Search Results - "Martí, Àlex"

Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial by Provencio, Mariano, Nadal, Ernest, Insa, Amelia, García-Campelo, María Rosario, Casal-Rubio, Joaquín, Dómine, Manuel, Majem, Margarita, Rodríguez-Abreu, Delvys, Martínez-Martí, Alex, De Castro Carpeño, Javier, Cobo, Manuel, López Vivanco, Guillermo, Del Barco, Edel, Bernabé Caro, Reyes, Viñolas, Nuria, Barneto Aranda, Isidoro, Viteri, Santiago, Pereira, Eva, Royuela, Ana, Casarrubios, Marta, Salas Antón, Clara, Parra, Edwin R, Wistuba, Ignacio, Calvo, Virginia, Laza-Briviesca, Raquel, Romero, Atocha, Massuti, Bartomeu, Cruz-Bermúdez, Alberto

“…Non-small-cell lung cancer (NSCLC) is terminal in most patients with locally advanced stage disease. We aimed to assess the antitumour activity and safety of…”
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Overall Survival and Biomarker Analysis of Neoadjuvant Nivolumab Plus Chemotherapy in Operable Stage IIIA Non-Small-Cell Lung Cancer (NADIM phase II trial) by Provencio, Mariano, Serna-Blasco, Roberto, Nadal, Ernest, Insa, Amelia, García-Campelo, M Rosario, Casal Rubio, Joaquín, Dómine, Manuel, Majem, Margarita, Rodríguez-Abreu, Delvys, Martínez-Martí, Alex, De Castro Carpeño, Javier, Cobo, Manuel, López Vivanco, Guillermo, Del Barco, Edel, Bernabé Caro, Reyes, Viñolas, Nuria, Barneto Aranda, Isidoro, Viteri, Santiago, Pereira, Eva, Royuela, Ana, Calvo, Virginia, Martín-López, Javier, García-García, Francisco, Casarrubios, Marta, Franco, Fernando, Sánchez-Herrero, Estela, Massuti, Bartomeu, Cruz-Bermúdez, Alberto, Romero, Atocha

“…Neoadjuvant chemotherapy plus nivolumab has been shown to be effective in resectable non-small-cell lung cancer (NSCLC) in the NADIM trial (ClinicalTrials.gov…”
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Perioperative Nivolumab and Chemotherapy in Stage III Non–Small-Cell Lung Cancer by Provencio, Mariano, Nadal, Ernest, González-Larriba, José L., Martínez-Martí, Alex, Bernabé, Reyes, Bosch-Barrera, Joaquim, Casal-Rubio, Joaquín, Calvo, Virginia, Insa, Amelia, Ponce, Santiago, Reguart, Noemí, de Castro, Javier, Mosquera, Joaquín, Cobo, Manuel, Aguilar, Andrés, López Vivanco, Guillermo, Camps, Carlos, López-Castro, Rafael, Morán, Teresa, Barneto, Isidoro, Rodríguez-Abreu, Delvys, Serna-Blasco, Roberto, Benítez, Raquel, Aguado de la Rosa, Carlos, Palmero, Ramón, Hernando-Trancho, Florentino, Martín-López, Javier, Cruz-Bermúdez, Alberto, Massuti, Bartomeu, Romero, Atocha

“…In patients with lung cancer, neoadjuvant treatment with nivolumab and chemotherapy resulted in a significantly higher percentage of patients with a…”
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Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition by Pereira, Carolina, Gimenez-Xavier, Pol, Pros, Eva, Pajares, Maria J, Moro, Massimo, Gomez, Antonio, Navarro, Alejandro, Condom, Enric, Moran, Sebastian, Gomez-Lopez, Gonzalo, Graña, Osvaldo, Rubio-Camarillo, Miriam, Martinez-Martí, Alex, Yokota, Jun, Carretero, Julian, Galbis, Jose M, Nadal, Ernest, Pisano, David, Sozzi, Gabriella, Felip, Enriqueta, Montuenga, Luis M, Roz, Luca, Villanueva, Alberto, Sanchez-Cespedes, Montse

“…We aimed to maximize the performance of detecting genetic alterations in lung cancer using high-throughput sequencing for patient-derived xenografts (PDXs). We…”
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Pretreatment Tissue TCR Repertoire Evenness Is Associated with Complete Pathologic Response in Patients with NSCLC Receiving Neoadjuvant Chemoimmunotherapy by Casarrubios, Marta, Cruz-Bermúdez, Alberto, Nadal, Ernest, Insa, Amelia, García Campelo, María Del Rosario, Lázaro, Martín, Dómine, Manuel, Majem, Margarita, Rodríguez-Abreu, Delvys, Martínez-Martí, Alex, de Castro-Carpeño, Javier, Cobo, Manuel, López-Vivanco, Guillermo, Del Barco, Edel, Bernabé Caro, Reyes, Viñolas, Nuria, Barneto Aranda, Isidoro, Viteri, Santiago, Massuti, Bartomeu, Barquín, Miguel, Laza-Briviesca, Raquel, Sierra-Rodero, Belén, Parra, Edwin R, Sanchez-Espiridion, Beatriz, Rocha, Pedro, Kadara, Humam, Wistuba, Ignacio I, Romero, Atocha, Calvo, Virginia, Provencio, Mariano

