Search Results - "Martín‐Subero, José I."

Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer by Kulis, Marta, Queirós, Ana C., Beekman, Renée, Martín-Subero, José I.

“…Ever since the discovery of DNA methylation at cytosine residues, the role of this so called fifth base has been extensively studied and debated. Until…”
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Whole-genome fingerprint of the DNA methylome during human B cell differentiation by Kulis, Marta, Merkel, Angelika, Heath, Simon, Queirós, Ana C, Schuyler, Ronald P, Castellano, Giancarlo, Beekman, Renée, Raineri, Emanuele, Esteve, Anna, Clot, Guillem, Verdaguer-Dot, Néria, Duran-Ferrer, Martí, Russiñol, Nuria, Vilarrasa-Blasi, Roser, Ecker, Simone, Pancaldi, Vera, Rico, Daniel, Agueda, Lidia, Blanc, Julie, Richardson, David, Clarke, Laura, Datta, Avik, Pascual, Marien, Agirre, Xabier, Prosper, Felipe, Alignani, Diego, Paiva, Bruno, Caron, Gersende, Fest, Thierry, Muench, Marcus O, Fomin, Marina E, Lee, Seung-Tae, Wiemels, Joseph L, Valencia, Alfonso, Gut, Marta, Flicek, Paul, Stunnenberg, Hendrik G, Siebert, Reiner, Küppers, Ralf, Gut, Ivo G, Campo, Elías, Martín-Subero, José I

“…José Martín-Subero and colleagues report the whole-genome bisulfite sequencing of ten blood cell subpopulations representing the cellular stages during B cell…”
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NF-κB activation impairs somatic cell reprogramming in ageing by Soria-Valles, Clara, Osorio, Fernando G., Gutiérrez-Fernández, Ana, De Los Angeles, Alejandro, Bueno, Clara, Menéndez, Pablo, Martín-Subero, José I., Daley, George Q., Freije, José M. P., López-Otín, Carlos

“…Ageing constitutes a critical impediment to somatic cell reprogramming. We have explored the regulatory mechanisms that constitute age-associated barriers,…”
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Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients by Fernández‐Santiago, Rubén, Carballo‐Carbajal, Iria, Castellano, Giancarlo, Torrent, Roger, Richaud, Yvonne, Sánchez‐Danés, Adriana, Vilarrasa‐Blasi, Roser, Sánchez‐Pla, Alex, Mosquera, José Luis, Soriano, Jordi, López‐Barneo, José, Canals, Josep M, Alberch, Jordi, Raya, Ángel, Vila, Miquel, Consiglio, Antonella, Martín‐Subero, José I, Ezquerra, Mario, Tolosa, Eduardo

“…The epigenomic landscape of Parkinson's disease (PD) remains unknown. We performed a genomewide DNA methylation and a transcriptome studies in induced…”
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Identification of two unannotated miRNAs in classic Hodgkin lymphoma cell lines by Ustaszewski, Adam, Paczkowska, Julia, Janiszewska, Joanna, Bernhart, Stephan H, Bein, Julia, Russiñol, Núria, Hansmann, Martin-Leo, Chapaprieta, Vicente, Martín-Subero, José I, Siebert, Reiner, Hartmann, Sylvia, Giefing, Maciej

“…MicroRNAs (miRNAs) are small non coding RNAs responsible for posttranscriptional regulation of gene expression. Even though almost 2000 precursors have been…”
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Landscape and clinical significance of long noncoding RNAs involved in multiple myeloma expressed fusion transcripts by Amundarain, Ane, Valcárcel, Luis V., Ordoñez, Raquel, Garate, Leire, Miranda, Estíbaliz, Cendoya, Xabier, Carrasco‐Leon, Arantxa, Calasanz, María José, Paiva, Bruno, Meydan, Cem, Mason, Christopher E., Melnick, Ari, Rodriguez‐Otero, Paula, Martín‐Subero, José I., San Miguel, Jesús, Planes, Francisco J., Prósper, Felipe, Agirre, Xabier

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Differential expression of long non‐coding RNAs are related to proliferation and histological diversity in follicular lymphomas by Roisman, Alejandro, Castellano, Giancarlo, Navarro, Alba, Gonzalez‐Farre, Blanca, Pérez‐Galan, Patricia, Esteve‐Codina, Anna, Dabad, Marc, Heath, Simon, Gut, Marta, Bosio, Mattia, Bellot, Pau, Salembier, Philippe, Oliveras, Albert, Slavutsky, Irma, Magnano, Laura, Horn, Heike, Rosenwald, Andreas, Ott, German, Aymerich, Marta, López‐Guillermo, Armando, Jares, Pedro, Martín‐Subero, José I., Campo, Elías, Hernández, Luis

“…Summary Long non‐coding RNAs (lncRNAs) comprise a family of non‐coding transcripts that are emerging as relevant gene expression regulators of different…”
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Clinical features of maternal uniparental disomy 14 in patients with an epimutation and a deletion of the imprinted DLK1/GTL2 gene cluster by Buiting, Karin, Kanber, Deniz, Martín‐Subero, José I., Lieb, Wolfgang, Terhal, Paulien, Albrecht, Beate, Purmann, Sabine, Gross, Stephanie, Lich, Christina, Siebert, Reiner, Horsthemke, Bernhard, Gillessen‐Kaesbach, Gabriele

