Effectiveness of opioid rotation in the control of cancer pain: the ROTODOL study

To assess the effectiveness of opioid rotation (OR) to manage cancer pain. To describe the adverse events (AEs) associated with OR. Thirty-nine tertiary hospital services. Sixty-seven oncological patients with cancer-related pain treated at outpatient clinics. Prospective multicenter study. Pain int...

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Bibliographic Details
Published in:	Journal of opioid management Vol. 10; no. 6; p. 395
Main Authors:	González-Barboteo, Jesús, Alentorn, Xavier Gómez-Batiste, Manuel, Felipe A Calvo, Candel, Vicente Alberola, Eito, M Amalia Palacios, Sánchez-Magro, Isabel, Álvarez, Marta Neira, Martín, F Javier Pérez, Porta-Sales, Josep
Format:	Journal Article
Language:	English
Published:	United States 01-11-2014
Subjects:	Adult Aged Aged, 80 and over Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Breakthrough Pain - diagnosis Breakthrough Pain - drug therapy Breakthrough Pain - etiology Chronic Pain - diagnosis Chronic Pain - drug therapy Chronic Pain - etiology Drug Administration Schedule Drug Substitution Female Humans Male Middle Aged Neoplasms - complications Pain Measurement Prospective Studies Severity of Illness Index Spain Tertiary Care Centers Time Factors Treatment Outcome Spain
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Summary:	To assess the effectiveness of opioid rotation (OR) to manage cancer pain. To describe the adverse events (AEs) associated with OR. Thirty-nine tertiary hospital services. Sixty-seven oncological patients with cancer-related pain treated at outpatient clinics. Prospective multicenter study. Pain intensity was scored using a Numerical Rating Scale (NRS) of 0-10. Average pain (AP) intensity in the last 24 hours, breakthrough pain (BTP), and the number of episodes of BTP on the days before and 1 week after OR were assessed. The pre-OR and post-OR opioid were recorded. The presence and intensity of any AEs occurring after OR were also recorded. In the 67 patients evaluated, 75 ORs were recorded. In all cases, the main reason for OR was poor pain control. Pain intensity decreased by ≥2 points after OR in 75.4 percent and 57.8 percent of cases for AP and BTP, respectively. If the initial NRS score was ≥4, a decrease below <4 accounted for 50.9 percent and 32.3 percent of cases for AP and BTP, respectively. The number of episodes of BTP also decreased significantly (p<0.001). A total of 107 AEs were reported, most of which were mild in intensity, with gastrointestinal symptoms predominating. Opioid rotation appears to be both safe and effective in the management of basal and breakthrough cancer pain.
ISSN:	1551-7489
DOI:	10.5055/jom.2014.0236