexes by Yao, Shenglai, Grossheim, Yves, Kostenko, Arseni, Ballestero‐Martínez, Ernesto, Schutte, Stefan, Bispinghoff, Mark, Grützmacher, Hansjörg, Driess, Matthias

“…A facile, one‐pot synthesis of [Na(OC≡As)(dioxane)x] (x=2.3–3.3) in 78 % yield is reported through the reaction of arsine gas with dimethylcarbonate in the…”
Get full text

Neutrophil Gelatinase-Associated Lipocalin from immune cells is mandatory for aldosterone-induced cardiac remodeling and inflammation by Buonafine, Mathieu, Martínez-Martínez, Ernesto, Amador, Cristian, Gravez, Basile, Ibarrola, Jaime, Fernández-Celis, Amaya, El Moghrabi, Soumaya, Rossignol, Patrick, López-Andrés, Natalia, Jaisser, Frédéric

“…Immune system activation is involved in cardiovascular (CV) inflammation and fibrosis, following activation of the mineralocorticoid receptor (MR). We…”
Get full text

A Bayesian Approach to Run-to-Run Optimization of Animal Cell Bioreactors Using Probabilistic Tendency Models by Luna, Martin, Martínez, Ernesto

“…Increasing demand for recombinant proteins (including monoclonal antibodies) where time to market is critical could benefit from the use of model-based…”
Get full text

End-to-end on-line rescheduling from Gantt chart images using deep reinforcement learning by Palombarini, Jorge Andrés, Martínez, Ernesto Carlos

“…With the advent of the socio-technical manufacturing paradigm, the way in which rescheduling decisions are taken at the shop floor has radically changed in…”
Get full text

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial by López-Medina, Eduardo, López, Pío, Hurtado, Isabel C, Dávalos, Diana M, Ramirez, Oscar, Martínez, Ernesto, Díazgranados, Jesus A, Oñate, José M, Chavarriaga, Hector, Herrera, Sócrates, Parra, Beatriz, Libreros, Gerardo, Jaramillo, Roberto, Avendaño, Ana C, Toro, Dilian F, Torres, Miyerlandi, Lesmes, Maria C, Rios, Carlos A, Caicedo, Isabella

“…IMPORTANCE: Ivermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinical benefit. OBJECTIVE: To determine…”
Get full text

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin by Martínez-Martínez, Ernesto, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, Nieto, María Luisa, Bravo-San Pedro, José Manuel, Cachofeiro, Victoria

“…A proteomic approach was used to characterize potential mediators involved in the improvement in cardiac fibrosis observed with the administration of the…”
Get full text

Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest by Martínez-Martínez, Ernesto, Souza-Neto, Francisco V, Jiménez-González, Sara, Cachofeiro, Victoria

“…The vascular system plays a central role in the transport of cells, oxygen and nutrients between different regions of the body, depending on the needs, as well…”
Get full text

Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress: potential role in obesity by Martínez-Martínez, Ernesto, Jurado-López, Raquel, Valero-Muñoz, María, Bartolomé, María Visitación, Ballesteros, Sandra, Luaces, María, Briones, Ana María, López-Andrés, Natalia, Miana, María, Cachofeiro, Victoria

“…OBJECTIVE:Leptin acts as a cardiac profibrotic factor. However, the mechanisms underlying this effect are unclear. Therefore, we sought to elucidate the…”
Get full text