Search Results - "Marsters, J. C."

Generation of an LFA-1 Antagonist by the Transfer of the ICAM-1 Immunoregulatory Epitope to a Small Molecule by Gadek, T. R., Burdick, D. J., McDowell, R. S., Stanley, M. S., Marsters, J. C., Paris, K. J., Oare, D. A., Reynolds, M. E., Ladner, C., Zioncheck, K. A., Lee, W. P., Gribling, P., Dennis, M. S., Skelton, N. J., Tumas, D. B., Clark, K. R., Keating, S. M., Beresini, M. H., Tilley, J. W., Presta, L. G., Bodary, S. C.

“…The protein-protein interaction between leukocyte functional antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) is critical to lymphocyte and…”
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Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation in Animal Cells by James, Guy L., Goldstein, Joseph L., Brown, Michael S., Rawson, Thomas E., Somers, Todd C., McDowell, Robert S., Crowley, Craig W., Lucas, Brian K., Levinson, Arthur D., Marsters, James C.

“…Oncogenic Ras proteins transform animal cells to a malignant phenotype only when modified by farnesyl residues attached to cysteines near their carboxyl…”
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Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor by Wong, H., Chen, J.Z., Chou, B., Halladay, J.S., Kenny, J.R., La, H., Marsters, J.C., Plise, E., Rudewicz, P.J., Robarge, K., Shin, Y., Wong, S., Zhang, C., Khojasteh, S.C.

“…GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide) is a potent, selective Hedgehog (Hh) signalling pathway inhibitor being…”
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Anti-NaPi2b antibody–drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study by Banerjee, S., Oza, A.M., Birrer, M.J., Hamilton, E.P., Hasan, J., Leary, A., Moore, K.N., Mackowiak-Matejczyk, B., Pikiel, J., Ray-Coquard, I., Trask, P., Lin, K., Schuth, E., Vaze, A., Choi, Y., Marsters, J.C., Maslyar, D.J., Lemahieu, V., Wang, Y., Humke, E.W., Liu, J.F.

“…Lifastuzumab vedotin (LIFA) is a humanized anti-NaPi2b monoclonal antibody conjugated to a potent antimitotic agent, monomethyl auristatin E, which inhibits…”
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Tetrapeptide Inhibitors of Protein Farnesyltransferase: Amino-Terminal Substitution in Phenylalanine-Containing Tetrapeptides Restores Farnesylation by Brown, Michael S., Goldstein, Joseph L., Paris, Kenneth J., Burnier, John P., James C. Marsters, Jr

“…Protein farnesyltransferase from rat brain transfers farnesyl residues to cysteine residues in tetrapeptides that conform to the sequence CA1A2X, where C is…”
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Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates by SHEA, R. G, MARSTERS, J. C, BISCHOFBERGER, N

“…Triethylammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate (2) was coupled to the 5' terminus of oligodeoxynucleotides via hydrogen phosphonate solid…”
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Use of a Prenylation Inhibitor as a Novel Antiviral Agent by Glenn, J S, Marsters, Jr, J C, Greenberg, H B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Structure-Based Database of Antibody Variable Domain Diversity by Bond, Christopher J., Wiesmann, Christian, Marsters, James C., Sidhu, Sachdev S.

“…The diversity of natural antibodies is limited by the genetic mechanisms that engender diversity and the functional requirements of antigen binding. Using an…”
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Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland by Blaber, Michael, Isackson, Paul J, Marsters, James C, Burnier, John P, Bradshaw, Ralph A

“…The kinetic constants for the hydrolysis of a series of tripeptide p-nitroanilide substrates by mouse epidermal growth factor binding protein (EGF-BP), the…”
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Contributions of CDR3 to VHH Domain Stability and the Design of Monobody Scaffolds for Naive Antibody Libraries by Bond, Christopher J., Marsters, James C., Sidhu, Sachdev S.

“…Camelids produce functional antibodies devoid of light chains. Autonomous heavy chain variable (VHH) domains in these molecules have adapted to the absence of…”
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Synthetic chimeras of mouse growth factor‐associated glandular kallikreins. I. Kinetic properties by Blaber, Michael, Isackson, Paul J., Bradshaw, Ralph A., Burnier, John P., Marsters, James C.

“…A series of six chimeric proteins, composed of fragments corresponding to either one or the other of the growth factor‐associated mouse glandular…”
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Farnesyl transferase inhibitors: the successes and surprises of a new class of potential cancer chemotherapeutics by Buss, Janice E., Marsters, James C.

“…Proteins that transmit abnormal growth signals offer enticing points of intervention for the treatment of cancer. The discovery that isoprenoid attachment is…”
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Benzodiazepine peptidomimetic inhibitors of farnesyltransferase by Marsters, Jr, J C, McDowell, R S, Reynolds, M E, Oare, D A, Somers, T C, Stanley, M S, Rawson, T E, Struble, M E, Burdick, D J, Chan, K S

“…A structural survey of protein Zn2+ binding geometries was instigated based upon the functional requirement of Ras farnesyltransferase for Zn2+. The…”
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Kinetics of iron(III) porphyrin catalyzed epoxidations by Traylor, Teddy G, Marsters, James C, Nakano, Taku, Dunlap, Beth E

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More on general practitioners and orthodontics by Marsters, James C.

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Picosecond geminate recombination of nitrosylmyoglobins by Jongeward, K A, Marsters, J C, Mitchell, M J, Magde, D, Sharma, V S

“…The kinetics of NO geminate recombination to sperm whale and elephant myoglobins has been studied on the picosecond time scale using an amplified…”
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Tuning in to deaf children by Marsters, J C

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VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism by Gerber, Hans-Peter, Malik, Ajay K, Solar, Gregg P, Sherman, Daniel, Liang, Xiao Huan, Meng, Gloria, Hong, Kyu, Marsters, James C, Ferrara, Napoleone

“…Vascular endothelial growth factor (VEGF) is a principal regulator of blood vessel formation and haematopoiesis, but the mechanisms by which VEGF…”
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Selective detection of membrane proteins without antibodies: a mass spectrometric version of the Western blot by Arnott, David, Kishiyama, Adrianne, Luis, Elizabeth A, Ludlum, Sarah G, Marsters, Jr, James C, Stults, John T

“…A method has been developed, called the mass western experiment in analogy to the Western blot, to detect the presence of specific proteins in complex mixtures…”
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CDK2/cyclinA inhibitors: Targeting the cyclinA recruitment site with small molecules derived from peptide leads by Castanedo, Georgette, Clark, Kevin, Wang, Shumei, Tsui, Vickie, Wong, Mengling, Nicholas, John, Wickramasinghe, Dineli, Marsters, James C., Sutherlin, Daniel

“…The syntheses of potent small molecule inhibitors of the CDK2/cyclinA recruitment site are described. Structure–activity trends of nanomolar octapeptides were…”
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