“…Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathologic response to immunotherapy in locally…”
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Perioperative chemotherapy and nivolumab in non-small-cell lung cancer (NADIM): 5-year clinical outcomes from a multicentre, single-arm, phase 2 trial by Provencio, Mariano, Nadal, Ernest, Insa, Amelia, García Campelo, Rosario, Casal, Joaquín, Dómine, Manuel, Massuti, Bartomeu, Majem, Margarita, Rodríguez-Abreu, Delvys, Martínez-Martí, Alex, de Castro, Javier, Gómez de Antonio, David, Macia, Iván, Figueroa, Santiago, Fernández Vago, Luís, Calvo, Virginia, Palmero, Ramón, Sierra-Rodero, Belén, Martínez-Toledo, Cristina, Molina-Alejandre, Marta, Serna-Blasco, Roberto, Romero, Atocha, Cruz-Bermúdez, Alberto

“…Perioperative immunotherapy improves short-term outcomes in resectable non-small-cell lung cancer (NSCLC). We now report 5-year survival from the NADIM trial…”
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BRAF mutational status is associated with survival outcomes in locally advanced resectable and metastatic NSCLC by Provencio, Mariano, Robado de Lope, Lucía, Serna-Blasco, Roberto, Nadal, Ernest, Diz Tain, Pilar, Massuti, Bartomeu, González-Larriba, José Luis, Insa, Amelia, Sánchez-Hernández, Alfredo, Casal-Rubio, Joaquín, García-Campelo, Rosario, Sequero López, Silvia, Rogado, Jacobo, Martínez-Martí, Alex, Bosch-Barrera, Joaquim, Bernabé, Reyes, Vázquez Estévez, Sergio, Ponce, Santiago, de Castro, Javier, Coves Sarto, Juan, Reguart, Noemí, Dómine, Manuel, Aguilar, Andrés, Majem, Margarita, Estival, Anna, Peña Cabia, Silvia, López Martín, Ana, Sala González, María Ángeles, Cobo, Manuel, Camps, Carlos, Barneto, Isidoro, Calvo, Virginia, Collazo-Lorduy, Ana, Cruz-Bermúdez, Alberto, Romero, Atocha

“…•Efficacy of ICIs in NSCLC patients with BRAF mutations remains uncertain.•Our data showed an increased pathological complete response rate in BRAF-mutant…”
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Front Cover: H‐Bonded Counterion‐Directed Catalysis: Enantioselective Gold(I)‐Catalyzed Addition to 2‐Alkynyl Enones as a Case Study (Eur. J. Org. Chem. 42/2022) by Martí, Àlex, Montesinos‐Magraner, Marc, Echavarren, Antonio M., Franchino, Allegra

“…The Front Cover illustrates the ability of the squaramide group to remove a chiral anionic ligand from Au(I) by H‐bonding interactions, by analogy with a…”
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Blood biomarkers associated to complete pathological response on NSCLC patients treated with neoadjuvant chemoimmunotherapy included in NADIM clinical trial by Laza‐Briviesca, Raquel, Cruz‐Bermúdez, Alberto, Nadal, Ernest, Insa, Amelia, García‐Campelo, María del Rosario, Huidobro, Gerardo, Dómine, Manuel, Majem, Margarita, Rodríguez‐Abreu, Delvys, Martínez‐Martí, Alex, De Castro Carpeño, Javier, Cobo, Manuel, López Vivanco, Guillermo, Del Barco, Edel, Bernabé Caro, Reyes, Viñolas, Nuria, Barneto Aranda, Isidoro, Viteri, Santiago, Massuti, Bartomeu, Casarrubios, Marta, Sierra‐Rodero, Belén, Tarín, Carlos, García‐Grande, Aránzazu, Haymaker, Cara, Wistuba, Ignacio I., Romero, Atocha, Franco, Fernando, Provencio, Mariano

“…Background Immunotherapy is being tested in early‐stage non‐small cell lung cancer (NSCLC), and achieving higher rates of complete pathological responses (CPR)…”
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H‑Bonded Counterion-Directed Enantioselective Au(I) Catalysis by Franchino, Allegra, Martí, Àlex, Echavarren, Antonio M

“…A new strategy for enantioselective transition-metal catalysis is presented, wherein a H-bond donor placed on the ligand of a cationic complex allows precise…”
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Hydrogen-Bonded Matched Ion Pair Gold(I) Catalysis by Martí, Àlex, Ogalla, Gala, Echavarren, Antonio M.

“…The enantioselective reaction of 1,6-enynes with O-, N-, and C-nucleophiles has been developed by matched ion pair gold­(I) catalysis in which the chiral…”
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Silver‐Free Au(I) Catalysis Enabled by Bifunctional Urea‐ and Squaramide‐Phosphine Ligands via H‐Bonding by Franchino, Allegra, Martí, Àlex, Nejrotti, Stefano, Echavarren, Antonio M.