“…Maternal uniparental disomy 14 [upd(14)mat] is associated with a recognizable phenotype that includes pre‐ and postnatal growth retardation, neonatal…”
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Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications by Vegliante, Maria Carmela, Royo, Cristina, Palomero, Jara, Salaverria, Itziar, Balint, Balazs, Martín-Guerrero, Idoia, Agirre, Xabier, Lujambio, Amaia, Richter, Julia, Xargay-Torrent, Silvia, Bea, Silvia, Hernandez, Luis, Enjuanes, Anna, Calasanz, María José, Rosenwald, Andreas, Ott, German, Roman-Gomez, José, Prosper, Felipe, Esteller, Manel, Jares, Pedro, Siebert, Reiner, Campo, Elias, Martín-Subero, José I, Amador, Virginia

“…Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such…”
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IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics by Nadeu, Ferran, Royo, Romina, Clot, Guillem, Duran-Ferrer, Martí, Navarro, Alba, Martín, Silvia, Lu, Junyan, Zenz, Thorsten, Baumann, Tycho, Jares, Pedro, Puente, Xose S., Martín-Subero, José I., Delgado, Julio, Campo, Elías

“…B-cell receptor (BCR) signaling is crucial for chronic lymphocytic leukemia (CLL) biology. IGLV3-21–expressing B cells may acquire a single point mutation…”
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DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis by Mayol, Gemma, Martín-Subero, José I, Ríos, José, Queiros, Ana, Kulis, Marta, Suñol, Mariona, Esteller, Manel, Gómez, Soledad, Garcia, Idoia, de Torres, Carmen, Rodríguez, Eva, Galván, Patricia, Mora, Jaume, Lavarino, Cinzia

“…Neuroblastoma (NB) pathogenesis has been reported to be closely associated with numerous genetic alterations. However, underlying DNA methylation patterns have…”
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DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights by Gómez, Soledad, Castellano, Giancarlo, Mayol, Gemma, Suñol, Mariona, Queiros, Ana, Bibikova, Marina, Nazor, Kristopher L, Loring, Jeanne F, Lemos, Isadora, Rodríguez, Eva, de Torres, Carmen, Mora, Jaume, Martín-Subero, José I, Lavarino, Cinzia

“…To define the DNA methylation landscape of neuroblastoma and its clinicopathological impact. Microarray DNA methylation data were analyzed and associated with…”
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A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions by Grossi, Elena, Raimondi, Ivan, Goñi, Enrique, González, Jovanna, Marchese, Francesco P., Chapaprieta, Vicente, Martín-Subero, José I., Guo, Shuling, Huarte, Maite

“…LncRNAs have been shown to be direct players in chromatin regulation, but little is known about their role at active genomic loci. We investigate the role of…”
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Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies by Fraga, Mario F, Berdasco, Maria, Ballestar, Esteban, Ropero, Santiago, Lopez-Nieva, Pilar, Lopez-Serra, Lidia, Martín-Subero, José I, Calasanz, Maria J, Lopez de Silanes, Isabel, Setien, Fernando, Casado, Sara, Fernandez, Agustin F, Siebert, Reiner, Stifani, Stefano, Esteller, Manel

“…An undifferentiated status and the epigenetic inactivation of tumor-suppressor genes are hallmarks of transformed cells. Promoter CpG island hypermethylation…”
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Array-based DNA methylation profiling of primary lymphomas of the central nervous system by Richter, Julia, Ammerpohl, Ole, Martín-Subero, José I, Montesinos-Rongen, Manuel, Bibikova, Marina, Wickham-Garcia, Eliza, Wiestler, Otmar D, Deckert, Martina, Siebert, Reiner

“…Although primary lymphomas of the central nervous system (PCNSL) and extracerebral diffuse large B-cell lymphoma (DLBCL) cannot be distinguished…”
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Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2 by Joos, Stefan, Granzow, Martin, Holtgreve‐Grez, Heidi, Siebert, Reiner, Harder, Lana, Martín‐Subero, José I., Wolf, Jürgen, Adamowicz, Martyna, Barth, Thomas F.E., Lichter, Peter, Jauch, Anna

“…Four Hodgkin's lymphoma cell lines (KM‐H2, HDLM‐2, L428, L1236) were analyzed for cytogenetic aberrations, applying multiplex fluorescence in situ…”
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Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice by Fraile, Julia M., Campos-Iglesias, Diana, Rodríguez, Francisco, Astudillo, Aurora, Vilarrasa-Blasi, Roser, Verdaguer-Dot, Nuria, Prado, Miguel A., Paulo, Joao A., Gygi, Steven P., Martín-Subero, José I., Freije, José M.P., López-Otín, Carlos

“…Deubiquitinases are proteases with a wide functional diversity that profoundly impact multiple biological processes. Among them, the ubiquitin-specific…”
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The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes by Subtil-Rodríguez, Alicia, Vázquez-Chávez, Elena, Ceballos-Chávez, María, Rodríguez-Paredes, Manuel, Martín-Subero, José I, Esteller, Manel, Reyes, José C

“…The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repressive chromatin configuration mediated by the retinoblastoma…”
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Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics by Speedy, Helen E., Beekman, Renée, Chapaprieta, Vicente, Orlando, Giulia, Law, Philip J., Martín-García, David, Gutiérrez-Abril, Jesús, Catovsky, Daniel, Beà, Sílvia, Clot, Guillem, Puiggròs, Montserrat, Torrents, David, Puente, Xose S., Allan, James M., López-Otín, Carlos, Campo, Elias, Houlston, Richard S., Martín-Subero, José I.

“…Genome-wide association studies have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the…”
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DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights by Gómez, Soledad, Castellano, Giancarlo, Mayol, Gemma, Queiros, Ana, Martín-Subero, José I., Lavarino, Cinzia

“…Neuroblastoma (NB) is one of the most frequently occurring extracranial solid tumors of childhood (Maris et al., 2007 [1]; Brodeur, 2003 [2]). Probability of…”
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