“…A library of gold(I) chloride complexes with phosphine ligands incorporating pendant (thio)urea and squaramide H‐bond donors was prepared with the aim of…”
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1381-P: GDF15 Deficiency in Brown Adipose Tissue Does Not Affect Thermogenesis, but Exacerbates Diet-Induced Obesity by JENA, JAYASHREE, KATO, KEVIN, MARTI, ALEX A., PEREIRA, RENATA

“…Growth and differentiation factor 15 (GDF15) is induced in brown adipocytes in response to thermogenic stimuli, as well as high-fat feeding in mice. However,…”
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H-Bonded Counterion-Directed Catalysis: Enantioselective Gold(I)-Catalyzed Addition to 2-Alkynyl Enones as a Case Study by Martí, Àlex, Montesinos-Magraner, Marc, Echavarren, Antonio M, Franchino, Allegra

“…H-bonded counterion-directed catalysis (HCDC) is a strategy wherein a chiral anion that is hydrogen-bonded to the achiral ligand of a metal complex is…”
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OPA1 Regulates Lipid Metabolism and Cold-Induced Browning of White Adipose Tissue in Mice by Pereira, Renata O, Olvera, Angela C, Marti, Alex, Fang, Shi, White, Jeffrey R, Westphal, Michael, Hewezi, Rana, AshShareef, Salma T, García-Peña, Luis Miguel, Koneru, Jivan, Potthoff, Matthew J, Abel, E Dale

“…Mitochondria play a vital role in white adipose tissue (WAT) homeostasis including adipogenesis, fatty acid synthesis, and lipolysis. We recently reported that…”
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Molecular profiling of long‐term responders to immune checkpoint inhibitors in advanced non‐small cell lung cancer by Frigola, Joan, Navarro, Alejandro, Carbonell, Caterina, Callejo, Ana, Iranzo, Patricia, Cedrés, Susana, Martinez‐Marti, Alex, Pardo, Nuria, Saoudi‐Gonzalez, Nadia, Martinez, Debora, Jimenez, Jose, Sansano, Irene, Mancuso, Francesco M., Nuciforo, Paolo, Montuenga, Luis M., Sánchez‐Cespedes, Montse, Prat, Aleix, Vivancos, Ana, Felip, Enriqueta, Amat, Ramon

“…We molecularly characterized tumors from non‐small cell lung cancer patients, focusing on long‐term responders to immune checkpoint inhibitors and showed that…”
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199-LB: ATF4 Deletion in Brown Adipose Tissue Impairs Adaptive Thermogenesis but Attenuates Diet-Induced Insulin Resistance by BJORKMAN, SARAH, MARTI, ALEX A., WEATHERFORD, ERIC T., GARCÍA-PEÑA, LUIS M., POTTHOFF, MATTHEW J., ABEL, EVAN D., PEREIRA, RENATA

“…Short-term cold exposure induces the integrated stress response (ISR) and its main effector, the activating transcription factor 4 (ATF4), in brown adipose…”
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OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21 by Pereira, Renata O, Marti, Alex, Olvera, Angela Crystal, Tadinada, Satya Murthy, Bjorkman, Sarah Hartwick, Weatherford, Eric Thomas, Morgan, Donald A, Westphal, Michael, Patel, Pooja H, Kirby, Ana Karina, Hewezi, Rana, Bùi Trân, William, García-Peña, Luis Miguel, Souvenir, Rhonda A, Mittal, Monika, Adams, Christopher M, Rahmouni, Kamal, Potthoff, Matthew J, Abel, E Dale

“…Adrenergic stimulation of brown adipocytes alters mitochondrial dynamics, including the mitochondrial fusion protein optic atrophy 1 (OPA1). However, direct…”
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Chronic pulmonary aspergillosis in a tertiary care centre in Spain: A retrospective, observational study by Aguilar‐Company, Juan, Martín, María Teresa, Goterris‐Bonet, Lidia, Martinez‐Marti, Alex, Sampol, Júlia, Roldán, Elisa, Almirante, Benito, Ruiz‐Camps, Isabel

“…Summary The aim of this study was to describe the characteristics of patients with chronic pulmonary aspergillosis (CPA) in a tertiary care centre in Spain…”
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Dynamic changes in circulating tumor DNA assessed by shallow whole‐genome sequencing associate with clinical efficacy of checkpoint inhibitors in NSCLC by Carbonell, Caterina, Frigola, Joan, Pardo, Nuria, Callejo, Ana, Iranzo, Patricia, Valdivia, Augusto, Priano, Ilaria, Cedrés, Susana, Martinez‐Marti, Alex, Navarro, Alejandro, Lenza, Laura, Soleda, Mireia, Gonzalo‐Ruiz, Javier, Vivancos, Ana, Sansó, Miriam, Carcereny, Enric, Morán, Teresa, Amat, Ramon, Felip, Enriqueta

“…Immune checkpoint inhibitors (ICIs) targeting the PD‐1/PD‐L1 axis are the main therapeutic option for patients with advanced non‐small cell lung cancer (NSCLC)…”
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